Distribution of rabies antigen in infected brain material: determining the reliability of different regions of the brain for the rabies fluorescent antibody test

Bingham, John; Merwe, Maria van der

doi:10.1016/s0166-0934(01)00423-2

Cited by 62 publications

(54 citation statements)

References 5 publications

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“…This was in accordance with the Barrat (1993) Bingham et al, (2002) and Iamamoto et al, (2011) findings, who stated that both techniques were equally sensitive and could be used in field conditions when a laboratory structure was not available for sampling. Field veterinarians could also adopt these techniques, as it is very simple, rapid and safe.…”

Section: Resultssupporting

confidence: 91%

Advances in Brain Specimen Collection for Rabies Diagnosis

Gandhimathy¹,

Asokkumar²

2017

Int.J.Curr.Microbiol.App.Sci

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Section: Resultssupporting

confidence: 91%

Advances in Brain Specimen Collection for Rabies Diagnosis

Gandhimathy¹,

Asokkumar²

2017

Int.J.Curr.Microbiol.App.Sci

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“…Os achados histopatológicos eram característicos de raiva e semelhantes aos observados em casos da doença em ruminantes e eqüinos (Riet-Correa et al 1983, Langohr et al 2003, Lima et al 2005, Rech et al 2006a,b, Pierezan et al 2007. As lesões eram mais concentradas na medula espinhal, seguida do tronco encefálico e do cerebelo, e refletem a distribuição antigênica e a via de entrada do vírus no SNC (Bingham & van der Merwe 2002, Swanepoel 2004. Após replicação primária em terminações nervosas próximas ao sítio de entrada, as partículas virais são transportadas via axônio para a medula espinhal e para o encéfalo, chegan-8 10 11 9 7 do primeiramente no tronco encefálico.…”

Section: Discussionunclassified

“…No entanto, foram observados CN em ambos os casos e seções de ponte e bulbo foram positivas na IHQ. Essa região (tronco encefálico) foi selecionada para IHQ por ser a área de eleição para testes de marcação antigênica em bovinos (Bingham & van der Merwe 2002). A técnica de IHQ mostrou ser específica e sensível para a confirmação do diagnóstico e vem sendo usada como ferramenta adicional no diagnóstico de raiva em humanos e animais, principalmente em casos onde há somente meningoencefalite não-supurativa, sem CN, em casos em que as técnicas de IFD e ICC resultam negativas e na realização de estudos retrospectivos de material emblocado em parafina (Jogai et al 2000, Vural et al 2001, Arslan et al 2004, Pierezan et al 2007).…”

Section: Discussionunclassified

Ocorrência de raiva em ovinos no Rio Grande do Sul

et al. 2008

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Cases of rabies in sheep occurring in November 2003, in central Rio Grande do Sul state, Brazil, are described. A 3-month-old male, and a 2.5-month-old female sheep were affected. Clinical signs were characterized by abnormal gait, trembling, lateral recumbency, convulsion, opisthotonus, and fever. Histological findings included a non-suppurative myelomeningoencephalitis associated with intracytoplasmic eosinophilic inclusion (Negri) bodies in neurons. Lesions were predominantly observed in gray matter of the spinal cord, brainstem and cerebellum. There was non-suppurative Gasserian ganglionitis in one sheep in which this structure was examined. Immunohistochemistry using rabies virus ribonucleoprotein polyclonal antibody yelded positive result in brain tissue from both sheep. The cases herein reported occurred concomitantly to an outbreak of bat transmitted rabies in cattle in the same region and were considered, on epidemiological basis, to be transmitted by bats, as occurs in endemic bovine rabies in Rio Grande do Sul.

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“…The cerebellum, hippocampus, and other parts of brain were negative in 4.5 %, 4.9 %, and 3.9 to 11.1 % of samples, respectively. The highest prevalence of antigen was seen in thalamus (97.8 %) [134].…”

Section: Postmortem Diagnosismentioning

confidence: 94%

“…The sensitivity of detection is determined by distribution of antigen within brain regions, which is highly variable. Binghem et al [134], in an elegant study, showed that sampling from thalamus, pons, and medulla is the most reliable, as samples were invariably positive in all cases. The cerebellum, hippocampus, and other parts of brain were negative in 4.5 %, 4.9 %, and 3.9 to 11.1 % of samples, respectively.…”

Section: Postmortem Diagnosismentioning

confidence: 99%

Perspectives in Diagnosis and Treatment of Rabies Viral Encephalitis: Insights from Pathogenesis

et al. 2016

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Rabies viral encephalitis, though one of the oldest recognized infectious disease of humans, remains an incurable, fatal encephalomyelitis, despite advances in understanding of its pathobiology. Advances in science have led us on the trail of the virus in the host, but the sanctuaries in which the virus remains hidden for its survival are unknown. Insights into host-pathogen interactions have facilitated evolving immunologic therapeutic strategies, though we are far from a cure. Most of the present-day knowledge has evolved from in vitro studies using fixed (attenuated) laboratory strains that may not be applicable in the clinical setting. Much remains to be unraveled about this elusive virus. This review attempts to re-examine the current advances in understanding of the pathobiology of the rabies virus that modulate the diagnosis, treatment, and prevention of this fatal disease.

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Distribution of rabies antigen in infected brain material: determining the reliability of different regions of the brain for the rabies fluorescent antibody test

Cited by 62 publications

References 5 publications

Advances in Brain Specimen Collection for Rabies Diagnosis

Advances in Brain Specimen Collection for Rabies Diagnosis

Ocorrência de raiva em ovinos no Rio Grande do Sul

Perspectives in Diagnosis and Treatment of Rabies Viral Encephalitis: Insights from Pathogenesis

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