Distribution of radioactive cortisol in the tissues and media of the eye

Regional Immune, Hormonal and Mediatory Mechanisms Responsible for Function of “Immune Privilege of an Eye” at Senile and Complicated Cataracts

“…The authors failed to reveal similar mechanism of reception and translocation, which is characteristic for glucocorticoids, as related to a wide range of hormones: testosterone, estradiol, progesterone, T 3 and T 4 . It was established that biological effects of cortisol are realized within the sclera, cornea, ciliary body and, mostly important, in the lens capsule (Kasavina B. et al, 1977). According to S. Rauz and associates (2001;2003), cortisol is secreted in the ciliary body of both actually healthy contingent and in patients with the primary open-angle glaucoma.…”

Modern Aspects of Glaucoma Pathogenesis Local Factors for Development of Primary Open-Angle Glaucoma Associated with Impairment of Secretory Functions of the Eye Membranes

“…At present, aspects related to studies on "endocrine homeostasis" in post-barrier membrane of an eye at both norm and pathology are the subject of a wide discussion in ophthalmology. The available publications are not numerous; furthermore, they are of a rather statement-ofthe-fact character [Southren A. et al, 1976;Floman N., Zor U., 1977;Kasavina B. et al, 1977;Weinstein B. et al, 1983;Stone R., Wilson C., 1984;Stojek A. et al, 1991;Chiquet C., Denis P., 2004;Burch J. et al, 2005;Pleyer U. et al, 2005;Schwartz B. et al, 2005;Vessey K. et al, 2005]. In particular, there are reports discussing the possibility of cortisol local synthesis in eye membranes.…”

“…In 1977, B. Kasavina et al (1977) studied cortisol distribution in sclera, ciliary body, cornea, iris, lens capsule, vitreous body and the aqueous humour. Radionuclide methods of investigation allowed to reveal that tissues and media of the eye have different intensity of cortisol absorption and excretion.…”