Distribution of semduramicin in hen eggs and tissues after administration of cross-contaminated feed

Abstract

Semduramicin is an ionophore coccidiostat used in the poultry industry as a feed additive. Cross-contamination of feeds for non-target animals with semduramicin is unavoidable. However, it is not known whether undesirable residues of semduramicin may occur in food after cross-contaminated feed is administered to animals. The aim of the work was to determine the levels of semduramicin in hen eggs (yolks and albumen) and tissues (liver, muscle, spleen, gizzard, ovarian yolks and ovaries) after administration of feed contaminated with 0.27 mg kg(-1) of this coccidiostat. The residues were determined using LC-MS/MS. The distribution pattern confirmed the high lipophilicity of semduramicin. Residues were found mainly in egg yolks (28.8 µg kg(-1)), ovarian yolks (19.5 µg kg(-1)) and liver (2.57 µg kg(-1)), while hens' muscle was free from semduramicin (LOD = 0.1 µg kg(-1)). Among edible tissues, the maximum level (2 µg kg(-1)) was exceeded only in the liver.

Incidence of ionophore and non-ionophore anticoccidials residues in poultry meat and eggs and their risk characterization

“…The molecules primarily used consisted of synthetic non-ionophore anticoccidials such as halofuginone (HFG), robenidine (ROB), diclazuril (DIC), decoquinate (DEC) and nicarbazin (NIC) and, from 1970s, of naturally occurring polyether ionophores, such as monensin (MON), narasin (NAR), lasalocid (LAS), salinomycin (SAL), semduramicin (SEM) and maduramicin (MAD) (Chapman, 2009 ). Humans can be exposed to residues of such molecules as a consequence of feeding cross-contaminated feed to food-producing animals (Olejnik et al ., 2014 ). Albeit coccidiostats are authorized as feed additives for target animal species by European legislation (Regulation (EC) No.…”