Distribution of methamphetamine and amphetamine in drug abusers’ head hair

Lee, Sooyeun; Han, Eunyoung; Park, Yonghoon; Choi, Hwakyung; Chung, Heesun

doi:10.1016/j.forsciint.2009.05.004

Cited by 52 publications

(31 citation statements)

References 9 publications

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“…The levels detected appear to be very similar to those detected in the hair of adult users from several studies [13,14]. The mean values are very similar whilst the median value is two times higher for the children than the adult users analysed here.…”

Section: Discussionsupporting

confidence: 84%

“…Tsanaclis et al reported a range of 0.1-128 ng/mg (n = 97 [13]), whilst in another large study by Lee et al [14] a broader range and a higher mean (0.5-608.9 ng/mg, mean 21.0 ng/mg, median 10.1 ng/ mg) was reported. The study by Lee et al [14] used a cut off of 0.5 ng/mg, so would not include any MA levels in the 0.1-0.5 ng/ mg range, thus inflating the mean.…”

Section: Resultsmentioning

confidence: 91%

See 1 more Smart Citation

Quantitative analysis of methamphetamine in hair of children removed from clandestine laboratories – Evidence of passive exposure?

Bassindale

2012

Forensic Science International

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Section: Discussionsupporting

confidence: 84%

Section: Resultsmentioning

confidence: 91%

Quantitative analysis of methamphetamine in hair of children removed from clandestine laboratories – Evidence of passive exposure?

Bassindale

2012

Forensic Science International

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“…In the second study, researchers divided a sample of hair-test results (n = 2355) into "low, medium and high ranges," defined by various percentiles of MA concentrations with corresponding AM values. The high category, representing the upper 25% of the sample, comprised MA and AM concentrations of 24.5−608.9 ng/mg and 1.7−41.4 ng/mg, respectively [31]. From these findings, it appears that our protocol's AM analysis would have corroborated individual cases of MA use at all levels of detection.…”

Section: Methodsmentioning

confidence: 72%

“…Nevertheless, the protocol's AM LOD would have failed to corroborate a majority of MA positives. Further, this protocol's AM LOQ would have been sensitive enough to provide data for the calculation of only a small percentage of AM/MA ratios, which can be a useful diagnostic tool for interpreting original MA dosages, the possibility of sample contamination, and the independent use of AM [30][31][32].…”

Section: Methodsmentioning

confidence: 99%

Validation and application of hair analysis for the detection of methamphetamine in young Thai adults

et al. 2014

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Background:To date, blood and urine analyses have been the major methods of detecting methamphetamine (MA) use in Thailand. Recently, hair analysis has been introduced as an alternative and complementary procedure. Objectives: To validate a simple, rapid, and economical method of analyzing hair for MA and its metabolite, amphetamine (AM). Methods: The analysis employed solid-phase microextraction (SPME) coupled with gas chromatography and mass spectrometry (GC-MS). Simplicity, rapidity, and economy were achieved, in part, by optimizing SPME conditions and by eliminating deuterated reagents and the derivatization step in GC-MS. The validated method was employed to detect and quantify MA in 1,111 hair samples of young Thai research volunteers who reported using MA in the form of so-called "yaba" tablets at least 3 times during the previous 3 months. Results: Validated data from the study indicated that the method's linearity, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ) met international standards for hair analysis of MA. Expressed as ng of MA per mg of hair (ng/mg), the LOQ was 0.5 ng/mg (102.39% accuracy, 5.46% precision). The method was less sensitive for quantification of AM in hair, with a LOQ of 2.5 ng/mg (103.41% accuracy, 6.95% precision). Using 0.5 ng/mg as a cutoff in the analysis of samples provided by admitted MA users, the study yielded an overall detection rate for MA of 35.5%, with a range of 0.51-54.61 ng/mg; the mean MA level was 4.90 ± 6.78 (±SD) ng/mg. Thirty-one percent of the participants reported they had consumed fewer than 10 yaba tablets during the previous 3 months. Of this group, 29% had hair samples that tested positive for MA. Detection rates trended upwards with increased yaba use. No relationship was found between the number of yaba tablets reportedly consumed and the concentration of MA detected in hair. Conclusions: This study validated a rapid, simple, and economical SPME/GC-MS technique for quantification of MA in hair. The method was less sensitive for quantification of AM.

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“…We also divided the baseline drug concentrations values of MA into low, medium and high ranges defined, respectively, as minima to 25th percentile, 25th percentile to 75th percentile, and 75th percentile to maxima, as described by Lee et al [22]. These MA ranges corresponded to 0.2-4.2, >4.2-24.5 and >24.5-608.9 ng/ mg of hair.…”

Section: Hair Analysis: Detection and Quantitation Of Ma And Ap Aftermentioning

confidence: 99%

Duration of detection of methamphetamine in hair after abstinence

Suwannachom

Thananchai

Junkuy

et al. 2015

Forensic Science International

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Distribution of methamphetamine and amphetamine in drug abusers’ head hair

Cited by 52 publications

References 9 publications

Quantitative analysis of methamphetamine in hair of children removed from clandestine laboratories – Evidence of passive exposure?

Quantitative analysis of methamphetamine in hair of children removed from clandestine laboratories – Evidence of passive exposure?

Validation and application of hair analysis for the detection of methamphetamine in young Thai adults

Duration of detection of methamphetamine in hair after abstinence

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