Distribution of Quinic Acid Derivatives and Other Phenolic Compounds in Brazilian Propolis

Abstract

The quinic acid derivatives (including 4-feruoyl quinic and 5-ferruoyl quinic acids characterized for first time in propolis samples) and other phenolic compounds were quantified in thirteen Brazilian propolis samples by HPLC analysis. For chemometrical analysis, the distribution of quinic acid derivatives and other phenolic compounds were considered. The results suggest that the Brazilian propolis with floral origin from Citrus sp. have the highest concentration of the quinic acid derivatives (between 11.0 to 58.4 mg/mg of the dried crude hydroalcoholic extract) and therefore would probably show a more effective hepatoprotective activity.

Evaluation of antiulcer activity of the main phenolic acids found in Brazilian Green Propolis

“…In a previous study, our group described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis and of Baccharis dracunculifolia, the most important botanical source of Southeastern Brazilian propolis, known as green propolis for its color (Lemos et al, 2007). Some of the main compounds found in Brazilian green propolis are phenolic acids, such as: caffeic, ferulic, p-coumaric and cinnamic acids (Bankova et al, 2000;Pereira et al, 2003;Barros et al, 2007;Funari et al, 2007). Therefore, this study was undertaken to evaluate the antiulcerogenic property of the main phenolic acids found in Brazilian Green Propolis.…”

“…Analyses of its chemical composition led to the identification of at least 300 compounds (Castro, 2001). Among the main compounds found in Brazilian green propolis are phenolic acids, such as: caffeic, ferulic, p-coumaric and cinnamic acids (Bankova et al, 2000;Pereira et al, 2003;Barros et al, 2007;Funari et al, 2007).…”

Advances in the analysis of phenolic compounds in products derived from bees

“…Several authors have analysed polyphenolic compounds in propolis of diverse origins using different HPLC methods with different extraction systems and coupling diverse detector systems [62,63,100,106,109,110,112,113,115,117,119,126,134,146,[151][152][153][154][155][156][157]. Table 4 summarises the information provided by some representative papers and gives the characteristics of the column employed, the mobile phases, the type of elution employed, the detection and extraction systems used, compounds identified and several pertinent observations.…”

Análise de própolis

“…Sua composição química é variada, sendo que já foram identificadas mais de 200 substâncias em própolis de diferentes localidades, incluindo ácidos fenólicos, flavonóides, ésteres, diterpenos, sesquiterpenos, lignanas, aldeídos aromáticos, álcoois, aminoácidos, ácidos graxos, vitaminas e minerais [9,13,20,26,30,36,37,39,42,50,53,57,49,59]. Dentre estas classes de substâncias, destacam-se a dos flavonóides e a dos ácidos fenólicos, pois é atribuída a elas grande parte das atividades biológicas constatadas para a própolis.…”