Distribution of Protease Inhibitors in Lipid Emulsions: Gabexate Mesilate and Camostat Mesilate

Yin, Jiahui; Noda, Yoichi; Hazemoto, Norio; Yotsuyanagi, Toshihisa

doi:10.1248/cpb.53.893

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…While the octanol/water partition coefficient

is estimated to be 0.252 and consistent with Pengfei Xu et al (0.24) [48] . The Camostat estimated

was found to be 497.05 K (SIRM) with an ARD of 2.85 with that of experimental data reported by J. Yin et al [49] . While the Chloroquine estimated

was found to be 385.54 K against the reported value of 363.15 K by M. Staderini et al [50] .…”

Section: Resultssupporting

confidence: 84%

Thermodynamic properties of active pharmaceutical ingredients that are of interest in COVID-19

Nagar

Ingle

Munagala

et al. 2022

Chemical Data Collections

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The pure component properties are estimated for active pharmaceutical ingredients that are related or proposed for the treatment of severe acute respiratory syndrome-CoronaVirus-2. These include Baricitinib, Camostat, Chloroquine, Dexamethasone, Hydroxychloroquine, Fingolimod, Favipiravir, Thalidomide, and Umifenovir. The estimations are based on group contribution + (GC) models that contain combined group contribution and atom connectivity index with uncertainties in the estimated property values. The thermodynamic properties that are reported include boiling point, critical temperature, critical pressure, critical volume, melting point, standard Gibb's energy of formation, standard enthalpy of formation, enthalpy of fusion, enthalpy of vaporization at 298 K, enthalpy of vaporization at boiling point, entropy of vaporization at boiling point, flash point, Hildebrand solubility parameter, octanol/water partition coefficient, acentric factor, and liquid molar volume at 298 K. The reported properties are not available in the literature and thereby is an incremental development for reliable process engineering.

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“…While the octanol/water partition coefficient

is estimated to be 0.252 and consistent with Pengfei Xu et al (0.24) [48] . The Camostat estimated

was found to be 497.05 K (SIRM) with an ARD of 2.85 with that of experimental data reported by J. Yin et al [49] . While the Chloroquine estimated

was found to be 385.54 K against the reported value of 363.15 K by M. Staderini et al [50] .…”

Section: Resultssupporting

confidence: 84%

Thermodynamic properties of active pharmaceutical ingredients that are of interest in COVID-19

Nagar

Ingle

Munagala

et al. 2022

Chemical Data Collections

View full text Add to dashboard Cite

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“…It is postulated that the drugs solubility in these excipients is mostly attributed to dispersion and other vdW forces that are known to exist between hydrophobic drugs and hydrophobic excipients (72,73).…”

Section: Experimental Solubilitymentioning

confidence: 99%

Predicting the Solubility of the Anti-Cancer Agent Docetaxel in Small Molecule Excipients using Computational Methods

et al. 2007

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Determination of 4'-Carbomethoxyphenyl 4-Guanidinobenzoate Mesylate by HPLC and Identification of its Related Substances by LC-MS-MS

Yin

Hang

Zhang

2009

Journal of Chromatographic Science

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4'-Carbomethoxyphenyl 4-guanidinobenzoate mesylate (4'-CMGB) is a sperm acrosin inhibitor. A validated reversed- phase isocratic high-performance liquid chromatographic (HPLC) method for its assay and related substances detection is described. The chromatographic system consists of a C(8) Shimpack column (150 mm x 4.6 mm, 5 microm) with a mobile phase composition of methanol-0.2% ammonium acetate-triethylamine-glacial acetic acid (470:524:1:5, v/v/v/v) and UV detection at 266 nm. The method shows good chromatographic separation for 4'-CMGB and its related substances. The method is found to be linear in the range of 2.0-100 microg/mL, precise, and sensitive (limit of detection of 15 ng/mL). The major related substances are resolved and identified by HPLC and LC-tandem mass spectrometry as p-guanidino benzoic acid, methyl p-guanidino benzoate, and methyl p-hydroxybenzoate.

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Distribution of Protease Inhibitors in Lipid Emulsions: Gabexate Mesilate and Camostat Mesilate

Cited by 5 publications

References 15 publications

Thermodynamic properties of active pharmaceutical ingredients that are of interest in COVID-19

Thermodynamic properties of active pharmaceutical ingredients that are of interest in COVID-19

Predicting the Solubility of the Anti-Cancer Agent Docetaxel in Small Molecule Excipients using Computational Methods

Determination of 4'-Carbomethoxyphenyl 4-Guanidinobenzoate Mesylate by HPLC and Identification of its Related Substances by LC-MS-MS

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