Distribution of Retinal Layer Atrophy in Patients With Parkinson Disease and Association With Disease Severity and Duration

García‐Martín, Elena; Larrosa, José M.; Polo, Vicente; Satué, María; Marques, Marcia L.; Alarcia, Raquel; Seral, M; Fuertes, Isabel; Otı́n, Santos; Júlvez, Luis Pablo

doi:10.1016/j.ajo.2013.09.028

Cited by 138 publications

(132 citation statements)

References 33 publications

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“…To date, only one other study has reported intra-retinal segmentation of all the retinal layers individually in PD [28]. Using the same machine and segmentation software as ours, Garcia-Martin et al also detected significant thinning of the GCL and IPL in patients with PD compared to HC.…”

Section: Discussionsupporting

confidence: 53%

“…This was a cross-sectional study in a relatively small number of eyes (101) in 52 patients with PD. However, other than the study by Garcia-Martin et al [28], most OCT studies in PD have included similar or fewer numbers of patients [3,17,24,25]. We believe that a larger number of PD patients across different disease stages studied prospectively would provide greater confidence in our findings.…”

Section: Discussionmentioning

confidence: 69%

See 1 more Smart Citation

Characterization of retinal architecture in Parkinson's disease

Chorostecki¹,

Seraji‐Bozorgzad²,

Shah³

et al. 2015

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 69%

Characterization of retinal architecture in Parkinson's disease

Chorostecki¹,

Seraji‐Bozorgzad²,

Shah³

et al. 2015

Journal of the Neurological Sciences

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“…Equally Feng et al [17] demonstrated in Chinese people with MS the thinning of RNFL with SDOCT and they suggested the use of the tomography as a high-resolution, objective, noninvasive, and easily quantifiable in vivo biomarker of MS. OCT is a rapid high-resolution method to obtain morphological and quantitative information that could be important in the management and follow-up of patients with neurodegenerative diseases such as CMI or SM. At least looking at the studies of Garcia-Martin and her research group in Saragoza [18, 19], we obtain a confirmation of what we have already discussed for MS, because the analysis based on the segmentation technologies of the Spectralis OCT (Heidelberg Engineering, Inc., Heidelberg, Germany) showed retinal layer atrophy in patients with MS, especially of the inner layers. They observed also the reduction of the ganglion cell and inner plexiform layer as predictor of greater axonal damage.…”

Section: Discussionsupporting

confidence: 77%

Optical Coherence Tomography in Patients with Chiari I Malformation

Figus

Posarelli

Nasini

et al. 2015

BioMed Research International

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Background/Aims. To evaluate optic nerve head with spectral domain optical coherence tomography (OCT) in patients with Chiari I malformation (CMI) compared to healthy controls. Methods. Cross-sectional study. OCT of the optic nerve head of 22 patients with CMI and 22 healthy controls was quantitatively analyzed. The healthy controls were matched for age and sex with the study population. Mean retinal nerve fiber layer (RNFL) thickness was calculated for both eyes; the mean thickness value was also registered for each quadrant and for each subfield of the four quadrants. Results. CMI patients showed a reduction of the RNFL thickness in both eyes. This reduction was more statistically significant (P < 0.05) for the inferior quadrant in the right eye and in each quadrant than nasal one in the left eye. Conclusion. A distress of the retinal nerve fibers could explain the observed reduction of the RNFL thickness in patients with CMI; in our series the reduction of the RNFL thickness seems lower when CMI is associated with syringomyelia.

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“…Many studies have reported on the retinal degeneration in PD, particularly thinning of the RNFL and loss of ganglion cells. [23][24][25] However, just one article has reported on the retinal vascular abnormalities in PD. 26 OCT-A is a new advanced imaging technology that enables the noninvasive imaging of the retinal capillaries; it is especially useful for the in-depth analysis of retinal vessels in multiple layers that were previously invisible on the fundus images.…”

Section: Discussionmentioning

confidence: 99%

Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease

Kwapong

Peng

et al. 2018

Invest. Ophthalmol. Vis. Sci.

101

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PURPOSE. To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find a correlation between the microvascular impairment and the neuronal damage.METHODS. This is a prospective, observational study including 49 eyes from 38 PD patients in their early stages and 34 eyes from 28 healthy controls with comparable age range. Macula microvasculature was evaluated with the spectral-domain optical coherence tomography (SD-OCT) angiography and intraretinal layer thickness evaluated with the SD-OCT. A custom algorithm was used for custom segmentation of retinal thickness and quantification of the superficial and deep microvascular density of the macula, respectively.RESULTS. PD patients showed reduced microvascular density in most of the areas of the whole retina. In the superficial retinal capillary plexus, statistical difference (P < 0.01) was seen in the total annular zone (TAZ), superior, temporal, inferior, and nasal zones. In PD patients, there was a strong correlation between the average ganglion cell layer and inner plexiform (GCIP) thickness and the TAZ of the superficial microvascular density (r ¼ 0.062, P ¼ 0.032).CONCLUSION. We demonstrated that retinal microvascular density decreased in PD patients. The correlation between microvascular impairment in the superficial retinal capillary layer and GCIP thinning also revealed that the retinal microvascular abnormality may contribute to the neurodegeneration in PD patients. OCT-A with quantitative analysis offers a new path of study and will likely be useful in the future as an objective biomarker for detecting vessel impairment in early stages of PD.

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Distribution of Retinal Layer Atrophy in Patients With Parkinson Disease and Association With Disease Severity and Duration

Cited by 138 publications

References 33 publications

Characterization of retinal architecture in Parkinson's disease

Characterization of retinal architecture in Parkinson's disease

Optical Coherence Tomography in Patients with Chiari I Malformation

Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease

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