2008
DOI: 10.1186/1475-2875-7-74
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Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa

Abstract: Background: Knock-down resistance (kdr) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations at amino acid position 1014 of the voltage-gated sodium channel gene, resulting in either a leucinephenylalanine (L1014F), or a leucine-serine (L1014S) substitution. In An. gambiae S-form populations, the former mutation appears to be widespread in west Africa and has been recently reported from Uganda, while the latter, ori… Show more

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Cited by 203 publications
(221 citation statements)
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“…Adults were assigned to members of the An. gambiae cryptic‐species complex on the basis of morphological tests and molecular analyses (Gillies & Coetzee, 1987; Santolamazza et al., 2008; Scott, Brogdon, & Collins, 1993). …”
Section: Methodsmentioning
confidence: 99%
“…Adults were assigned to members of the An. gambiae cryptic‐species complex on the basis of morphological tests and molecular analyses (Gillies & Coetzee, 1987; Santolamazza et al., 2008; Scott, Brogdon, & Collins, 1993). …”
Section: Methodsmentioning
confidence: 99%
“…These four insecticide classes are also widely used for the control of agricultural pests in Africa (Santolamazza et al ., 2008). This can pose additional selection pressure on malaria vectors when insecticide-contaminated ground water permeates mosquito larval habitats (Ranson et al ., 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Currently, synthetic pyrethroids are the most widely used class of insecticides for controlling mosquito populations. Unfortunately, mosquito populations that are resistant to many synthetic pyrethroids have already been reported, and more will undeniably be identified in the coming decades due to the repeated application and overuse of this insecticidal class (Santolamazza et al 2008, Hardstone et al 2009, Ranson et al 2011.…”
mentioning
confidence: 99%