DISTRIBUTION OF <sup>125</sup>I‐IMMUNOGLOBULINS, IgG SUBUNITS AND ANTIGEN‐ANTIBODY COMPLEXES IN RAT LYMPH NODES

Herd, Zana L.; Ada, G. L.

doi:10.1038/icb.1969.6

Cited by 29 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…i-FDRCs bind Fc but not the Fab fragments of IgG and therefore seem to have an Fc receptor (Herd & Ada 1969). Tbe absence of C3 in the serum appears to have a negative influence on the localization of immune complexes in the follicles of spleen (Papamichael et aL 1975, Tew et al 1979).…”

Section: Interdigitating Reticulum Cells (Ircs)mentioning

confidence: 99%

Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to Macrophages

Silbernirg-Sinakrn

Gmlgli

Balr

et al. 1980

Immunological Reviews

143

View full text Add to dashboard Cite

Section: Interdigitating Reticulum Cells (Ircs)mentioning

confidence: 99%

Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to Macrophages

Silbernirg-Sinakrn

Gmlgli

Balr

et al. 1980

Immunological Reviews

143

View full text Add to dashboard Cite

“…Two sorts of experiments were attempted to find out what components of an immune complex were responsible for binding to FDC's. Earlier workers emphasized the requirement for specific antibody, probably the F~ portion (16,19,21). We found that F(ab')2 anti-HRP-HRP complexes exhibited greatly reduced association with FDC's.…”

Section: Mechanism Of Immune Complex Retention On Fdc'smentioning

confidence: 99%

Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells.

Chen¹,

Frank²,

Adams³

et al. 1978

The Journal of Cell Biology

View full text Add to dashboard Cite

The distribution of immune complexes has been studied in mouse spleen stimulated to contain many germinal centers (GC's). Horseradish peroxidase (HRP)-anti-HRP complexes were used as an appropriately precise and sensitive model. We were primarily interested in the relative abilities of three cell types to interact with complexes: lymphocytes, macrophages, and follicular dendritic cells (FDC's). The latter are distinctive, nonendocytic, stellate cells located primarily at the transition of mantle and GC zones of 2 ~ lymphoid follicles (Chen, L. L., J. C. Adams, and R. M. Steinman, 1978, J. Cell Biol. 77"148).Binding of immune complexes to lymphocytes could not be visualized in situ. Macrophages avidly interiorized complexes into lysosomes, but did not retain them extracellularly. In contrast, FDC's could retain HRP-anti-HRP extracellulady under appropriate conditions, but did not endocytose them. Cytochemical reactivity accumulated progressively on FDC's 1-6 h after administration of complexes i.v., remained stable in amount and location for 1 day, and then was progressively lost over a 1-to 5-day period.Several variables in the association of complexes with macrophages and FDC's were pursued. Only 1 /~g of complexed HRP had to be administered to visualize binding to both cell types. Macrophages interiorized complexes formed in a wide range of HRP/anti-HRP ratios, while FDC's associated with complexes formed in HRP excess only. Quantitative studies with [12SI]HRP-anti-HRP demonstrated that 20% of the splenic load of HRP associated with FDC's. Complexes formed with an F(ab')~ anti-HRP were distributed primarily in macrophages. When the levels of the third component of serum complement were depleted by prior treatment with cobra venom factor, uptake of complexes by macrophages was reduced some 50% whereas association with FDC's was abolished.The fact that antigen excess complexes are retained extracellularly strengthens the idea that they are immunogenic. Finally, the association of complexes with FDC's seems to retard the entry of antigen into the GC proper.J. CELL BIOLOGY 9 The Rockefeller University Press 9 0021-9525/78

show abstract

“…Several decades ago, it was established that deposition of immune complexes on FDCs was strongly dependent on complement [5][6][7] and the Fc portion of antibodies [7,8]. The complement receptors 1 (CD35) and -2 (CD21) were found to be highly expressed by FDCs [2].…”

Section: Introductionmentioning

confidence: 99%

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

Allen

Cyster

2008

Seminars in Immunology

364

408

View full text Add to dashboard Cite

Follicular dendritic cells (FDCs) were identified decades ago by their ability to retain immune complexes and more recent findings indicate that they are a source of B cell attractants and trophic factors. New imaging studies have shown that B cells closely associate with their dendritic processes during migration. Here we will review the properties of these specialized follicular stromal cells and provide an update on the requirements for their maturation into phenotypically distinct cells within germinal center light and dark zones. We will then discuss current understanding of how they help support the B cell immune response.

show abstract

DISTRIBUTION OF ¹²⁵I‐IMMUNOGLOBULINS, IgG SUBUNITS AND ANTIGEN‐ANTIBODY COMPLEXES IN RAT LYMPH NODES

Cited by 29 publications

References 0 publications

Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to Macrophages

Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to Macrophages

Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells.

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

Contact Info

Product

Resources

About

DISTRIBUTION OF 125I‐IMMUNOGLOBULINS, IgG SUBUNITS AND ANTIGEN‐ANTIBODY COMPLEXES IN RAT LYMPH NODES

Cited by 29 publications

References 0 publications

Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to Macrophages

Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to Macrophages

Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells.

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

Contact Info

Product

Resources

About

DISTRIBUTION OF ¹²⁵I‐IMMUNOGLOBULINS, IgG SUBUNITS AND ANTIGEN‐ANTIBODY COMPLEXES IN RAT LYMPH NODES