Distribution of Radiation in Synovectomy of the Knee with <sup>166</sup>Ho-FHMA Using Image Fusion

Vuorela, Juha; Kauppinen, Tomi; Sokka, Tuulikki

doi:10.1089/cbr.2005.20.333

Cited by 7 publications

(4 citation statements)

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“…Vuorela et al did a feasibility study on six RA patients [6]. In order to localize synovitis they administered a 99m Tc-immunoglobulin [ 99m Tc-HIG] labeled anti-synovial antibody.…”

Section: Discussionmentioning

confidence: 99%

“…However, the accurate prediction of the efficacy of RSO is difficult due to patient-related factors such as the type, course, and inflammatory activity within the joint [2, 5]. On average, penetration of radiation following RSO approximates 10 mm [6, 7]. Therefore, the efficacy of RSO largely depends on the radionuclide distribution within the joint.…”

Section: Introductionmentioning

confidence: 99%

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Yttrium-90 distribution following radiosynoviorthesis of the knee joint in rheumatoid arthritis patients: a SPECT/CT study

et al. 2014

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ObjectiveTo examine yttrium-90 distribution 1 and 72 h following its injection into a knee joint in patients with rheumatoid arthritis (RA).MethodsIn 14 RA patients we injected yttrium-90 into the affected knee joint using lateral approach. To assess the radioisotope distribution in the joint, the superimposed sequential SPECT and CT imaging was performed 1 and 72 h after the injection. We analyzed the percentage of radioisotope distribution in three predefined compartments of the knee joint (lower, upper medial, upper lateral).ResultsAfter 1 and 72 h, the mean percentage distributions were, respectively, 7.14 and 23.07 % in lower; 21.42 and 15.38 % in upper medial, and 71.42 and 61.53 % in upper lateral compartment. The percentage of isotope deposition did not change significantly with time in any of the compartments (all p > 0.26). The deposition of isotope, both at 1 and 72 h, was significantly greater in upper lateral compartment, where the injection was performed, than in all other compartments (all p < 0.05).ConclusionsUsing the SPECT/CT hybrid method, we proved that the majority of isotope is located at the compartment adjacent to the injection. Two injections targeting different compartments might improve the clinical efficacy of the procedure.

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“…Vuorela et al did a feasibility study on six RA patients [6]. In order to localize synovitis they administered a 99m Tc-immunoglobulin [ 99m Tc-HIG] labeled anti-synovial antibody.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Yttrium-90 distribution following radiosynoviorthesis of the knee joint in rheumatoid arthritis patients: a SPECT/CT study

et al. 2014

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“…SPECT images were used to localize the 166 Ho, whereas the T1- weighted Gd-DTPA MR images were used to visualize the inflamed synovium. A higher uptake of 166 Ho in regions associated with a higher level of synovitis was seen (Vuorela et al 2005). Kraft et al studied the therapeutic effect of 166 Ho-labelled boron macroaggregates.…”

Section: Radiosynoviorthesismentioning

confidence: 99%

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Klaassen¹,

Arntz²,

Arranja

et al. 2019

EJNMMI radiopharm. chem.

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Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for production of nuclear reactor derived holmium-166. Several compounds labelled with holmium-166 are now used in patients, such Ho 166 -labelled microspheres for liver malignancies, Ho 166 -labelled chitosan for hepatocellular carcinoma (HCC) and [ 166 Ho]Ho DOTMP for bone metastases. The outcomes in patients are very promising, making this isotope more and more interesting for applications in interventional oncology. Both drugs as well as medical devices labelled with radioactive holmium are used for internal radiotherapy. One of the treatment possibilities is direct intratumoural treatment, in which the radioactive compound is injected with a needle directly into the tumour. Numerous other applications have been developed, like patches for treatment of skin cancer and holmium labelled antibodies and peptides. The second major application that is currently clinically applied is selective internal radiation therapy (SIRT, also called radioembolization), a novel treatment option for liver malignancies. This review discusses medical drugs and medical devices based on the therapeutic radionuclide holmium-166.

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“…Researchers from a number of disciplines have developed fusion algorithms for combining multispectral information obtained from a variety of imaging platforms to improve mapping . Recently, image fusion has been implemented in medical imaging to improve diagnostic options which has led to enhanced treatments for complex issues …”

Section: Introductionmentioning

confidence: 99%

Image fusion combining SEM and ToF-SIMS images

Milillo

Hard

Yatzor

et al. 2014

Surf. Interface Anal.

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a Image fusion allows for the combination of an image containing chemical information but low spatial resolution with a highspatial resolution image having little to no chemical information. The resulting hybrid image retains all the information from the chemically relevant original image, with improved spatial resolution allowing for visual inspection of the spatial correlations. In this research, images were obtained from two sample test grids: one of a copper electron microscope grid with a letter 'A' in the center (referred to below as the 'A-grid'), and the other a Tantalum and Silicon test grid from Cameca that had an inscribed letter 'C' (referred to below as the 'Cameca grid'). These were obtained using scanning electron microscopy (SEM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Image fusion was implemented with the Munechika algorithm. The edge resolution of the resulting hybrid image was calculated compared with the edge resolution obtained for both the individual ToF-SIMS and SEM images. The challenges of combining complimentary datasets from different instrumental analytical methods are discussed as well as the advantages of having a hybrid image. The distance across the edge for hybrid images of the A-Grid and the Cameca grid were determined to be 21 μm and 8 μm, respectively. When these values were compared to the original ToF-SIMS, SEM and optical microscopy measurements, the fused image had a spatial resolution nearly equal to that obtained in the SEM image for both samples.

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Distribution of Radiation in Synovectomy of the Knee with ¹⁶⁶Ho-FHMA Using Image Fusion

Abstract: A new method to fuse the distribution of radiation in the synovectomy of the knee was developed using SPECT/MRI image registration. Image registration of SPECT and MRI can be used to determine the activity distribution of radioisotopes in relation to synovitis.

Cited by 7 publications

References 4 publications

Yttrium-90 distribution following radiosynoviorthesis of the knee joint in rheumatoid arthritis patients: a SPECT/CT study

Yttrium-90 distribution following radiosynoviorthesis of the knee joint in rheumatoid arthritis patients: a SPECT/CT study

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Image fusion combining SEM and ToF-SIMS images

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Distribution of Radiation in Synovectomy of the Knee with 166Ho-FHMA Using Image Fusion

Abstract: A new method to fuse the distribution of radiation in the synovectomy of the knee was developed using SPECT/MRI image registration. Image registration of SPECT and MRI can be used to determine the activity distribution of radioisotopes in relation to synovitis.

Cited by 7 publications

References 4 publications

Yttrium-90 distribution following radiosynoviorthesis of the knee joint in rheumatoid arthritis patients: a SPECT/CT study

Yttrium-90 distribution following radiosynoviorthesis of the knee joint in rheumatoid arthritis patients: a SPECT/CT study

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Image fusion combining SEM and ToF-SIMS images

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Distribution of Radiation in Synovectomy of the Knee with ¹⁶⁶Ho-FHMA Using Image Fusion