Distribution of mast cells in human dermis: development of a mapping technique

Abstract

A new method was developed to define the distribution of mast cells in normal human skin. The population density was determined in a number of zones of different depth in the dermis. Two regions of the same limb were studied systematically. Both were shown to have mast cell populations of similar size and distribution, with a maximum density immediately below the dermo-epidermal junction, gradually falling to a minimum density in the deeper layers of the dermis. Small secondary peaks were less clearly defined at the base of the dermis. These findings should provide baseline data for comparisons with mast cell population size and distribution in different areas of normal skin, or in similar areas in clinical disorders or experimental conditions.

The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions

“…Vasoactive and chemotactic mediators released from activated mast cells in skin are involved in the pathophysiology of urticarias and allergic dermatitis. The cutaneous mast cell is located in the dermis, frequently in small groups around nerves or blood vessels and in greater numbers close to the dermalepidermal junction Cowen et al, 1979). Skin mast cells can be triggered to degranulate by a variety of factors, both exogenous and endogenous.…”

Mast cells in the dog skin: distribution, density, heterogeneity and influence of fixation techniques

“…Mast cells have been shown to be much more abundant in the superficial dermis than in the deeper dermis in the skin of humans (9,10,21,28), chicken and quails (18), and the dog (2, 23). However, it was more abundant in the deeper dermis than in the superficial dermis in rats (11,23).…”

“…Mast cell play roles in type I hypersensitivity reactions (17,20) and in skin diseases like contact dermatitis and fibrosis (25). These type I hypersensitivity reactions have a role in the formation of atopic dermatitis in the dog (9,25).…”

Tavuk Ve Bildircin Deri̇si̇nde Mast Hücreleri̇ni̇n Morfoloji̇k Ve Hi̇stometri̇k İncelenmesi̇

“…'ı (31) ör-dek derisinde mast hücrelerinin az sayıda ve epidermise yakın dermis kısımlarında kan damarlarının çevresinde bulunduğunu bildirmektedirler. İnsan derisi ile ilgili çalışmalarda (2, 8,10,22,24), mast hücrelerinin dermisin yüzey-sel kısımlarında daha yoğun, derin kısımlara inildikçe azalan yoğunluklarda ve özellikle kan damarlan, sinir telleri ile kıl folliküllerinin çev-resinde yerleştiklerinden söz edilmektedir. Ça-lışmaya ait bulgular bu literatür bilgileriyle uyum göstermektedir.…”

“…Deride bulunan mast hücrelerinin sayısal ve bölgesel~ağılımı türler arasında değişiklik gösterir (8). Insan derisinde bulunan mast hüc-releri dermisin yüzlek katmanında daha fazla, derine inildikçe giderek azalan yoğunlukta ve NEV~KURTDEDE-MEctr YÖRÜK çoğunlukla da kan damarlan, sinir telleri ve kıl folliküllerinin çevresinde yerleşirler (2.…”