Distribution of Human Sapovirus Strain Genotypes over the Last Four Decades in Japan: a Global Perspective

Doan, Yen Hai; Yamashita, Yu; Shinomiya, Hiroto; Motoya, Takumi; Sakon, Naomi; Suzuki, Riéko; Shimizu, Hideaki; Shigemoto, Norifumi; Harada, Seiya; Yahiro, Shunsuke; Tomioka, Kyoko; Sakagami, Akie; Ueki, Yo; Komagome, Rika; Saka, Kyohei; Okamoto-Nakagawa, Reiko; Shirabe, Komei; Mizukoshi, Fuminori; Arita, Yono; Haga, Kei; Katayama, Kazuhiko; Kimura, Hirokazu; Muramatsu, Masamichi; Oka, Takahiro

doi:10.7883/yoken.jjid.2022.704

Cited by 8 publications

(1 citation statement)

References 14 publications

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“…A study in Vietnam (2007Vietnam ( -2008 that included a single hospital detected three genotypes: GI.1, GI.2, and GII.1, while another study in Japan from 2014 to 2017 reported six SaV circulating genotypes: GI.1, GII.1, GIV.1, GI.2, GI.3, and GII.3, of which the proportion of GI.1 (83.3%) was higher than that in most other studies [28,32]. Genotypes GI.1 and GI.2 were the predominant circulating strains in other Asian countries and globally [33,34].…”

Section: Discussionmentioning

confidence: 83%

Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam

Mai,

Ly,

Doan

et al. 2023

Viruses

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Rotavirus (RV), norovirus (NoV), sapovirus (SaV), and human astrovirus (HAstV) are the most common viral causes of gastroenteritis in children worldwide. From 2016 to 2021, we conducted a cross-sectional descriptive study to determine the prevalence of these viruses in hospitalized children under five years old in Nam Dinh and Thua Thien Hue provinces in Vietnam during the pilot introduction of the RV vaccine, Rotavin-M1 (POLYVAC, Hanoi, Vietnam). We randomly selected 2317/6718 (34%) acute diarrheal samples from children <5 years of age enrolled at seven sentinel hospitals from December 2016 to May 2021; this period included one year surveillance pre-vaccination from December 2016 to November 2017. An ELISA kit (Premier Rotaclone®, Meridian Bioscience, Inc., Cincinnati, OH, USA) was used to detect RV, and two multiplex real-time RT-PCR assays were used for the detection of NoV, SaV and HAstV. The prevalence of RV (single infection) was reduced from 41.6% to 22.7% (p < 0.0001) between pre- and post-vaccination periods, while the single NoV infection prevalence more than doubled from 8.8% to 21.8% (p < 0.0001). The SaV and HAstV prevalences slightly increased from 1.9% to 3.4% (p = 0.03) and 2.1% to 3.3% (p = 0.09), respectively, during the same period. Viral co-infections decreased from 7.2% to 6.0% (p = 0.24), mainly due to a reduction in RV infection. Among the genotypeable samples, NoV GII.4, SaV GI.1, and HAstV-1 were the dominant types, representing 57.3%, 32.1%, and 55.0% among the individual viral groups, respectively. As the prevalence of RV decreases following the national RV vaccine introduction in Vietnam, other viral pathogens account for a larger proportion of the remaining diarrhea burden and require continuing close monitoring.

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Section: Discussionmentioning

confidence: 83%

Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam

Mai,

Ly,

Doan

et al. 2023

Viruses

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Epidemiology and molecular evolution of GI.1 sapovirus in the recent era

Hoque,

Akari,

Khamrin

et al. 2024

Journal of Medical Virology

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Sapovirus (SaV) infection is increasing worldwide. Herein, we provided evidence of a significant increase in SaV infection in Japan during 2010–2022, primarily due to the considerable (p = 0.0003) rise of the GI.1 genotype. Furthermore, we found that all major and minor SaV outbreaks in Japan, including the largest SaV outbreak in 2021–2022, were caused by the GI.1 genotype. Therefore, to get insight into the underlying molecular mechanism behind this rising trend of the SaV GI.1 type, we selected 15 SaV GI.1 outbreak strains for complete genome analysis through next‐generation sequencing. Phylogenetically, our strains remained clustered in different branches in lineages I and II among the GI.1 genotype. We showed all amino acid (aa) substitutions in different open reading frames (ORFs) in these strains. Importantly, we have demonstrated that the strains involved in the largest SaV outbreak in Japan in 2021–2022 belonged to lineage II and possessed the third ORF. We have identified some unique aa mutations in these major outbreak strains in the NS1 and NS6‐NS7 regions that are thought to be associated with viral pathogenicity, cell tropism, and epidemiological competence. Thus, in addition to enriching the database of SaV's complete sequences, this study provides insights into its important mutations.

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Strong evolutionary constraints against amino acid changes in the P2 subdomain of sapovirus GI.1 capsid protein VP1

Yokoyama,

Doan,

Motomura

et al. 2024

Biochemical and Biophysical Research Communications

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Distribution of Human Sapovirus Strain Genotypes over the Last Four Decades in Japan: a Global Perspective

Cited by 8 publications

References 14 publications

Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam

Prevalence and Characterization of Gastroenteritis Viruses among Hospitalized Children during a Pilot Rotavirus Vaccine Introduction in Vietnam

Epidemiology and molecular evolution of GI.1 sapovirus in the recent era

Strong evolutionary constraints against amino acid changes in the P2 subdomain of sapovirus GI.1 capsid protein VP1

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