Distribution of Labeled Chloroquine in the Inner Ear

Dencker, Lennart; Lindquist, Nils Gunnar

doi:10.1001/archotol.1975.00780320043010

Cited by 34 publications

(14 citation statements)

References 15 publications

(1 reference statement)

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“…Chronic exposure to certain toxic substances with melanin affinity, for example, ultimately causes adverse effects in the cells. This mechanism seems to be of importance in the development of some chemically induced lesions in the eye, the inner ear, and in the skin, e.g., by phenothiazine derivatives and chloroquine (Lindquist, 1973;Dencker and Lindquist, 1975). The effects are mainly related to high doseflong-term exposure, and a prominent feature of the lesions is that the histologic changes initially are found in the melanin-containing cells, and successively in adjacent tissues, such as receptor cells.…”

Section: Adverse Effectsmentioning

confidence: 99%

Interaction Between Chemicals and Melanin

Larsson

1993

Pigment Cell Research

261

182

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Various drugs and other chemicals, such as organic amines, metals, polycyclic aromatic hydrocarbons, etc., are bound to melanin and retained in pigmented tissues for long periods. The physiological significance of the binding is not evident, but it has been suggested that the melanin protects the pigmented cells and adjacent tissues by adsorbing potentially harmful substances, which then are slowly released in nontoxic concentrations. Long-term exposure, on the other hand, may build up high levels of noxious chemicals, stored on the melanin, which ultimately may cause degeneration in the melanin-containing cells, and secondary lesions in surrounding tissues. In the eye, e.g., and in the inner ear, the pigmented cells are located close to the receptor cells, and melanin binding may be an important factor in the development of some ocular and inner ear lesions. In the brain, neuromelanin is present in nerve cells in the extrapyramidal system, and the melanin affinity of certain neurotoxic agents may be involved in the development of parkinsonism, and possibly tardive dyskinesia. In recent years, various carcinogenic compounds have been found to accumulate selectively in the pigment cells of experimental animals, and there are many indications of a connection between the melanin affinity of these agents and the induction of malignant melanoma.

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Section: Adverse Effectsmentioning

confidence: 99%

Interaction Between Chemicals and Melanin

Larsson

1993

Pigment Cell Research

261

182

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“…The capacity of the inner ear melanin to accumulate drugs was first observed by Lindquist and Ullberg in 1972 [26]. In 1975, Dencker and Linquist [29] related to ototoxicity of chloroquine to the accumulation of the drug on inner ear melanin. Later, it was shown that local anesthetics like lidocaine also accumulate on inner ear melanin [27].…”

Section: Discussionmentioning

confidence: 97%

Labyrinth Anesthesia – A Forgotten but Practical Treatment Option in Ménière’s Disease

Adunka

Moustaklis

Weber

et al. 2003

ORL

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The aim of this study was to determine the efficiency of labyrinth anesthesia – the intratympanic instillation of lidocaine – in the treatment of Ménière’s disease and to recall a forgotten method. Twenty-four patients (15 male, 9 female), aged from 19.7 to 80.6 years (mean: 47.8 years) with the clinical diagnosis of unilateral Ménière’s disease who underwent labyrinth anesthesia in our department were included in this retrospective study. After local anesthesia of the tympanic membrane, a solution of 4% lidocaine and furfuryladenine (Kinetin) was instilled into the tympanic cavity. Patient records, a questionnaire and a physical examination were used to evaluate vertigo control, hearing loss, tinnitus, and quality of life according to the AAO-HNS criteria before and after surgery. Postoperatively, 87.5% of patients reported at least a noticeable decrease of vestibular symptoms, 66.7% of these patients were free of attacks for an average of 26.5 months. Postoperative hearing was the same or even improved in 87.5% of our patients. Tinnitus was not affected in any individual. Based on the findings presented herein, we consider labyrinth anesthesia a practicable and, due to its safety, highly recommendable therapeutic option for patients suffering from Ménière’s disease.

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“…Por esta razão, o desaparecimento de sua ação após a retirada é lento. Um estudo realizado em ratos, demonstrou alta concentração de FC nos tecidos que contêm melanina no ouvido interno, correspondentes à estria vascular, modíolo, plano semilunatum, paredes do saco e do utrículo e canais semicirculares (6) . Grande deposição de FC foi encontrada nessas estruturas até 13 dias após a injeção, e mesmo após um ano da administração.…”

Section: Ação Do Fosfato De Cloroquina (Fc) No Ouvido Internounclassified

“…A lesão primária ototóxica parece ser nos tecidos secretórios e reabsortivos e não nas células receptoras. O acúmulo e a retenção em longo prazo de FC nas células contendo melanócitos no ouvido interno podem explicar a instalação tardia das lesões e a relação com altas doses cumulativas em lesões ototó-xicas (6) . Murkherjee relatou um caso de disfunção cócleo-vestibular grave após uma série de injeções de FC, na qual foi instituída prontamente a terapia com esteróides e vasodilatadores com melhora da audição alcançando um nível socialmente aceitável.…”

Section: Ação Do Fosfato De Cloroquina (Fc) No Ouvido Internounclassified

Antimaláricos e Ototoxicidade

Figueiredo¹,

Atherino²,

Monteiro³

et al. 2004

Rev. Bras. Reumatol.

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Figueiredo et al. 212ARTIGO DE REVISÃO REVIEW ARTICLE RESUMOOs antimaláricos, como o difosfato de cloroquina, têm sido usados amplamente no tratamento não só da malária, mas também de doenças reumatológicas como a síndrome de Sjögren (SS), artrite reumatóide (AR) e lúpus eritematoso sistêmico (LES). Essas drogas são usadas cronicamente e, em conseqüência do acúmulo nos melanócitos, podem causar hiperpigmentação cutânea, retinopatia e lesão no ouvido interno. Como o protocolo do uso de antimaláricos só envolve a avaliação oftalmológica e das enzimas hepáticas, esta revisão discute a necessidade de novos estudos da avaliação periódica da audição desses pacientes.

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Distribution of Labeled Chloroquine in the Inner Ear

Cited by 34 publications

References 15 publications

Interaction Between Chemicals and Melanin

Interaction Between Chemicals and Melanin

Labyrinth Anesthesia – A Forgotten but Practical Treatment Option in Ménière’s Disease

Antimaláricos e Ototoxicidade

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