Distribution of radiolabelled azelaic acid in eye membranes and fluids of rabbits

Mingrone, Geltrude; Greco, Alberto; A, Ciardiello; Passo, S.; Nazzaro‐Porro, M.

doi:10.1016/s0232-1513(84)80012-2

Cited by 4 publications

(1 citation statement)

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“…A cytotoxic effect on human melanocytes and a much higher capacity to penetrate abnormal cells than normal cells indicated possibilities for use in treating melanoma at one time. However, these hopes were dashed [82,83]. From a practical standpoint, very few cosmetics use this acid.…”

Section: Tyrosinase Inhibitorsmentioning

confidence: 99%

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

2016

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Depigmentation and skin lightening products, which have been in use for ages in Asian countries where skin whiteness is a major esthetic criterion, are now also highly valued by Western populations, who expose themselves excessively to the sun and develop skin spots as a consequence. After discussing the various possible mechanisms of depigmentation, the different molecules that can be used as well as the status of the products containing them will now be presented. Hydroquinone and derivatives thereof, retinoids, alpha-and beta-hydroxy acids, ascorbic acid, divalent ion chelators, kojic acid, azelaic acid, as well as diverse herbal extracts are described in terms of their efficacy and safety. Since a genuine effect (without toxic effects) is difficult to obtain, prevention by using sunscreen products is always preferable.

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Section: Tyrosinase Inhibitorsmentioning

confidence: 99%

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

2016

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Azelaic Acid: Pharmacokinetic and Pharmacodynamic Properties and Its Therapeutic Role in Hyperpigmentary Disorders and Acne

Nguyen

Bui

1995

Int J Dermatology

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Azelaic Acid

Fitton¹,

Goa²

1991

Drugs

201

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Azelaic acid is a naturally occurring saturated dicarboxylic acid which, on topical application (usually as a 20% cream), has been shown to be effective in the treatment of comedonal acne and inflammatory (papulopustular, nodular and nodulocystic) acne, as well as various cutaneous hyperpigmentary disorders characterised by hyperactive/abnormal melanocyte function, including melasma and, possibly, lentigo maligna. In addition, azelaic acid has an antiproliferative and cytotoxic effect on the human malignant melanocyte, and preliminary findings indicate that it may arrest the progression of cutaneous malignant melanoma. The mechanism of this selective cytotoxic action of azelaic acid is unclear, but may possibly be related to its inhibition of mitochondrial oxidoreductase activity and DNA synthesis. In controlled studies, topical azelaic acid demonstrated comparable anti-acne efficacy to topical tretinoin, benzoyl peroxide, erythromycin and oral tetracycline, while in patients with melasma azelaic acid proved at least as effective as topical hydroquinone. On topical application azelaic acid is well tolerated, with adverse effects apparently limited to a generally mild and transient local cutaneous irritation. Thus, topical azelaic acid, employed either as monotherapy or in combination with other treatments, is likely to prove of value in the management of acne and several hyperpigmentary disorders, most notably melasma.

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Distribution of radiolabelled azelaic acid in eye membranes and fluids of rabbits

Cited by 4 publications

References 1 publication

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

Azelaic Acid: Pharmacokinetic and Pharmacodynamic Properties and Its Therapeutic Role in Hyperpigmentary Disorders and Acne

Azelaic Acid

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