Distribution of Rhodium in Mice Submitted to Treatment With the Adduct of Rhodium Propionate and Sodium Isonicotinate

Abstract

The distribution of rhodium in Balb/c mice following intraperitoneal (ip) administration of a solution of adduct of rhodium propionate and sodium isonicotinate has been investigated. The metal concentration was determined in blood and in the following organ tissues: brain, heart, lung, liver, spleen, kidney, testes, and uterus/ovary, and the rhodium concentration was obtained by Inductively Coupled Argon Atomic Emission Spectroscopy (ICP-AES). The metal was detected in all organ tissues examined, mainly in spleen, liver, uterus/ovary and heart. Nine days after the injection, traces of rhodium were found in the liver and kidneys and, twenty days after the injection, only in the liver.

Effects of human serun albumin in some biological properties of rhodium(II) complexes

“…It was assumed only one kind of interaction between the albumin and the rhodium complex [Rh 2 (bridge) 4 ], according to the following equation:…”

“…The rhodium concentration in the diluted supernatants was determined by means of the ICP-AES technique. 4 ]. Previous assays showed HSA to be innocuous to the mice.…”

“…The meaningfulness of the survival patterns of the two groups (displayed in KaplanMeier plots) was tested by the Mantel-Haenszel method 30 . A similar procedure was employed to assess the activity of the unbound [Rh 2 (tfc) 4 …”

“…Both their antibacterial and antitumoral actions to human and murine cell lines have been a target of research [1][2][3] . Moreover, the biodistribution of these complexes was studied with more detail recently 4 , meeting the current interest in the factors that could affect the availability of these drugs to tumor cells.…”

Interaction of [Rh2(O2CCH3)4(H2O)2] and [Rh2(O2CCH(OH)Ph)2(phen)2(H2O)2](O2C‐CH(OH)Ph)2 With Sulfhydryl Compounds and Ceruloplasmin

“…Rhodium(II) carboxylato complexes belong to the most promising platinum metals compounds having anticancer and biological activity [14][15][16][17][18][19][20][21]. These results have prompted investigations into the chemical properties and biological effects of rhodium(II) complexes 14-16, 2+ [20][21][22][23][24][25][26]. It has been found [27][28] that [Rh2(OOCR)2(N-N)(HO)] complexes show cytostatc activity against human oral carcinoma KB cell line in vitro.…”