Distribution of Radioactivity Following Intravenous Administration of Trivalent Chromium 51 in the Rat and Rabbit.

Kraintz, Leon; Talmage, Roy V.

doi:10.3181/00379727-81-19919

Cited by 37 publications

(10 citation statements)

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“…If only a trace amount is administered, the main part is excreted by the kidneys, and the highest uptake is reported in the skeleton (400), where Cr3b inds primarily to the epiphyseal plates (401). A similar distribution is obtained if Cr3`is given as a complex, e.g., with acetate or citrate (376,401). If the complexes are even more stable, e.g., Cr-EDTA, renal excretion is total.…”

Section: Metabolism and Effects Of Similar Ionssupporting

confidence: 60%

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Metabolism and possible health effects of aluminum.

Ganrot¹

1986

Environ Health Perspect

203

150

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Literature regarding the biochemistry of aluminum and eight similar ions is reviewed. Close and hitherto unknown similarities were found. A hypothetical model is presented for the metabolism, based on documented direct observations of Al3+ and analogies from other ions. Main characteristics are low intestinal absorption, rapid urinary excretion, and slow tissue uptake, mostly in skeleton and reticuloendothelial cells. Intracellular Al3+ is probably first confined in the lysosomes but then slowly accumulates in the cell nucleus and chromatin. Large, long-lived cells, e.g., neurons, may be the most liable to this accumulation. In heterochromatin, Al3+ levels can be found comparable to those used in leather tannage. It is proposed that an accumulation may take place at a subcellular level without any significant increase in the corresponding tissue concentration. The possible effects of this accumulation are discussed. As Al3+ is neurotoxic, the brain metabolism is most interesting. The normal and the lethally toxic brain levels of Al3+ are well documented and differ only by a factor of 3-10. The normal brain uptake of Al3+ is estimated from data on intestinal uptake of Al3+ and brain uptake of radionuclides of similar ions administered intravenously. The uptake is very slow, 1 mg in 36 years, and is consistent with an assumption that Al3+ taken up by the brain cannot be eliminated and is therefore accumulated. The possibility that Al3+ may cause or contribute to some specific diseases, most of them related to aging, is discussed with the proposed metabolic picture in mind.

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Section: Metabolism and Effects Of Similar Ionssupporting

confidence: 60%

“…If the complexes are even more stable, e.g., Cr-EDTA, renal excretion is total. Independent of the mode of administration, however, shortly after the injection a high uptake is seen in the lungs and kidneys (400)(401)(402)(403). The lowest uptake is reported in the brain and muscle tissue (402).…”

Section: Metabolism and Effects Of Similar Ionsmentioning

confidence: 99%

Metabolism and possible health effects of aluminum.

Ganrot¹

1986

Environ Health Perspect

203

150

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“…It has been shown that urine is the major route for chromium secretion after intravenous injection. Kraintz and Talmage (6) detected no chromium in the feces after one day following intravenous administration. In another study (8) where 51 Cr as chloride was injected intravenously, 13.5-14.3% of the dose appeared in the feces.…”

mentioning

confidence: 96%

“…A number of studies on the distribution and metabolism of chromium have been done in normal and pathological conditions utilizing quantitative radiobiological methods (1,3,6,7,12,13,14,16). As yet, however, many aspects of the chromium behavior are still not sufficiently known.…”

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confidence: 99%

Radioautographic Observations on the Uptake and Distribution of Chromium-51 in Mice

Söremark¹,

Diab²

1972

Nuklearmedizin

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SummaryThe distribuition of 51Cr has been studied in mice by whole-body radioautography after a single intravenous injection of 51CrCl3.Hard tissues, skin, liver, cartilage and yolk sack epithelium were the tissues showing the highest concentration of radiochromium. Blood, brain, muscles and the pancreas showed a low uptake of 51Cr. A placental transfer of chromium from the pregnant mother to the fetus was demonstrated. An uptake in the fetal bone and skin was visible.

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“…logical distribution have been surprisingly few. Available knowledgt is mostly based on studies on rats (Kraintz & Talmage 1952, Scott 1950Visek et al 1953 ; there are also a few data on dogs and sheep (Grab & Sterling 1950, Visek et al 1953). Only two rabbits could be founc reported in the literature (Kraintz & Talmaye 1952), and then somt species differences from rats were found.…”

mentioning

confidence: 99%

DISTRIBUTION OF TRIVALENT ⁵¹Cr IN THE RABBIT; ITS POSSIBLE USE AS AN INDICATOR OF THE BLOOD‐BRAIN BARRIER

Edström

1959

Acta Psychiatr Scand

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Distribution of Radioactivity Following Intravenous Administration of Trivalent Chromium 51 in the Rat and Rabbit.

Cited by 37 publications

References 1 publication

Metabolism and possible health effects of aluminum.

Metabolism and possible health effects of aluminum.

Radioautographic Observations on the Uptake and Distribution of Chromium-51 in Mice

DISTRIBUTION OF TRIVALENT ⁵¹Cr IN THE RABBIT; ITS POSSIBLE USE AS AN INDICATOR OF THE BLOOD‐BRAIN BARRIER

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Distribution of Radioactivity Following Intravenous Administration of Trivalent Chromium 51 in the Rat and Rabbit.

Cited by 37 publications

References 1 publication

Metabolism and possible health effects of aluminum.

Metabolism and possible health effects of aluminum.

Radioautographic Observations on the Uptake and Distribution of Chromium-51 in Mice

DISTRIBUTION OF TRIVALENT 51Cr IN THE RABBIT; ITS POSSIBLE USE AS AN INDICATOR OF THE BLOOD‐BRAIN BARRIER

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DISTRIBUTION OF TRIVALENT ⁵¹Cr IN THE RABBIT; ITS POSSIBLE USE AS AN INDICATOR OF THE BLOOD‐BRAIN BARRIER