Distribution of keratin 8‐containing cell clusters in mouse embryonic tongue: Evidence for a prepattern for taste bud development

Mbiene, Joseph‐Pascal; Roberts, John David

doi:10.1002/cne.10551

Cited by 67 publications

(76 citation statements)

References 41 publications

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“…2 E-G). Although the temporal sequence of papilla development has been established in several species, the mechanisms involved in papilla differentiation, patterning, growth and morphogenesis are not elucidated (Bao et al, 1995;Chou et al, 2001;Krimm et al, 2001;Mbiene and Roberts, 2003;Mistretta et al, 2003). It should be noted that the signalling molecules, growth factors, transcription factors, cell surface receptors and extracellular matrix proteins, which have been implicated in the morphogenetic regulation of many other epithelial appendages, are also associated with the initiation of the tongue papillae formation.…”

Section: Pattern Formation and Molecular Studies In Gustatory Papillamentioning

confidence: 99%

Spacing patterns on tongue surface-gustatory papilla.

Jung¹,

Akita²,

Kim³

2004

Int. J. Dev. Biol.

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The dorsal surface of the mammalian tongue is covered with four kinds of papillae, fungiform, circumvallate, foliate and filiform papillae. With the exception of the filiform papillae, these types of papillae contain taste buds and are known as the gustatory papillae. The gustatory papillae are distributed over the tongue surface in a distinct spatial pattern. The circumvallate and foliate papillae are positioned in the central and lateral regions respectively and the fungiform papillae are distributed on the anterior part of the tongue in a stereotyped array. The patterned distribution and developmental processes of the fungiform papillae indicate some similarity between the fungiform papillae and the other epithelial appendages, including the teeth, feathers and hair. This is because 1) prior to the morphological changes, the signaling molecules are expressed in the fungiform papillae forming area with a stereotyped pattern; 2) the morphogenesis of the fungiform papillae showed specific structures in early development, such as epithelial thickening and mesenchymal condensation and 3) the fungiform papillae develop through reciprocal interactions between the epithelium and mesenchymal tissue. These results led us to examine whether or not the early organogenesis of the fungiform papillae is a good model system for understanding both the spacing pattern and the epithelial-mesenchymal interaction during embryogenesis.KEY WORDS: embryonic development, epithelial appendage, fungiform papillae, gustatory papillae Int. J. Dev. Biol. 48: 157-161 (2004)

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Section: Pattern Formation and Molecular Studies In Gustatory Papillamentioning

confidence: 99%

Spacing patterns on tongue surface-gustatory papilla.

Jung¹,

Akita²,

Kim³

2004

Int. J. Dev. Biol.

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“…Similar pattern was demonstrated in the vallate papilla (AhPin et al, 1989;Hirata and Kanaseki, 1989;Wakisaka et al, 1996Wakisaka et al, , 1998Mbiene and Roberts, 2003). However, in contrast to NP, there was drastic shortfall in taste buds in the apical epithelium with few remaining in the adult vallate papilla.…”

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confidence: 66%

“…Eight, advanced stage in adult animals where extensive innervation was traced especially in close relation with taste buds. These patterns are pretty reminiscent of the same events associated with the development of gustatory structures in the vallate papilla (AhPin et al, 1989;Hirata and Kanaseki, 1989;Wakisaka et al, 1996Wakisaka et al, , 1998Chou et al, 2001;Mbiene and Roberts, 2003). The identical coincidences occurred in the two papillae indicate their similarity in the sequential development of nerve fibers in relation with the two distinct subpopulations of taste buds.…”

Section: Spatiotemporal Differentiation Of Gustatory Structures Of Ramentioning

confidence: 80%

“…In addition, similar evidence has been provided from mutant mice lacking neurotrophins (Nosrat et al, 1997;Zhang et al, 1997;Oakley, 1998;Mistretta et al, 1999) and gustatory nerve disruption in mice embryos (MorrisWiman et al, 1999). Recently, this hypothesis has been challenged when some authors managed to have taste buds generated in the absence of nerves in the axolotl (Barlow et al, 1996) and embryonic taste buds preceded the arrival of nerves in the fungiform papillae (Mbiene and Roberts, 2003).…”

mentioning

confidence: 99%

“…The ontogeny of gustatory nerves and its relation with the induction of lingual papillae and their taste buds have interested many researchers (Torrey, 1940;Farbman, 1965;AhPin et al, 1989;Farbman and Mbiene, 1991;Whitehead and Kachele, 1994;Barlow et al, 1996;Wakisaka et al, 1996Wakisaka et al, , 1998Witt and Reuter, 1998;Chou et al, 2001;Mbiene and Roberts, 2003). It has been long believed that the early arrival of nerves to the gustatory epithelium is the fundamental imperative for neural induction of taste buds (Mistretta, 1998;Oakley, 1998).…”

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confidence: 99%

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Immunohistochemical distribution of growth‐associated protein 43 (GAP‐43) in developing rat nasoincisor papilla

2004

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We employed immunohistochemistry of growth-associated protein 43 (GAP-43) to trace the early development of gustatory nerves and ␣-gustducin to demonstrate mature taste buds in the rat nasoincisor papilla (NP). The sequential changes of gustatory structures revealed eight characteristic stages. One, at embryonic day 16 (E16), GAP-43-immunoreactive (IR) nerve fibers were observed in close relation with presumptive taste buds in the lateral apical epithelium on each side of NP; meanwhile, no immunoreactivity could be observed in the papillary epithelium. Two, at E17, fine GAP-43-IR nerve fibers first invaded the apical epithelium of the papilla. Three, at E19, GAP-43-IR nerve fibers were extensive in apical epithelium and colonized in immature taste buds. Four, at E20, GAP-43-IR nerve fibers were first observed in ductal epithelium (lining the medial wall of nasoincisor ducts). Five, at postnatal day 1 (P1), immunoreactive nerve fibers first coincided with immature taste buds in the ductal epithelium. Six, at P3, ␣-gustducin-IR cells identical for mature taste buds were simultaneously demonstrated in both apical and ductal epithelium. Seven, at P14, progressive taste bud proliferation and maturation as well as neural invasion were demonstrated in all regions of the epithelium. Eight, during advanced stage in adult animals, extensive innervation was traced especially in close relation with taste buds. The sequential topographic patterns of NP gustatory structures seem very specific as compared to those in other locations of mammalian gustatory system. The present study reveals that gustatory nerves preceded the development of taste buds. However Key words: innervation; gustatory epithelium; neural inductionMammalian taste buds are distributed throughout the oropharyngeal epithelium most likely within papillary structures such as vallate, fungiform, foliate, and nasoincisor papillae, while they are diffusely scattered among the soft palatal and laryngeal epithelium (Miller, 1977;Miller and Smith, 1984;Belecky and Smith, 1990). Previous publications revealed that the temporal and spatial patterns of taste buds differ according to their locations and their source of innervation (Belecky and Smith, 1990). Briefly, the fungiform and soft palate taste buds that are innervated by the seventh cranial nerve (facial nerve) develop mostly during prenatal life, while for those innervated by the ninth (glossopharyngeal nerve) cranial nerve such as vallate and foliate or the tenth cranial nerve (vagus nerve), laryngeal taste buds appear at later stages of development. In a previous report, we found the taste

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Anatomy of the Tongue and Taste Buds

Witt

Reutter

2015

Handbook of Olfaction and Gustation

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Distribution of keratin 8‐containing cell clusters in mouse embryonic tongue: Evidence for a prepattern for taste bud development

Cited by 67 publications

References 41 publications

Spacing patterns on tongue surface-gustatory papilla.

Spacing patterns on tongue surface-gustatory papilla.

Immunohistochemical distribution of growth‐associated protein 43 (GAP‐43) in developing rat nasoincisor papilla

Anatomy of the Tongue and Taste Buds

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