1995
DOI: 10.1111/j.1600-0714.1995.tb01148.x
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Distribution of p21ras during primary palate formation of non‐cleft and cleft strains of mice

Abstract: Cleft lip, with or without cleft palate, is one of the most common defects in craniofacial formation. The primary palatogenesis of mice is similar to that of humans and spontaneous cleft lip is associated with genotype in both mice and humans. To investigate the temporal and spatial expression of ras genes in cleft (A/WySn) and non-cleft strains of mice (BALB/cBy), a broad spectrum ras antibody was used. Positive staining was found in ectodermal, mesenchymal, and neuroepithelial cells of facial prominences bef… Show more

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Cited by 4 publications
(1 citation statement)
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“…Tgfb3 was expressed normally in the epithelial seam and mesenchyme of the facial prominences of normal embryos, but was not detected in incipient cleft lip littermates in CL/Fr (Muraoka et al, 2005). The ras protein was detected in mesenchyme and ectoderm of normal control strain and A/WySn strain facial prominences before the fusion stage, was deficient in the A/WySn strain after the fusion stage, and was most deficient in an A/WySn incipient CL embryo (Wang et al, 1995a). Only one study did not report a dichotomy of gene expression: the Erbb4 protein was reported to be deficient in A/WySn embryos after the fusion stage (Wang et al, 1998).…”
Section: Multifactorial Models: (1) the “A” Strains And Their Relativesmentioning
confidence: 99%
“…Tgfb3 was expressed normally in the epithelial seam and mesenchyme of the facial prominences of normal embryos, but was not detected in incipient cleft lip littermates in CL/Fr (Muraoka et al, 2005). The ras protein was detected in mesenchyme and ectoderm of normal control strain and A/WySn strain facial prominences before the fusion stage, was deficient in the A/WySn strain after the fusion stage, and was most deficient in an A/WySn incipient CL embryo (Wang et al, 1995a). Only one study did not report a dichotomy of gene expression: the Erbb4 protein was reported to be deficient in A/WySn embryos after the fusion stage (Wang et al, 1998).…”
Section: Multifactorial Models: (1) the “A” Strains And Their Relativesmentioning
confidence: 99%