Distribution of serotonin-immunoreactivity in the brain of the pigeon (Columba livia)

Challet, Étienne; Miceli, D.; Pierre, J.; Repérant, J; Masicotte, G.; Herbin, Marc; Vesselkin, N. P.

doi:10.1007/bf00198325

Cited by 66 publications

(62 citation statements)

References 45 publications

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“…The highest density was found in the PT. This is in line with the dense innervation of the avian PT by serotonergic fibers (Cozzi et al, 1991;Challet et al, 1996;Metzger et al, 2002). Since PT is the source of visual and nonvisual input to the superficial layers of the optic tectum, it may modulate the inhibitory control of retinotectal transmission (Gamlin and Cohen, 1988;Gamlin et al, 1996) through 5-HT 1A receptors.…”

Section: Discussionsupporting

confidence: 59%

“…They were particularly prominent in several structures of the telencephalon (arcopallium pars dorsalis, nucleus taeniae, area parahippocampalis, septum), diencephalon (nuclei preopticus medianus, magnocellularis, nucleus geniculatus lateralis pars ventralis, nucleus triangularis, nucleus pretectalis), mesencephalonrhombencephalon (superficial layers of the optic tectum, nucleus of the basal optic root, nucleus isthmo-opticus), and in most of the cranial nerve nuclei (Krebs et al, 1991;Challet et al, 1996). To date, detailed information about the distribution of 5-HT receptors in the avian brain is very sparse.…”

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confidence: 99%

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Serotonin 5-HT1A receptor binding sites in the brain of the pigeon (Columba livia)

et al. 2012

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Serotonin (5-HT) is a modulatory neurotransmitter that is involved in a variety of physiological and behavioral functions. In mammals, dysfunction of the serotonergic system has been linked to various diseases such as depression, schizophrenia, Alzheimer's disease, and eating disorders (Müller et al., 2007;Michelsen et al., 2008;Remington, 2008;Terry et al., 2008;Akimova et al., 2009;Polter and Li, 2010). In addition, growing evidence found in many species indicates that 5-HT modulates learning and memory (Jacobs and Azmitia, 1992;Winsauer et al., 1996; Meneses, 1999;Clarke et al., 2004; Meneses and PerezGarcia, 2007;Müller et al., 2007;Bert et al., 2008;Gasbarri et al., 2008;González-Burgos and Feria-Velasco, 2008;Sitaraman et al., 2008;Sambeth et al., 2009;Bari et al., 2010).Serotonin binds to multiple receptors (Hoyer et al., 2002;Green, 2006), which are widely distributed throughout the brain (Chalmers and Watson, 1991;Baumgarten and Grozdanovic, 1995;Barnes and Sharp, 1999;Riad et al., 2000). One of the most prominent is the 5-HT 1A receptor, which was first cloned and described by Fargin et al. (1988). The 5-HT 1A receptor belongs to the G protein coupled receptor superfamily and binds to a Gi/o protein (Innis and Aghajanian, 1987;Polter and Li, 2010). It displays a high affinity for 5-HT and occurs both pre-and postsynaptically (Hall et al., 1985;van Wijngaarden et al., 1990;Riad et al., 2000). As somatodendritic autoreceptors, 5-HT 1A receptors modulate the activity of 5-HT neurons, whereas they modify neuronal activity in terminal areas as postsynaptic receptors (Müller et al., 2007).The distribution of 5-HT 1A receptors in the brain has been investigated by several methods in rodents, nonhuman primates, and humans. Thereby, a high correlation between receptor binding with [3H]-8-hydroxy-2-(di-n-propylamino)tetralin ([ 3 H]-8-OH-DPAT) and 5-HT 1A mRNA densities has been shown (Chalmers and Watson, 1991;Pompeiano et al., 1992). High 5-HT 1A receptor densities were detected in the dorsal and median raphe nuclei and in areas of the limbic system such as the hippocampus, the lateral septum, the amygdala, as well as the entorhinal and cingulate cortices Zilles et al., 1985Zilles et al., , 2000Palacios et al., 1990;Yilmazer-Hanke et al., 2003). Moderate binding was detected in the olfactory bulb, the thalamus, hypothalamus, and several brain stem nuclei as well as neocortical areas. Low levels, or no binding, were reported in the basal ganglia and cerebellum (Gozlan et al., 1983;Marcinkiewicz et al., 1984;Zilles et al., 1985Zilles et al., , 2000Hall et al., 1997;Vergé et al., 1986;Albert et al., 1990;Palacios et al., 1990;Pompeiano et al., 1992;Khawaja, 1995; Kia et al., 1996a,b;Farde et al., 1997;Raurich et al., 1999;Hume et al., 2001;Maeda et al., 2001;Geyer et al., 2005;Palchaudhuri and Flügge, 2005;Eickhoff et al., 2007;Topic et al., 2007). 5-HT 1A receptors play a role in executive functions, anxiety related behavior, learning and reinforcement, feeding behavior, and locomotor activity (Zilles et al., 2...

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Section: Discussionsupporting

confidence: 59%

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Serotonin 5-HT1A receptor binding sites in the brain of the pigeon (Columba livia)

et al. 2012

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“…The topographic and functional organization of the serotonergic system has been highly conserved from reptiles to birds and mammals (Dubé & Parent, 1981;Parent, 1981;Parent et al, 1981;Duchala et al, 1984;Sako et al, 1986;Cozzi et al, 1991;Challet et al, 1996). In fact, the ubiquitous phylogenetic distribution of the serotonergic system has raised the hypothesis that this system represents a neural substrate integrating similar mechanisms that remain intact throughout the vertebrate kingdom (Parent, 1981).…”

Section: Introductionmentioning

confidence: 99%

“…In birds, a dense serotonergic-fiber distribution has been identified in diencephalic regions known to be involved in controlling feeding behavior (Parent, 1981;Duchala et al, 1984;Sako et al, 1986;Challet et al, 1996). However, studies regarding the role of serotonergic pathways in the control of food intake in birds are rare (Rosebrough, 1996;Thomaz et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Evidence indicating participation of the serotonergic system in controlling feeding behavior in Coturnix japonica (Galliformes: Aves)

Reis

Almeida²,

Cedraz-Mercez³

et al. 2005

Braz. J. Biol.

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We investigated participation of the brain serotonergic system in food intake control by using oral and systemic administration of serotonin precursors in quails (Coturnix japonica). Dietary supplemental tryptophan (0.1-50.0 g/kg) provoked a dose-dependent inhibition of food intake during a 5-h observation period, which persisted up to 24 h for doses of 30.0 and 50.0 g/kg. Normally fed and fasted animals treated with hydroxytryptophan (12.5-50.0 mg/kg) by the intracoelomic route showed an acute inhibition of food intake. Hypophagia in fasted birds was only effective when the precursor was administered immediately before food presentation. A similar response was obtained by administering serotonin (0.125-2.5 mg/kg, sc), with animals showing a hypnogenic response within the first ten minutes after administration, suggesting that, in contrast to mammals, the amine crosses the bloodbrain barrier in quails. Administration of hydroxytryptophan at all doses tested induced significant dipsogenic behavior despite the concomitant hypnogenic response. The results suggest the involvement of serotonergic pathways in food intake control in quails and also show, for the first time, hypnogenic action induced by serotonin and a hyperdipsic effect elicited by hydroxytryptophan.Key words: feeding behavior, serotonergic system, tryptophan, hydroxytryptophan, serotonin, Coturnix japonica. RESUMO Evidência da participação do sistema serotonérgico no controle do comportamento alimentar em Coturnix japonica (Galliformes: Aves)Investigamos a participação do sistema serotonérgico cerebral no controle da ingestão de alimento em codornas (Coturnix japonica) por meio da administração oral e sistêmica de precursores da serotonina. A suplementação dietética com triptofano (0,1-50,0 g/kg de ração) provocou inibição dose-dependente da ingestão de alimento em 5 h de avaliação, que se manteve ao final de 24 h com doses de 30,0 e 50,0 g/kg. Codornas tratadas com hidroxitriptofano (12,5-50,0 mg/kg, via intracoelomática) exibiram aguda inibição da ingestão alimentar, tanto as normoalimentadas quanto as submetidas ao jejum. Nas aves em jejum, a resposta hipofágica foi efetiva apenas quando a administração do precursor foi feita imediatamente antes da oferta de alimento. Resposta similar foi alcançada com a administração de serotonina (0,125-2,5 mg/kg, sc). Nos minutos iniciais após a administração desenvolveu-se resposta hipnogênica, implicando assunção de que essa amina atravessa a barreira hemato-encefálica em codornas, Braz. J. Biol., 65(2)

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“…The topographic and functional organization of the serotonergic system in birds maintained homologies with reptiles and mammals (Dubé & Parent, 1981;Parent, 1981;Parent et al, 1981;Duchala et al, 1984;Sako et al, 1986;Cozzi et al, 1991;Challet et al, 1996;Gruss & Braun, 1997). However, studies about the participation of serotonin receptors in the feeding behavior of quails (Coturnix japonica) are absent from the literature, although receptors for serotonin have been identified in bird brains (Gleeson et al, 1992;Saadoun & Cabrera, 2002).…”

Section: Introductionmentioning

confidence: 99%

Influence of 5-HT1A agonist on the feeding behavior of Coturnix japonica (Galliformes: Aves)

Reis¹,

Marinho

2005

Braz. J. Biol.

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In this study, we investigate the effect of serotonin receptor 5-HT1A stimulation on the feeding behavior of quails (Coturnix japonica). The administration of 5-HT1A agonist, 8-OH-DPAT (0.05 to 5.0 mg/Kg) dose-dependently inhibited the food intake in normally fed quails. Greater inhibition was attained with 5.0 mg/kg (0.93 ± 0.21 g vs. 5.83 ± 0.25 g, P < 0.05, 2 h after food offer). A comparable response was obtained from previously fasted quails. At end of 2 h, a higher dose of 8-OH-DPAT induced more intense hypophagy (1.59 ± 0.41 g vs. 6.85 ± 1.04 g, P < 0.0001). Previous treatment with the antagonist 5-HT1A/β-adrenergic, propranolol, failed to block the inhibitory action of 8-OH-DPAT, but instead, intensified it (controls, 5.22 ± 1.09 g; 8-OH-DPAT, 1.41 ± 0.19 g; propranolol + 8-OH-DPAT, 0.44 ± 0.25 g, P < 0.01, for all comparisons). The administration of an isolated higher dose of propranolol induced a hypophagic action (controls, 4.5 ± 0.8 g vs. propranolol, 2.0 ± 0.2 g, P < 0.01). Current outcomes suggest a possible role of 5-HT1A receptor on the feeding behavior of quails, as opposed to mammals. On the other hand, the intensified hypophagy induced by previous administration of propranolol raises the hypothesis of a β-adrenergic excitatory mechanism that controls the feeding behavior of quails.Keywords: feeding behavior, 5-HT1A receptor, serotonergic system, quails, Coturnix japonica. 5,83 ± 0,25 g, P < 0,05, 2 h após a oferta de alimento). Resposta comparável foi alcançada nas aves previamente submetidas ao jejum alimentar. Ao final de 2 h, a dose maior de 8-OH-DPAT induziu a uma intensa resposta hipofágica (1,59 ± 0,41 g vs. 6,85 ± 1,04 g, P < 0,0001). O tratamento prévio com o antagonista 5-HT1A/β-adrenérgico, propranolol, não bloqueou a ação inibidora do 8-OH-DPAT na ingestão alimentar, ao contrário, intensificou-a (controles, 5,22 ± 1,09 g; 8-OH-DPAT, 1,41 ± 0,19 g; propranolol + 8-OH-DPAT, 0,44 ± 0,25 g, P < 0,01, para todas as comparações). A administração isolada de propranolol evidenciou uma ação hipofágica com a dose maior (controles, 4,5 ± 0,8 g vs. propranolol, 2,0 ± 0,2 g, P < 0,01). Os resultados obtidos evidenciaram um possível papel dos receptores 5-HT1A na modulação do comportamento alimentar em codornas de natureza oposta ao referido para mamíferos. Por outro lado, a potencialização da hipofagia pela prévia administração de propranolol suscita a hipótese de um mecanismo β-adrenérgico excitatório no controle do comportamento alimentar em codornas. RESUMO

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Distribution of serotonin-immunoreactivity in the brain of the pigeon (Columba livia)

Cited by 66 publications

References 45 publications

Serotonin 5-HT1A receptor binding sites in the brain of the pigeon (Columba livia)

Serotonin 5-HT1A receptor binding sites in the brain of the pigeon (Columba livia)

Evidence indicating participation of the serotonergic system in controlling feeding behavior in Coturnix japonica (Galliformes: Aves)

Influence of 5-HT1A agonist on the feeding behavior of Coturnix japonica (Galliformes: Aves)

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