Distribution of Smooth Muscle Cells and Macrophages Expressing Scavenger Receptor BI/II in Atherosclerosis

Ishikawa, Yukio; Kimura-Matsumoto, M; Murakami, Makoto; Yamamoto, Kei; Akasaka, Yoshikiyo; Uzuki, Miwa; Yuri, Yuri; Inomata, Naomi; Yokoo, Tomoko; Ishii, Toshiharu

doi:10.5551/jat.1941

Cited by 18 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SR-B1 gene product binds HDL, viruses and bacteria; mutations or allelic variations in SR-B1 are associated with an increased risk of atherosclerosis, infertility and/or an impaired innate immune response [ 36 , 37 , 38 ]. The SR-B3 ( SCARB2 ) gene is on human chromosome 4 and expressed in liver, brain, heart and macrophages; the SR-B3 protein mediates binding to HDL particles [ 39 , 40 ]. The SR-B2 ( CD36 ) gene is on human chromosome 7 and widely expressed.…”

Section: Class Bmentioning

confidence: 99%

Scavenger Receptor Structure and Function in Health and Disease

Zani

Stephen

Mughal

et al. 2015

Cells

290

219

View full text Add to dashboard Cite

Scavenger receptors (SRs) are a ‘superfamily’ of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous proteins and pathogens. New family of SRs and their properties have been identified in recent years, and have now been classified into 10 eukaryote families, defined as Classes A-J. These receptors are classified according to their sequences, although in each class they are further classified based in the variations of the sequence. Their ability to bind a range of ligands is reflected on the biological functions such as clearance of modified lipoproteins and pathogens. SR members regulate pathophysiological states including atherosclerosis, pathogen infections, immune surveillance, and cancer. Here, we review our current understanding of SR structure and function implicated in health and disease.

show abstract

Section: Class Bmentioning

confidence: 99%

Scavenger Receptor Structure and Function in Health and Disease

Zani

Stephen

Mughal

et al. 2015

Cells

290

219

View full text Add to dashboard Cite

show abstract

“…Once numerous SMCs migrate to the intima, their excessive proliferation and apoptosis suppression promote extracellular matrix synthesis and lipid deposition, consequently facilitating arterial wall fibrosis and thickening and the luminal stenosis. First, Ruan et al and Ishikawa et al demonstrated that human SMCs express numerous lipid uptake receptors, such as low-density lipoprotein receptor (LDLR) and SR, contributing to the formation of myogenic FCs [28, 29]. Second, SMC proliferation can be inhibited by NO, which is a key component of arterial vessel wall remodeling in response to injury, for example, after angioplasty or vein grafting and during atherosclerosis formation [30].…”

Section: The Media In the Progression Of Atherosclerosismentioning

confidence: 99%

Roles of Cells from the Arterial Vessel Wall in Atherosclerosis

Wang

Zhang

et al. 2017

Mediators of Inflammation

View full text Add to dashboard Cite

Atherosclerosis has been identified as a chronic inflammatory disease of the arterial vessel wall. Accumulating evidence indicates that different cells from the tunica intima, media, adventitia, and perivascular adipose tissue not only comprise the intact and normal arterial vessel wall but also participate all in the inflammatory response of atherosclerosis via multiple intricate pathways. For instance, endothelial dysfunction has historically been considered to be the initiator of the development of atherosclerosis. The migration and proliferation of smooth muscle cells also play a pivotal role in the progression of atherosclerosis. Additionally, the fibroblasts from the adventitia and adipocytes from perivascular adipose tissue have received considerable attention given their special functions that contribute to atherosclerosis. In addition, numerous types of cytokines produced by different cells from the arterial vessel wall, including endothelium-derived relaxing factors, endothelium-derived contracting factors, tumor necrosis factors, interleukin, adhesion molecules, interferon, and adventitium-derived relaxing factors, have been implicated in atherosclerosis. Herein, we summarize the possible roles of different cells from the entire arterial vessel wall in the pathogenesis of atherosclerosis.

show abstract

“…However discrepant data were reported from in vitro studies performed with SMCs and macrophages as well as in ex vivo investigations on arteries exhibiting different size of atherosclerotic plaque formation and disease progression. Some studies revealed increased expressions of ABCA1 and ABCG1 in arteries whereas in others ABCA1, ABCG1 and SR-B1 expressions were diminished [94][95][96][97][98].…”

Section: Cyclodextrins and Atherosclerosismentioning

confidence: 99%

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

et al. 2016

View full text Add to dashboard Cite

Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism. Therefore, innovative pharmacological approaches aiming at counteracting cholesterol imbalance display promising therapeutic potential. However, these approaches need to take into account the existence of biological barriers such as intestinal and blood-brain barriers which participate in the organ homeostasis and are major defense systems against xenobiotics. Interest in cyclodextrins (CDs) as medicinal agents has increased continuously based on their ability to actively extract lipids from cell membranes and to provide suitable carrier system for drug delivery. Many novel CD derivatives are constantly generated with the objective to improve CD bioavailability, biocompatibility and therapeutic outcomes. Newly designed drug formulation complexes incorporating CDs as drug carriers have demonstrated better efficiency in treating cardiovascular and neurodegenerative diseases. CD-based therapies as cholesterol-sequestrating agent have recently demonstrated promising advances with KLEPTOSE ® CRYSMEB in atherosclerosis as well as with the 2-hydroxypropyl-β-cyclodextrin (HPβCD) in clinical trials for Niemann-Pick type C disease. Based on this success, many investigations evaluating the therapeutical beneficial of CDs in Alzheimer's, Parkinson's and Huntington's diseases are currently on-going.

show abstract

Distribution of Smooth Muscle Cells and Macrophages Expressing Scavenger Receptor BI/II in Atherosclerosis

Abstract: The results indicated that SMCs are involved in lipid metabolism via SRBI/II expression mainly in the early stages of atherosclerosis evolution, and that SRBI/II-positive macrophages are mainly involved in advanced stages.

Cited by 18 publications

References 34 publications

Scavenger Receptor Structure and Function in Health and Disease

Scavenger Receptor Structure and Function in Health and Disease

Roles of Cells from the Arterial Vessel Wall in Atherosclerosis

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

Contact Info

Product

Resources

About