Distribution of Multi-Resistant Bacterial Isolates from Clinical Specimens in a Hospital Environment of Kingdom of Saudi Arabia

Alavudeen, Sirajudeen Shaik; Easwaran, Vigneshwaran; Asiri, Sultana Ali Abdullah; Alahmari, Manal Hamood Awad; Mohammed, Maha Abdullah; Algahtani, Thikra; Khan, Noohu Abdullah

doi:10.5530/jyp.2017.9.69

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…The results of the determination of the antibiotic sensitivity pattern of the bacterial isolates indicate that all the bacterial isolates expressed high resistance to almost all the test antibiotics. The findings of this study and those of earlier studies by Alavudeen et al (2017), Amsalu et al (2017) and Hove et al (2017) are fundamentally consistent; in those studies, all clinical isolates tested showed high resistance to ciprofloxacin, gentamicin, chloramphenicol, Augmentin, ceftriaxone and cefoxitin, among other commonly used antibiotics. The bacterial isolates revealed by the sensitivity test result revealing resistance to the majority of the antibiotics used can correctly be described as superbugsmulti-drug resistant bacteria.…”

Section: Discussionsupporting

confidence: 91%

Antibiotic susceptibility and plasmid profiling of selected multi-drug resistant bacteria (M.D.R.B.) isolated from ear, nose and throat (E.N.T.) samples in two different hospitals in Cross River State

Otu, F. T.,

John, G. E.,

Okpo, E. A.

et al. 2023

MJM

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Section: Discussionsupporting

confidence: 91%

Antibiotic susceptibility and plasmid profiling of selected multi-drug resistant bacteria (M.D.R.B.) isolated from ear, nose and throat (E.N.T.) samples in two different hospitals in Cross River State

Otu, F. T.,

John, G. E.,

Okpo, E. A.

et al. 2023

MJM

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“… – 1/37 – – – – – 1/26 – – 2/82 (0%) [ 48 , 104 ] Shigella spp. – 1/37 – – – – – – – – 1/82 (1.2%) [ 78 ] S. aureus – 16/37 3/8 – 1/7 – – 10/26 – – 30/82 (22.7%) [ 51 , 59 , 60 , 65 , 71 , 72 , 77 , 78 , 81 , 84 , 88 , 96 , 107 , 108 , 116 , 120 , 125 , 128 , 136 – 139 , 142 , 145 , 151 , 153 , 164 , 166 , 171 , 173 ] S. pneumoniae 1/1 3/37 1/8 – 1/7 1/1 – – 1/1 1/3 ...…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial resistance among GLASS pathogens in conflict and non-conflict affected settings in the Middle East: a systematic review

Truppa

Abo‐Shehada

2020

BMC Infect Dis

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Background In spite of the evident general negative effects of armed conflict on countries’ health systems and populations’ health outcomes, little is known about similar impacts of conflicts on the spread of antimicrobial resistances (AMR). This review was to address this evidence gap and describe: Patterns of AMR in the Middle East (ME) and resistance profiles of pathogens included in the Global AMR Surveillance System (GLASS) supported by the World Health Organization; Differences in proportions of AMR isolates between conflict and non-conflict countries. Methods A systematic literature review was conducted following PRISMA guidelines and searching five electronic databases. Subject heading and free text were searched for “antimicrobial resistances” and “Middle East”, to identify observational studies on AMR published from January 2011 to June 2018. Data were extracted from included articles on a predefined set of variables. Percentages of AMR were analysed as median and interquartile ranges. Risk of bias was assessed using the Newcastle-Ottawa Scale. Results A total of 132 articles met the inclusion criteria. Included studies showed heterogeneity in study design, laboratory methods and standards for interpretation of results, and an overall high risk of bias. Main findings were the following: High proportions of carbapenem resistance in Acinetobacter spp. (median 74.2%), and both carbapenem resistance (median 8.1 and 15.4% for E. coli and K. pneumoniae respectively) and ESBL-production (median 32.3 and 27.9% for E. coli and K. pneumoniae respectively) amongst Enterobacteriaceae. S. aureus isolates showed a median methicillin resistance percentage of 45.1%, while vancomycin resistance was almost absent. A median of 50% of the strains of S. pneumoniae showed non-susceptibility to penicillin. Similar trends were observed in conflict and non-conflict affected countries. Conclusions There is a lack of standardization in the methodological approach to AMR research in the Middle East. The proportion of antibiotic resistances among specific GLASS pathogens is high, particularly among Acinetobacter spp.

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“…Antimicrobial resistance is an internationally recognized threat to health. The resistance to antibiotics in bacterial infections limits the availability of effective treatment options, rendering some commonly encountered bacterial infections difficult to treat, including UTIs ( 7 , 8 ). Antibiotic-resistant infections are also twice as likely to be associated with greater morbidity and mortality concurrent to increased healthcare costs ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibiotic Prescribing Practices and Antimicrobial Sensitivity Patterns in Urinary Tract Related Infectious Diseases in Pediatric Patients

et al. 2021

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Complications of urinary tract infections (UTIs) like kidney failure and septicaemia develop once infections spread from the upper urinary tract to other parts of the body by haematogenous dissemination and they pose great health and economic burden to the countries. This retrospective study was conducted among 132 patients with bacterial UTIs in the inpatient department of tertiary care hospital in Abha, Saudi Arabia. During the study period, Escherichia coli (E. coli) and Klebsiella pneumonia (K. pneumonia) along with other 15 different bacteria were isolated. A significant difference (P < 0.05) was observed between the male and female children population in different age groups. We observed fever (84.09%) as a major symptom (P < 0.05), and seizure (9%) was reported as a major concomitant condition among UTI cases. Around 31.82% of E. coli was found to be the most common uropathogens in pediatric cases followed by 25% in K. pneumoniae. E. coli was observed to be more susceptible (92.86%) to amikacin, ceftriaxone, levofloxacin, ertapenem, gentamycin, meropenem, piperacillin-tazobactam, tigecycline, and ceftazidime. However, meropenem, tigecycline, and amikacin were observed to be effective in 100% of cases of K. pneumoniae. Meanwhile, cephalosporins were the most commonly prescribed drug category among different classes of drugs. Almost 99% of pediatric cases, based on their age, were admitted to the ward, and drugs were administered intravenously. We concluded that microbiology laboratory evidence on the causative organisms and choice of treatment together allows tailoring appropriate treatment regimens in conjunction with clinical experiences.

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Distribution of Multi-Resistant Bacterial Isolates from Clinical Specimens in a Hospital Environment of Kingdom of Saudi Arabia

Cited by 6 publications

References 16 publications

Antibiotic susceptibility and plasmid profiling of selected multi-drug resistant bacteria (M.D.R.B.) isolated from ear, nose and throat (E.N.T.) samples in two different hospitals in Cross River State

Antibiotic susceptibility and plasmid profiling of selected multi-drug resistant bacteria (M.D.R.B.) isolated from ear, nose and throat (E.N.T.) samples in two different hospitals in Cross River State

Antimicrobial resistance among GLASS pathogens in conflict and non-conflict affected settings in the Middle East: a systematic review

Evaluation of Antibiotic Prescribing Practices and Antimicrobial Sensitivity Patterns in Urinary Tract Related Infectious Diseases in Pediatric Patients

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