Distribution of Human Papillomavirus Genotypes in Anal Cytological and Histological Specimens from HIV-Infected Men Who Have Sex with Men and Men Who Have Sex with Women

Darwich, Laila; Videla, Sebastián; Cañadas, MariPaz; Piñol, Marta; Cuyàs, Francesc García; Vela, Sandra; Molina‐López, Rafael A.; Coll, J; Sirera, Guillem; Clotet, Bonaventura

doi:10.1097/dcr.0b013e31829c654f

Cited by 49 publications

(36 citation statements)

References 36 publications

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“…The results were very similar to those published by other authors who had observed the percentage of anal dysplasia with low grade cytology (LSIL) at around 40%, 19% ≥AIN2 lesions and the most-frequently identified HPV16 genotype [23].…”

Section: Discussionsupporting

confidence: 91%

Antiretroviral Therapy as a Factor Protective against Anal Dysplasia in HIV-Infected Males Who Have Sex with Males

et al. 2014

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ObjectivesChronic infection with oncogenic HPV genotype is associated with the development of anal dysplasia. Antiretroviral therapy (ART) has been shown to decrease the incidence of cervical carcinoma in women with HIV. We sought to: 1) describe the prevalence and grade of anal dysplasia and HPV infection in our study subjects; 2) analyze the grade of correlation between anal cytology, PCR of high-risk HPV, and histology; 3) identify the factors associated with the appearance of ≥AIN2 lesions.DesignCross-sectional, prospective study.MethodsA cohort of HIV-positive males (n = 140, mean age = 37 years) who have sex with males (MSM) had epidemiological, clinical and analytical data collected. Anal mucosa samples were taken for cytology, HPV PCR genotyping, and anoscopy for histological analysis.ResultsWithin the cohort, 77.1% were being treated with ART, 8.5% anoscopy findings were AIN2, and 11.4% carcinoma in situ; 74.2% had high-risk (HR), 59.7% low-risk (LR) HPV genotypes and 46.8% had both. The combination of cytology with PCR identifying HR-HPV better predicts the histology findings than either of these factors alone. Logistic regression highlighted ART as a protective factor against ≥AIN2 lesions (OR: 0.214; 95%CI: 0.054–0.84). Anal/genital condylomas (OR: 4.26; 95%CI: 1.27–14.3), and HPV68 genotype (OR: 10.6; 95%CI: 1.23–91.47) were identified as risk factors.ConclusionsIn our cohort, ART has a protective effect against dysplastic anal lesions. Anal/genital warts and HPV68 genotype are predictors of ≥AIN2 lesions. Introducing PCR HPV genotype evaluation improves screening success over that of cytology alone.

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Section: Discussionsupporting

confidence: 91%

Antiretroviral Therapy as a Factor Protective against Anal Dysplasia in HIV-Infected Males Who Have Sex with Males

et al. 2014

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“…This was demonstrated by the low number of patients with invalid results from anal cytology (0.5%), as well as the discordant cytological and histological findings (HSIL cytology and absence of histological abnormalities), three (1.4%) (33). Our rate of identification of high-grade histological lesions was similar to that of some other relevant groups (34) and two important studies performed in our country (35,36), the first of which was carried out in one of the largest cities in Spain. The concordance between HSIL cytology and the histological HSIL result has been high, denoting the diagnostic value of this cytological grade (22,37,38).…”

Section: Discussionsupporting

confidence: 56%

“…We used a Carl Zeiss 150FC (Carl Zeiss, Oberkochen, Germany) colposcope for HRA. HR-HPV genotyping was carried out by polymerase chain reaction amplification according to the Cobas 4800 HPV system test (Hoffmann -La Roche Ltd. Rotkreuz, Switzerland), with three TaqMan probes: two specific for the HPV 16 and HPV 18, and another for types 31,33,35,39,45, 51, 52, 56, 58, 59, 66 and 68.…”

Section: Prevalence Study Of Cytological Abnormalities and Hr-hpv Infmentioning

confidence: 99%

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

et al. 2017

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Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain. Rev Esp Enferm Dig 2017;109(4):242-249. DOI: 10.17235/reed.2017109(4):242-249. DOI: 10.17235/reed. .4274/2016 Received: 26-02-201626-02- Accepted: 22-12-2016 ABSTRACT Background and aims:Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain).Method: Prospective cohort analysis of 240 HIV-infected MSM. Cellular anal sample and high risk HPV (HR-HPV)-tests were performed to study cytological changes and HPV genotyping. High resolution anoscopy (HRA) was performed in 209 patients. Results were analyzed with respect to epidemiological, clinical and analytical factors.Results: Of 209 patients selected for HRA, the prevalence of HR-HPV anal infection, cytological and histological alterations was 85.6%, 47.5%, and 39.8%, respectively. Sensitivity and specificity for ≥ ASCUS (atypia of squamous cells of undetermined significance) cytology in relation to histological alterations were 61% and 85%, (OR: 8.7; IC 95%: 4.4-17.2), respectively. Observed concordance between high-grade squamous intraepithelial lesion (HSIL) cytology and HSIL anal intraepithelial neoplasia types 2 and 3 (AIN-2/3) histology was 64% (OR: 11.4; IC 95%: 3.6-36.7). One patient with HSIL cytology presented a prevalent anal squamous carcinoma.Conclusions: HRA was feasible with similar results to relevant groups. There was a high prevalence of anal HR-HPV infection, and cytological and histological alterations.

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“…Previous studies have shown that anal HPV infection are more prevalent among HIV-infected MSM than among HIV-infected MSW (84–85.6% vs 40.8–46%)[29, 30, 33]. HIV-infected MSM also had a higher prevalence of HR-HPV compared with HIV-infected MSW (54–75% vs 18–28%)[31, 32, 34].…”

Section: Discussionmentioning

confidence: 99%

Anal Human Papillomavirus Infection among HIV-Infected Men in Korea

Lee

et al. 2016

PLoS ONE

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BackgroundLittle is known about the epidemiology on human papillomavirus (HPV) infection among HIV-infected men in Korea. The objective of this study was to determine the prevalence, genotype distribution and risk factors associated with anal HPV infection among HIV-infected men in Korea.MethodsA single-center cross-sectional study was conducted with HIV-infected men in Korea. Participants completed a detailed sexual behavior risk factor questionnaire. Anal samples were collected for cytology and HPV genotyping. Factors associated with anal HPV infection were assessed using multivariable logistic regression, stratifying by sexual behaviour.ResultsA total of 201 HIV-infected men were included in the study: 133 were from men who have sex with men (MSM) and 68 from men who have sex with women (MSW). Any anal HPV infection was detected in 82.7% of HIV-infected MSM and in 51.5% of HIV- infected MSW (P < 0.001). High-risk HPV (HR-HPV) prevalence was higher among MSM (47.4%) than MSW (25.0%; P = 0.002). The HR-HPV types identified most frequently were HPV 16 (11%), HPV 18 (9.9%), and HPV 58 (5%) in MSM, and HPV 58(11%) and HPV 16 (8.9%) in MSW. Prevalence of any HPV types in 9-valent vaccine types was higher among MSM than MSW (47.4% vs 22.1%. P = 0.001). Abnormal anal cytology was more commonly detected in MSM than MSW (42.9% vs.19.1%, P < 0.001). In HIV-infected MSM, higher number of lifetime male sex partners was significantly associated with any anal HPV infection, but age was a significant risk factor associated with anal HR-HPV infection.ConclusionAnal HPV infection was highly prevalent in HIV-infected MSM in Korea, and also commonly found in HIV-infected MSW. In HIV-infected MSM, the significant risk factor for being infected with any HPV infection was lifetime number of male sexual partners, and with anal oncogenic HPV infection was age.

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Distribution of Human Papillomavirus Genotypes in Anal Cytological and Histological Specimens from HIV-Infected Men Who Have Sex with Men and Men Who Have Sex with Women

Abstract: Anal cancer screening should be offered to all HIV-infected men, regardless of their sexual orientation.

Cited by 49 publications

References 36 publications

Antiretroviral Therapy as a Factor Protective against Anal Dysplasia in HIV-Infected Males Who Have Sex with Males

Antiretroviral Therapy as a Factor Protective against Anal Dysplasia in HIV-Infected Males Who Have Sex with Males

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

Anal Human Papillomavirus Infection among HIV-Infected Men in Korea

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