Distribution of neuropeptide Y (NPY) in the cerebral cortex of the lizards Psammodromus algirus and Podarcis hispanica: Co‐localization of NPY, somatostatin, and GABA

Dávila, JoséCarlos; Calle, Adélaïda de la; Gutiérrez, Antonia; Megı́as, Manuel; Andreu, Manuel J.; Guirado, Salvador

doi:10.1002/cne.903080307

Cited by 42 publications

(31 citation statements)

References 45 publications

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“…Most local interneurons are GABA-immunoreactive (Lopez-Garcia et al 1988 a, Schwerdtfeger and and display either parvalbumin (Fig. 1E), calbindin, or calretinin immunoreactivities (Martinez-Guijarro et al 1991a, Martinez-Guijarro andFreund 1992) as well as a wide spectrum of neuropeptide immunoreactivities (Davila et al 1991) or even NADPH diaphorase/ NOS synthetase (Davila et al 1995).…”

Section: The Cerebral Cortex Of Reptilesmentioning

confidence: 99%

The lizard cerebral cortex as a model to study neuronal regeneration

López‐García

Molowny

Nácher

et al. 2002

An. Acad. Bras. Ciênc.

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The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zincenriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events.

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Section: The Cerebral Cortex Of Reptilesmentioning

confidence: 99%

The lizard cerebral cortex as a model to study neuronal regeneration

López‐García

Molowny

Nácher

et al. 2002

An. Acad. Bras. Ciênc.

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“…GABAergic cortical neurons in turtles also contain one or more neuropeptides (Jones and Hendry, 1986;Davila et al, 1991). For example, the SS+ and NPY + cortical neurons in turtles are likely to be a specific subpopulation of the GABAergic neurons.…”

Section: Cellular Anatomy and Neurochemistry Of Turtle Telencephalic mentioning

confidence: 99%

“…For example, SS+, NPY +, GABA + and LANT6 + neurons have all been found in cortex in lizards (Perez-Clause11 and Fredens, 1988;Davila et al, 1991;Reiner, 1991;Martinez-Guijarro and Freund, 1992). In contrast, neither CCK8+ nor choline@ nonpyramidal neurons of radial morphology have been found in lizard cortex (Perez-Clause11 and Fredens, 1988;Reiner, 1991Reiner, , 1992.…”

Section: Cellular Anatomy and Neurochemistry Of Turtle Telencephalic mentioning

confidence: 99%

Neurotransmitter organization and connections of turtle cortex: implications for the evolution of mammalian isocortex

Reiner

1993

Comparative Biochemistry and Physiology Part A: Physiology

117

116

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Abstract-Telencephalic cortex in turtles is a simple three layered-structure. The dorsal most part of this structure is thought to resemble the reptilian forerunner of at least parts of mammalian isocortex. This dorsal part of turtle cortex contains several functionally distinct regions that show similarity in their connections and function to specific areas in mammalian isocortex. The types of neurons found in turtle dorsal cortex (as defined by their morphology and neurotransmitter content) also show great similarity to those observed in mammals, with the major exception that turtle cortex appears to lack the types of neurons found in granular and supragranular layers of mammalian isocortex. Similar results have also been observed in other living reptiles. Thus, one major step in the evolution of reptilian cortex into mammalian cortex must have been the addition of the types of neurons found in the granular and supragranular layers of mammalian isocortex. These observations for turtles also suggest that turtle cortex in particular and reptilian telencephalic cortex in general must differ functionally from mammalian isocortex with respect to those features associated with the laminar and columnar organization of isocortex. These issues are discussed in more detail below and in Reiner (1991).

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“…For example, some chemically defined neuronal types in mammalian hippocampus are also found in reptilian cortex [Dávila et al, 1988[Dávila et al, , 1991Martínez-Guijarro et al, 1991]. In addition, colocalization of GABA with neuropeptides (somatostatin or NPY) or the calcium-binding protein parvalbumin or with NADPH diaphorase activity indicates that a subclass of the GABAergic hippocampal interneurons in reptiles is very similar to one in mammals [Dávila et al, 1991[Dávila et al, , 1993[Dávila et al, , 1995Martínez-Guijarro et al, 1993]. Some of these neuronal types are also involved in similar synaptic circuits within the hippocampus of reptiles and mammals [Dávila et al, 1993].…”

Section: Introductionmentioning

confidence: 96%

Cholecystokinin Innervation of the Cerebral Cortex in a Reptile, the Lizard Psammodromus algirus

Guirado¹,

Real²,

Padial³

et al. 1998

Brain Behav Evol

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We used light and electron microscopic and immunohistochemical methods to map the distribution of cholecystokinin (CCK) in the cerebral cortex of a lizard, Psammodromus algirus. At light microscopy, the CCK immunoreactivity was limited to fibers and terminals densely innervating all cortical regions except for the lateral (pyriform) cortex which was very slightly immunostained. The CCK-positive terminals were almost restricted to the cell layers in every cortical region where they surrounded immunonegative cell bodies and proximal dendrites of neurons within the layer. No CCK-containing neurons were observed within the cerebral cortex. At the electron microscopic level, most positive structures were presynaptic boutons contacting cell bodies and proximal dendrites. All contacts appeared to form symmetric junctions. both the distribution and type of synaptic contacts of CCK fibers in the cerebral cortex of Psammodromus are very similar to the corresponding features in the hippocampus of mammals, although in this lizard the CCK cortical innervation, unlike that in mammals, is probably of extrinsic origin. Double HRP-retrograde labeling and CCK immunohistochemistry show that part of the CCK in the cerebral cortex of Psammodromus arises from the hypothalamic supramammillary nuclei.

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Distribution of neuropeptide Y (NPY) in the cerebral cortex of the lizards Psammodromus algirus and Podarcis hispanica: Co‐localization of NPY, somatostatin, and GABA

Cited by 42 publications

References 45 publications

The lizard cerebral cortex as a model to study neuronal regeneration

The lizard cerebral cortex as a model to study neuronal regeneration

Neurotransmitter organization and connections of turtle cortex: implications for the evolution of mammalian isocortex

Cholecystokinin Innervation of the Cerebral Cortex in a Reptile, the Lizard <i>Psammodromus algirus</i>

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