Distribution of intraocular pressure, central corneal thickness and vertical cup‐to‐disc ratio in a healthy Iranian population: the Yazd Eye Study

Pakravan, Mohammad; Javadi, Mohammad Ali; Yazdani, Shahin; Ghahari, Elham; Behroozi, Z; Soleimanizad, Reza; Moghimi, Sasan; Nilforoushan, Naveed; Zarei, Reza; Eslami, Yadollah; Ghassami, Mahmood; Ziaei, Hossein; Katibeh, Marzieh; Tabesh, Hamed; Yaseri, Mehdi

doi:10.1111/aos.13231

Cited by 19 publications

(25 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, as there is no comparison group for the Mongolian patients, their OPT thinner CCT finding is harder to compare [77]. Caucasian, Hispanic, Latino, Chinese, Filipino, Korean, Malay, and Iranian populations have thicker CCT compared to those listed above, as is illustrated in Table 1 [36,40,41,76,[78][79][80][81][82]. Overall, ethnicity should be considered when interpreting CCT, given the variations.…”

Section: Ethnic Groupsmentioning

confidence: 99%

The thick and thin of the central corneal thickness in glaucoma

Belovay

Goldberg

2018

Eye

View full text Add to dashboard Cite

Central corneal thickness (CCT) is an important parameter in the assessment of any potential glaucoma patient. While it affects prognosis in ocular hypertension, its value in patients diagnosed with glaucoma is less certain. There are several biological factors and genetic components that may influence glaucoma progression, which have been associated with thinner CCT. The CCT itself can be affected by several factors including ethnicity, age, sex, glaucoma medications, genetics, and the subtype of glaucoma. Besides, there is variability in the measurement of CCT between difference types of devices. These factors need to be considered in the evaluation of glaucoma patients' CCT and its effect on interpretation of intraocular pressure levels and risk stratification.

show abstract

Section: Ethnic Groupsmentioning

confidence: 99%

The thick and thin of the central corneal thickness in glaucoma

Belovay

Goldberg

2018

Eye

View full text Add to dashboard Cite

show abstract

“…Although local studies have been conducted in different countries to determine the distribution of VCDR, 2 3 4 5 6 8 9 11 12 13 14 15 16 17 18 19 only one study has been performed for this purpose in Iran, 20 and therefore, there is a need for further research to provide more information on the distribution of VCDR. Our team set up a cohort study in people aged 40-64 years in Shahroud in recent years, which has provided researchers with valuable information on ocular indices.…”

Section: Introductionmentioning

confidence: 99%

The Distribution of Vertical Cup-To-Disc Ratio and Its Determinants in the Iranian Adult Population

Hashemi

Pakzad

Khabazkhoob

et al. 2020

Journal of Current Ophthalmology

View full text Add to dashboard Cite

Purpose: To determine the distribution of vertical cup-to-disc ratio (VCDR) and its relationship with ocular biometric indices. Methods: This study was conducted in 4737 individuals aged 45-69 years living in Shahroud who participated in the second phase of Shahroud Eye Cohort Study in 2014. All participants underwent eye examinations including the measurement of visual acuity and refraction, slit-lamp biomicroscopy, retinal examination, and fundoscopy. Normality index was used to describe data distribution, and a multiple beta regression, with adjustment for the effect of cluster sampling, was applied to explore the relationship between VCDR and the study variables. Results: The mean [95% confidence interval (CI)] VCDR was 0.297 (0.293-0.301) in all participants; 0.296 (0.291-0.302) in men and 0.297 (0.292-0.302) in women. The highest mean VCDR was seen in the age group 55-59 years (0.299, 95% CI: 0.292-0.307). The 97.5 th percentile was 0.600. According to multiple beta regression analysis, VCDR had a positive association with the female sex ( P = 0.028), spherical equivalent ( P < 0.001), cigarette smoking ( P = 0.020), and axial length ( P < 0.001), and had a negative association with hypertension ( P = 0.001), best corrected visual acuity ( P < 0.001), hyperlipidemia ( P = 0.029) and anterior chamber depth ( P = 0.001). Conclusions: The mean VCDR and the 97.5 th percentile were lower than most other studies. Although ethnicity and race may play a role in this difference, this difference should be considered in clinical decisions in the current population.

show abstract

“…[22–25] Some studies investigating disc parameters only used vertical CDR for this reason. [26, 27] Average CDR was defined as the mean of vertical and horizontal CDR in this study. Since average CDR includes horizontal CDR which is not variable in terms of other ocular parameters, this could be the reason why our data only showed significance with vertical CDR, and not with average CDR in some analyses.…”

Section: Discussionmentioning

confidence: 99%

The effect of parental factors in children with large cup-to-disc ratios

Shin

2017

PLoS ONE

View full text Add to dashboard Cite

BackgroundTo investigate large cup-to-disc ratios (CDR) in children and to determine the relationship between parental CDR and clinical characteristics associated with glaucoma.MethodsTwo hundred thirty six children aged 6 to 12 years with CDR ≥ 0.6 were enrolled in this study. Subjects were classified into two groups based on parental CDR: disc suspect children with disc suspect (CDR ≥0.6) parents and disc suspect children without disc suspect parents. Ocular variables were compared between the two groups.ResultsOf the 236 disc suspect children, 100 (42.4%) had at least one disc suspect parent. Intraocular pressure (IOP) was higher in disc suspect children with disc suspect parents (16.52±2.66 mmHg) than in disc suspect children without disc suspect parents (14.38±2.30 mmHg, p = 0.023). In the group with disc suspect parents, vertical CDR significantly correlated with IOP (R = -0.325, p = 0.001), average retinal nerve fiber layer (RNFL) thickness (R = -0.319, p = 0.001), rim area (R = -0.740, p = 0.001), and cup volume (R = 0.499, p = 0.001). However, spherical equivalent (R = 0.333, p = 0.001), AL (R = -0.223, p = 0.009), and disc area (R = 0.325, p = 0.001) significantly correlated with vertical CDR in disc suspect children without disc suspect parents, in contrast to those with disc suspect parents. Larger vertical CDR was associated with the presence of disc suspect parents (p = 0.001), larger disc area (p = 0.001), thinner rim area (p = 0.001), larger average CDR (p = 0.001), and larger cup volume (p = 0.021).Conclusions and relevanceFamily history of large CDR was a significant factor associated with large vertical CDR in children. In children with disc suspect parents, there were significant correlations between IOP and average RNFL thickness and vertical CDR.

show abstract

Distribution of intraocular pressure, central corneal thickness and vertical cup‐to‐disc ratio in a healthy Iranian population: the Yazd Eye Study

Abstract: Mean IOP, CCT and VCDR were 14.2 ± 2.5 mmHg, 543 ± 35 μm and 0.32 ± 0.14, respectively, in healthy Iranians that is different from other ethnicities. It seems advisable to pay attention to ethnicity for interpretation of each person's variables.

Cited by 19 publications

References 43 publications

The thick and thin of the central corneal thickness in glaucoma

The thick and thin of the central corneal thickness in glaucoma

The Distribution of Vertical Cup-To-Disc Ratio and Its Determinants in the Iranian Adult Population

The effect of parental factors in children with large cup-to-disc ratios

Contact Info

Product

Resources

About