Distribution of naturally occurring quinones

Thomson, R. H.

doi:10.1007/bf01974983

Cited by 61 publications

(44 citation statements)

References 17 publications

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“…In higher plants, anthraquinones are present in oxidized, reduced, glycosided and condensed forms. Furthermore, anthraquinones are used as dyes, pigments, analytical reagents and chemical means for plant protection (Thomson 1987(Thomson , 1996Muzychkina 1998).…”

Section: Discussionmentioning

confidence: 99%

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Promotive effects of phosphorus on crop productivity, enzyme activities, anthraquinone and sennoside content inCassia toraL. – a medicinal herb

Naeem

Masroor

Khan

et al. 2009

Journal of Plant Interactions

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The plants of Cassia tora L. were grown in pots containing soil, supplied with five levels of phosphorus: 0 (Control), 0.1, 0.2, 0.3 and 0.4 g P per kg soil. The fresh and dry weights, number of leaves and leaf-area per plant were recorded. The leaves were analyzed for inorganic elements, such as nitrogen, phosphorus, potassium and calcium. Physiological and biochemical attributes including chlorophyll and carotenoid content, nitrate reductase activity, carbonic anhydrase activity, net photosynthetic rate, stomatal conductance and transpiration rate were determined. Yield attributes including number of pods, number of seeds per pod, 100-seed weight, and seed-yield per plant were recorded. In addition, protein, total anthraquinone glycosides (in seeds) and total sennoside content (in pods) were also estimated. The results showed that phosphorus at the level of 0.3 g per kg soil proved optimum and significantly enhanced most of the attributes studied.

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Section: Discussionmentioning

confidence: 99%

“…The leaves and seeds contain anthraquinone compounds ( Figure 1) that are widely known for their laxative, antiseptic, antifungal, anti-inflammatory, anticancer properties as well as treatment of skin diseases (Thomson 1987(Thomson , 1996Gritsanapan et al 2005). The leaves are administered for the treatment of tuberculosis and ringworms.…”

Section: Introductionmentioning

confidence: 99%

Promotive effects of phosphorus on crop productivity, enzyme activities, anthraquinone and sennoside content inCassia toraL. – a medicinal herb

Naeem

Masroor

Khan

et al. 2009

Journal of Plant Interactions

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“…The connection between the [NAD(P)H]/[NAD (P) ϩ ] ratio and ␤-oxidation is assumed to be due to the cofactor requirement of NAD ϩ for 3-hydroxyacyl-CoA dehydrogenases, which catalyze the third step in ␤-oxidation (10). We also hypothesized the reduced enzyme is oxidized by quinones because they are prevalent redox agents in nature (11,12). To investigate this hypothesis, we experimentally tested NADH, NADPH, and various quinones for catalytic activity.…”

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confidence: 99%

Functional Annotation of a Presumed Nitronate Monoxygenase Reveals a New Class of NADH:Quinone Reductases

Ball¹,

Salvi²,

Gadda³

2016

Journal of Biological Chemistry

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The protein PA1024 from Pseudomonas aeruginosa PAO1 is currently classified as 2-nitropropane dioxygenase, the previous name for nitronate monooxygenase in the GenBank TM and PDB databases, but the enzyme was not kinetically characterized. In this study, PA1024 was purified to high levels, and the enzymatic activity was investigated by spectroscopic and polarographic techniques. Purified PA1024 did not exhibit nitronate monooxygenase activity; however, it displayed NADH:quinone reductase and a small NADH:oxidase activity. The enzyme preferred NADH to NADPH as a reducing substrate. PA1024 could reduce a broad spectrum of quinone substrates via a Ping Pong Bi Bi steady-state kinetic mechanism, generating the corresponding hydroquinones. The reductive half-reaction with NADH showed a k red value of 24 s ؊1 and an apparent K d value estimated in the low micromolar range. The enzyme was not able to reduce the azo dye methyl red, routinely used in the kinetic characterization of azoreductases. Finally, we revisited and modified the existing six conserved motifs of PA1024, which define a new class of NADH:quinone reductases and are present in more than 490 hypothetical proteins in the GenBank TM , the vast majority of which are currently misannotated as nitronate monooxygenase.

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“…Hundreds of natural compounds of plant and animal origin have properties of angiogenic inhibitors [6-. One of them is aloe-emodin [1,8-dihydroxy-3-hydroxymethylanthraquinone], bioactive hydroxyanthraquinone Aloe barbadensis Miller (Aloe vera), Rheum officinale, as well as in leaves and roots of other plants [9], showing in vitro and antitumor activity and anti-angiogenic properties [10,11].…”

Section: Introductionmentioning

confidence: 99%

Aloe-emodin triggers ROS and Ca 2+ production and decreases the levels of mitochondrial membrane potential of human brain capillary endothelial cells

Dimova¹,

Danova²,

Nikolova³

et al. 2017

ijpm

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A b s t r a c tThe aim of this hydroxyanthraquinone aloe hCMEC/D3 and to assess the cellular response in the early stage of treatment in order to extend the k capillary endothelial cells hCMEC/D3 were treated with a μM) for a period of 24 hours. The cell viability was determined by MTS assay. The cellul adenosine triphosphate (ATP) levels were evaluated by CellTiter intracellular reactive oxygen species (ROS) were determined by 2',7' H2DCFDA) fluorescence assay. The mitochondrial membrane potential (M using tetramethylrhodamine methyl ester (TMRM) staining, while Fluo the intracellular free Ca using the Arrays Twenty µM, decreased the cell viability as well as the intracellular ATP levels in a dose manner. Increased ROS production and disruption of the have a increased intracellular calcium levels. Our results collectively indicate that AE inhibits proliferation of human brain micro cells via a mechanism involving ROS mitochondrial damage.

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Distribution of naturally occurring quinones

Cited by 61 publications

References 17 publications

Promotive effects of phosphorus on crop productivity, enzyme activities, anthraquinone and sennoside content inCassia toraL. – a medicinal herb

Promotive effects of phosphorus on crop productivity, enzyme activities, anthraquinone and sennoside content inCassia toraL. – a medicinal herb

Functional Annotation of a Presumed Nitronate Monoxygenase Reveals a New Class of NADH:Quinone Reductases

Aloe-emodin triggers ROS and Ca 2+ production and decreases the levels of mitochondrial membrane potential of human brain capillary endothelial cells

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