F oal diarrhea is a worldwide major problem in equines and is reported to be the most common cause of death in young age (Barr, 2018; Haq et al., 2018). The affected animals show diarrhea, inappetance, and poor body condition as major clinical signs. While in some per-acute cases, high fever, leukopenia, increase heart rate, anorexia and septic shock were detected (Haq et al., 2017a). It is recorded that nearly 80% of the foals suffered from diarrhea at least one time during their life (Frederick et al., 2009). A single causative agent is often not found (Schoster et al., 2015). However, coinfection between infectious agents was recorded as being more prevalent and may result in