Distribution of persistent organochlorine contaminants in infertile patients from Tanzania and Germany

Weiß, Jürgen; Bauer, O.; Blüthgen, A.; Ludwig, A.; Vollersen, E.; Kaisi, M.; Al‐Hasani, S.; Diedrich, K.; Ludwig, Michael

doi:10.1007/s10815-006-9069-6

Cited by 52 publications

(39 citation statements)

References 32 publications

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“…The study by Kalantzi et al (2009) (Erdmann et al, 1999). Levels of PCB congeners found in the current study are comparable to those measured in the general population in other non-industrialised developing countries such as Tanzania and India, but lower than those recently reported from Guinea-Bissau and from industrialised countries in the North (Anda et al, 2008;Linderholm et al, 2010;Todaka et al, 2010;Weiss et al, 2006). Interestingly, PCB levels in Brazilian delivering women were higher than those recently reported in the plasma of delivering women in South Africa and Vietnam Röllin et al, 2009).…”

Section: Discussionsupporting

confidence: 66%

Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of São Paulo State, Brazil

Rudge

Sandanger

Röllin

et al. 2012

Environment International

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2012Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of Sao Paulo State, Brazil ENVIRONMENT INTERNATIONAL, OXFORD, v. 40, Persistent organic pollutants (POPs) present in the living environment are thought to have detrimental health effects on the population, with pregnant women and the developing foetus being at highest risk. We report on the levels of selected POPs in maternal blood of 155 delivering women residing in seven regions within the São Paulo State, Brazil. The following selected POPs were measured in the maternal whole blood: 12 polychlorinated biphenyls (PCBs) congeners (IUPAC Nos. 99, 101, 118, 138, 153, 156, 163, 170, 180, 183, 187, 194); dichlordiphenyltrichloroethane p,p′-DDT, diphenyldichloroethylene p,p′-DDE and other pesticides such as hexachlorocyclohexanes (α-HCH, β-HCH, γ-HCH), hexachlorobenzene (HCB), chlordane derivatives cis-chlordane, transchlordane, oxy-chlordane, cis-nonachlor and trans-nonachlor. Statistical comparisons between regions were performed only on compounds having concentrations above LOD in 70% of the samples. PCB118 congener was found to be highest in the industrial site (mean 4.97 ng/g lipids); PCB138 congener concentration was highest in the Urban 3 site (mean 4.27 ng/g lipids) and congener PCB153 was highest in the industrial and Urban 3 sites with mean concentration of 7.2 ng/g lipids and 5.89 ng/g lipids respectively. Large differences in levels of p,p′-DDE between regions were observed with the Urban 3 and industrial sites having the highest concentrations of 645 ng/g lipids and 417 ng/g lipids, respectively; β-HCH was found to be highest in the Rural 1 site; the γ-HCH in Rural 1 and industrial; the HCB in the Rural 1 and industrial sites and oxy-chlordane and t-NC in the Rural 2 sites. An association between levels of some contaminants and maternal age and parity was also found.

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Section: Discussionsupporting

confidence: 66%

Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of São Paulo State, Brazil

Rudge

Sandanger

Röllin

et al. 2012

Environment International

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“…Magnusdottir et al (2005) concluded that poor semen quality is associated with sedentary work and obesity but not with plasma levels of fourteen organochlorine pesticides including DDT and metabolites. Weiss et al (2006) evaluating exposure, in Germany and in Tanzania, to a mixture of PCBs and pesticides, including DDT, found these pesticides had no impact on sperm quality. However high serum concentrations of DDT-DDE were associated with lower pregnancy rates in Germany.…”

Section: Studies With Little or No Evidence Of An Associationmentioning

confidence: 99%

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Sifakis¹,

Mparmpas²,

Tsatsakis³

2011

Pesticides - Formulations, Effects, Fate

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“…In a study conducted on infertile couples in Germany and Tanzania organochlorine pesticides and PCBs were measured in serum, follicular fluid, or seminal plasma. For infertile men the semen parameters concentration, motility and morphology showed no correlation with serum PCB and PCB was found to have no impact on semen parameters (Weiss et al 2006). Rozati et al (2002) studied the determination of various PCB compounds in semen samples obtained from infertile and fertile individuals.…”

Section: Resultsmentioning

confidence: 99%

Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men

Çok

Durmaz

et al. 2009

Environ Monit Assess

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During the recent two decades, a remarkable drop in fertility rates has been noticed almost all over the world. A series of studies have showed that environmental factors had the primary role causing the observed adverse trends in the male reproductive health problems. Especially chlorinated hydrocarbons, for instance polychlorinated biphenyls (PCB) and pesticides, could mimic or antagonize the effects of steroid hormones, like estrogens and androgens and possibly interfering with male reproductive capacity. Organochlorine pesticides (OCPs) (i.e. p.p'-DDT, endosulfan...) and PCBs are widespread used chemicals in agriculture and industry for different purposes all over the world. Although direct evidence is lacking, theoretical considerations and epidemiological evidence implicate these compounds as potential hazards to human and wildlife reproductive health. For this purpose, in this study adipose tissue samples have provided from healthy males which were diagnosed as infertile men living in Ankara, Turkey at least for 5 years. Residual levels of OCPs (alpha-BHC, beta-BHC, gamma-BHC, HCB, Endosulfan I, II, p,p'-DDE, and p,p'-DDT) and seven major persistent PCB congeners (PCB 28, 52, 101, 118, 138, 153, and 180) were measured in 25 infertile men and 21 healthy men's adipose tissue samples by GC-ECD. Levels of OCPs and PCBs in adipose tissue of infertile men compared with those provided from controls. When the concentrations of each of the OCP were compared between the fertile and infertile groups, no statistical significance was obtained. Concentrations of each of the PCB congeners were compared between the fertile and infertile groups, no statistical significance was obtained (p > 0.05), except for 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) (p = 0.032) and 2,2',3,4,4',5,5'-heptachlorobiphenyl (PCB 180) (p = 0.017).

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Distribution of persistent organochlorine contaminants in infertile patients from Tanzania and Germany

Abstract: The distribution of toxins between agricultural and industrial countries is different. Seminal plasma seems to be inert against chemicals. In patients with high serum concentrations of DDT and DDE pregnancy rates were impaired.

Cited by 52 publications

References 32 publications

Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of São Paulo State, Brazil

Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of São Paulo State, Brazil

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men

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