Distribution of pulmonary responsiveness to aerosol histamine in dogs

Snapper, James R.; Drazen, J. M.; Loring, Stephen H.; Schneider, Wolfgang Ludwig; Ingram, R. H.

doi:10.1152/jappl.1978.44.5.738

Cited by 49 publications

(12 citation statements)

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“…1). This demonstrated the expected action of atro pine and has been shown by other workers [8,15], The two given doses of nebulized verapamil inhalation (10 and 100 mg) also appeared to cause a reduction in the maxi mal histamine response when compared to that due to histamine alone (i.e. groups C and D compared to A).…”

Section: Discussionsupporting

confidence: 84%

Interaction of Verapamil Hydrochloride and Atropine Sulphate on Histamine-Induced Bronchoconstriction

Krivoy¹,

Brandt²,

Bunn³

1985

Respiration

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Submaximal histamine dose-response curves were obtained on 34 dogs divided into six groups. These groups were: A (n=6) untreated; B (n=6) after atropine (1 mg/kg); C (n=5) after verapamil inhalation (10 mg total dose); D (n=5) after verapamil inhalation (100 mg total dose); E and F (n=6) as for C and D but pre-treated with atropine (1 mg/kg). Total lung resistance (Rl) was measured in each case at increasing delivered concentrations of inhaled histamine and expressed as a ratio of baseline valve. For each group a composite mean curve was obtained and the maximal recorded responses (mean maximal resistance ratios) for the various groups were compared. It appears that the combination of verapamil inhalation (low dose) and atropine reduced the anticholinergic effect of atropine causing marked bronchoconstriction. This unexpected result depends on the verapamil dose since it was not present at the higher dose (group F).

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Section: Discussionsupporting

confidence: 84%

Interaction of Verapamil Hydrochloride and Atropine Sulphate on Histamine-Induced Bronchoconstriction

Krivoy¹,

Brandt²,

Bunn³

1985

Respiration

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“…This variability may reflect interindividual differences in airway receptor number or sensitivity (Abraham et al, 1980;Ahmed et al, 1980). Susceptibility to O 3 -induced alterations in airway responsiveness has also been shown to be variable within any particular exposure group (Douglas et al, 1977;Snapper et al, 1978;Habib et al, 1979;Abraham et al, 1980).…”

Section: Discussionmentioning

confidence: 99%

Ozone Differentially Modulates Airway Responsiveness in Atopic Versus Nonatopic Guinea Pigs

Schlesinger

Cohen

Gordon

et al. 2002

Inhalation Toxicology

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While acute exposures to ozone (O(3)) can alter airway responsiveness, effects from long-term exposures at low concentrations are less clear. This study assessed whether such exposures could induce nonspecific hyperresponsiveness in nonatopic (nonsensitized) guinea pigs and/or could exacerbate the pre-existing hyperresponsive state in atopic (sensitized) animals, and whether gender was a factor modulating any effect of O(3). Responsiveness was measured during and following exposures to 0.1 and 0.3 ppm O(3) for 4 h/day, 4 days/wk for 24 wk in male and female nonsensitized animals, those sensitized to allergen (ovalbumin) prior to initiation of O(3) exposures, and those sensitized concurrently with exposures. Ozone did not produce hyperresponsiveness in nonsensitized animals, but did exacerbate hyperresponsiveness to both specific and nonspecific bronchoprovocation challenges in sensitized animals, an effect that persisted through at least 4 wk after exposures ended. Gender was not a factor modulating response to O(3). Induced effects on responsiveness were not associated with numbers of eosinophils in the lungs nor with any chronic pulmonary inflammatory response, but were correlated with antigen-specific antibodies in blood. This study supports a role for chronic O(3) exposure in the exacerbation of airways dysfunction in a certain segment of the general population, namely, those demonstrating atopy.

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“…An average of 16 ai&ays were assessed per lamb (range [12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Two of the four CS lambs had DISCUSSION peribronchial mononuclear infiltrate affecting approximately…”

Section: Resultsmentioning

confidence: 99%

Effect of Passive Smoking on the Lung of Young Lambs

1986

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ABSTRACT. The effect of passive smoking on lung histology, lung mechanics, and airway responsiveness (AR) was studied in 2-month-old lambs. Two groups of lambs were studied; 17 were exposed to cigarette smoke (CS) and 13 served as age-and sex-matched controls. Starting at 1 month of age, CS lambs had 25 daily exposures to the smoke generated from eight cigarettes. A smoking machine was constructed for the study using a Bird Ventilator. Two days prior to lung function testing, lambs were anesthetized and a Silastic balloon was placed in the pleural space for later measurement of pleural pressure. At the beginning of each study, lambs were intubated with a nasotracheal tube over a flexible fiberoptic bronchoscope. Lung mechanics (dynamic compliance, resistance of the lung, functional residual capacity) and AR were measured using a whole body plethsymograph. AR to inhaled histamine, carbachol, and citric acid was measured in each lamb on 3 separate days by giving five breaths of increasing concentrations of the aerosol in a noncumulative fashion. AR was measured both within 24 h of the final exposure to CS and at 3-7 days after CS. After the final AR was measured, lambs were anesthetized and an open lung biopsy performed. Control lambs had the same studies as CS lambs performed at an equivalent age. After 25 daily exposures to CS in 17 lambs, mean dynamic compliance was 0.024 2 0.009 liter/ cm H 2 0 , lung resistance was 2.56 + 1.32 cm H 2 0 . liter-'. s, and functional residual capacity was 0.725 + 0.234 liter. These values were not significantly different (p > 0.05) from those of the control lambs. Exposure to CS did not significantly change AR to any of the three bronchoprovocation agents tested. Histologic examination of lung tissue showed mild to moderate interstitial mononuclear cellular infiltrate, cellular debris in some airways, and occasional peribronchial inflammation in CS lambs but not in controls. Thus, passive smoking for 1 month in young lambs was not associated with a detectable alteration in lung mechanics or airway responsiveness at a time when inflammatory cells were found in the lung. (Pediatr Res 20: 853-858, 1986) Abbreviations CS, cigarette smoke COHb, carboxy hemoglobin FRC, functional residual capacity BTPS, body temperature, pressure, saturation yT, tidal volume V, flow Pa, airway opening pressure

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Distribution of pulmonary responsiveness to aerosol histamine in dogs

Cited by 49 publications

References 0 publications

Interaction of Verapamil Hydrochloride and Atropine Sulphate on Histamine-Induced Bronchoconstriction

Interaction of Verapamil Hydrochloride and Atropine Sulphate on Histamine-Induced Bronchoconstriction

Ozone Differentially Modulates Airway Responsiveness in Atopic Versus Nonatopic Guinea Pigs

Effect of Passive Smoking on the Lung of Young Lambs

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