DISTRIBUTION OF LIPID-SOLUBLE ANTIOXIDANTS IN LIPOPROTEINS FROM HEALTHY SUBJECTS. II. EFFECTS OF IN VIVO SUPPLEMENTATION WITH Α-Tocopherol

Perugini, C.; Bagnati, Marco; Cau, C.; Bordone, Renato; Paffoni, Paola; Re, Roberta; Zoppis, E.; Albano, Emanuele; Bellomo, Giorgio

doi:10.1006/phrs.1999.0553

Cited by 21 publications

(17 citation statements)

References 26 publications

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“…As in other studies we observed a high correlation between serum retinol and -tocopherol levels and serum total cholesterol concentration TChol [15,17,[40][41][42]. The correlation with TChol is well known and explained by the fact that -tocopherol circulates in blood as part of a lipoprotein complex [43,44]. We found an inverse association between energy intake and serum retinol and -tocopherol concentrations.…”

Section: Discussionsupporting

confidence: 85%

HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

Jaworowska¹,

Bazylak²

2008

TOCBMJ

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Antioxidant vitamins have been reported to protect against a variety of human malignances and multiple chronic degenerative diseases therefore it is important to understand factors that influence their blood levels. The present study was conducted to verify association of serum retinol and -tocopherol levels with obesity, and to assess predictors of their serum concentrations in representative sample population of overweight/obese (n = 51) and normal weight (n = 26) apparently healthy adult female subjects recruited from typical urban area in Poland. Anthropometric measurements were taken from all participants who also completed a questionnaire on selected lifestyle factors. The serum concentrations of retinol and -tocopherol were measured by fully validated Chromsystems diagnostic kit employing isocratic RP-HPLC with switched wavelength UV detection. Intake of energy, fat, vitamin A and E and alcohol consumption were estimated by seven daily dietary records. Multivariate linear regression models were fitted in order to estimate the predictors of serum retinol and -tocopherol concentration. There were no statistically significant differences in the average serum levels of retinol and -tocopherol between overweight/obese and normal weight adult female subjects. Serumtocopherol concentrations were positively correlated with serum total cholesterol level (TChol) and body mass index (BMI), but inversely with total energy intake and past dieting behaviour. The TChol and total energy intake were identified as predictors of serum retinol levels. Intakes of fat and vitamin E and A, age, serum triglyceride concentration, smoking, alcohol consumption and physical activity were unrelated to serum levels of retinol or -tocopherol. The main finding of this study is that obesity is not associated with decreased serum retinol and -tocopherol levels. In addition, these results indicated that dietary intake of vitamin A and E are poor predictors for serum retinol or -tocopherol concentrations. Serum levels of both these vitamins are primarily influenced by TChol, obesity, total energy intake and past dieting behaviour.

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Section: Discussionsupporting

confidence: 85%

HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

Jaworowska¹,

Bazylak²

2008

TOCBMJ

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“…Baseline tocopherol plasma content of the James Bay fishermen was in the reference range reported for other white populations [39,40], whereas mean baseline CoQ10-Total was 30% to 50% higher than those reported for healthy subjects of different countries [30,34,[39][40][41][42]. It seems likely that the elevated baseline and seasonal CoQ10 levels in these fishermen were largely due to fish consumption all year round, which is an established source of exogenous CoQ10 [43].…”

Section: Discussionmentioning

confidence: 91%

Seasonal mercury exposure and oxidant-antioxidant status of James Bay sport fishermen

et al. 2008

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“…In humans, relative lipoprotein distribution analysis indicates that tocopherols are mostly transported in LDL and HDL at similar proportions with less than 20% carried in VLDL and other lipoproteins (Perugini et al, 2000a). However, VLDL accounts for one-third of total a-tocopherol levels after vitamin supplementation (Perugini et al, 2000b).…”

Section: Plasma Lipoprotein Transport Of Vitamin Ementioning

confidence: 99%

Absorption, transport, and tissue delivery of vitamin E

Rigotti¹

2007

Molecular Aspects of Medicine

245

169

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DISTRIBUTION OF LIPID-SOLUBLE ANTIOXIDANTS IN LIPOPROTEINS FROM HEALTHY SUBJECTS. II. EFFECTS OF IN VIVO SUPPLEMENTATION WITH Α-Tocopherol

Cited by 21 publications

References 26 publications

HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

HPLC Assessment and Multivariate Predictability of Serum Retinol and α-Tocopherol Concentrations in Adult Female Subjects

Seasonal mercury exposure and oxidant-antioxidant status of James Bay sport fishermen

Absorption, transport, and tissue delivery of vitamin E

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