Distribution of Male Osteoporosis Patients According to Age, Classification, and Fracture

Abstract

IntroductionOsteoporosis (OP) is a systemic skeletal disorder that increases the risk of fractures due to reduced bone mass and microarchitectural deterioration of bone (1, 2). It is primarily known to affect women because of their increased risk of developing OP (due to menopause, low bone mass, and longer lifetime). However, the occurrence of fractures in men with recently increasing life expectancy has demonstrated that OP is an important public health concern for both genders. Although there are insufficient data on male OP in our country, OP was identified in 2 million men in America according to 2001-2002 data (3). In developed countries, OP prevalence is 13% among men older than 50 years, but it increases to about 70% among men aged more than 80 years (4). Despite the lower prevalence of OP among men than among women, the mortality associated with osteoporotic fractures is higher in advanced-aged men (5, 6). On the other hand, the incidence of hip fractures and prevalence of vertebral fractures in elderly men are half of those in women (7,8).Male OP is divided into two groups. Age-related or idiopathic OP is classified as primary OP, while an underlying cause-induced OP is classified as secondary OP (7). Although primary or idiopathic OP is reported very often in the literature, secondary etiological factors are also frequently encountered as a cause of male OP.Recently, the importance of male OP in terms of morbidity and mortality has been recognized, and thus, studies on this issue are increasing. Therefore, we aimed to investigate the frequency of the diagnosis of male OP among patients who attended our outpatient clinic and the relationship between their ages, diagnoses, and OP classifications of male OP patients and the occurrence of osteoporotic fractures. MethodsThe files of male OP patients who attended the OP outpatient clinics of the Department of Physical Medicine and Rehabilitation (PMR), İstanbul University Cerrahpaşa School of Medicine, TurDistribution of Male Osteoporosis Patients According to Age, Classification, and Fracture Objective: For years, osteoporosis has been recognized as a disease affecting women. However, in recent years, it has been found that male osteoporosis is not as rare as it was thought to be, and fractures in men are an important public health problem. Therefore, we aimed to present the distribution of male osteoporosis patients according to their ages and diagnosis. Methods:We retrospectively reviewed the data of male osteoporosis patients who were admitted to physical medicine and rehabilitation clinics within a duration of one year. According to the World Health Organization (WHO) aging criteria, patients were divided into middle-aged (45-59 years), old (60-74 years), elderly (75-89 years), and senile (>90 year) groups. Male osteoporosis was classified as primary and secondary, and the history of fractures was divided as with or without fractures. Patients were analyzed according to these classifications and age groups. Results:Among the osteoporosis patients, 1,14...

Protective Effects of Selected Botanical Agents on Bone

“…Osteoporosis is a metabolic bone disorder resulting from an imbalance of bone remodelling, in which the rate of bone resorption is higher than the rate of bone formation [ 1 , 2 ]. In turn, this gives rise to low bone mass, microarchitectural deterioration, and eventually an increased risk for fragility fractures [ 1 , 2 , 3 ]. Osteoporosis can be classified into primary (Type I and II) and secondary osteoporosis.…”

“…Both sexes may develop primary type II osteoporosis over the age of 70, whereby both trabecular and cortical bones degenerate, thus causing proximal femora, vertebrae, and radii fractures. Women have a two-fold higher risk than men to suffer from primary type II osteoporosis due to their low peak bone mass [ 2 , 4 , 5 , 6 ]. Secondary osteoporosis is due to medications or certain medical conditions, such as hypogonadism, hyperparathyroidism, or leukemia [ 7 ].…”

“…Prolonged use of some medications can lead to bone loss, such as oral or high-dose inhaled corticosteroids, thyroid hormone replacement, and aromatase inhibitors [ 7 , 8 , 9 ]. Osteoporosis is closely associated with increased mortality due to complications of osteoporotic fractures, particularly at the vertebrae and hips [ 2 , 10 , 11 ].…”

“…Therefore, the search for new drugs is ongoing [ 17 , 18 ]. In addition, the prophylactic agents for osteoporosis are limited to calcium and vitamin D. Recent advancement in phytomedicine has stimulated interests to transform herbal plants into treatment for chronic diseases, like osteoporosis [ 2 , 12 , 19 ]. Some vigorously studied herbal plants have demonstrated antiosteoporotic effects in cellular and animal studies [ 13 , 19 , 20 ].…”