Distribution of the CCR5 Gene 32-basepair Deletion in 11 Chinese Populations

Zhang, Chunyu; Fu, Songbin; Xue, Yadong; Wang, Qi; Huang, Xiaolun; Wang, Baiqiu; Liu, An; Ma, Linlin; Ye, Yu; Shi, Rong-qian; Lv, Fuqu; Shi, Zhongcheng; Cheng, Wenhong; Ai, Qionghua; Xu, Feifei; Huang, Chengbin; Chen, Baibin; Kang, Xianghua; Sun, Yuhang; Zhang, Guiyin; Li, Pu

doi:10.1127/anthranz/60/2002/267

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…Our previous studies regarding the polymorphism of CCR5 and SDF1, the other two main AIDS‐related genes, indicated that the CCR5‐Δ32 and SDF1‐3′A allele frequencies were 0.0112 ( n = 715) and 0.2389 ( n = 576), respectively (Zhang et al. , 2002).…”

Section: Resultsmentioning

confidence: 99%

CCR2 allele polymorphisms in 15 Chinese ethnic populations

Zhang

et al. 2006

Int J Immunogenetics

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Chemokine receptor-2 (CCR2) is a co-receptor for the entry of human immunodeficiency virus-1 (HIV-1) into the target cells. A mutation in CCR2 (CCR2-64I) exhibited a protective effect to delay the progression of acquired immunodeficiency syndrome (AIDS). To study the mutant frequency and polymorphism of CCR2 in Chinese populations, 1082 individuals from 15 Chinese populations distributing widely from north to south were collected. The genotypes of CCR2-64I were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with the digestion of restriction endonuclease FokI. Of the 1082 individuals, 352 (32.53%) were carriers of CCR2-64I allele, 257 of whom (23.75%) were heterozygotes (CCR2-64V/I), whereas 95 (8.78%) were homozygotes (CCR2-64V/V). The frequency of the CCR2-64I allele in those tested individuals was 20.66%. This prevalence of CCR2-64I was higher than what was known for American and European populations. Moreover, the frequencies of CCR2-64I were generally higher in northern China than they were in southern China, and the frequencies had significant variance in 15 populations of China (chi2 = 27.135, P = 0.018).

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Section: Resultsmentioning

confidence: 99%

CCR2 allele polymorphisms in 15 Chinese ethnic populations

Zhang

et al. 2006

Int J Immunogenetics

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“…Globally, the distribution of the CCR5Δ32 allele varies widely with 21.7% in North American Caucasians, 20.93% in Ashkenazi Jews, 6.9% in Hispanics, 5.8% in African-Americans, 5.3% in Colombia, 2% in North Africa, and 0.6% in Asian-Americans, (Lucotte and Smets, 2003;Su et al, 2000;Zimmerman et al, 1997). Besides, this deletion was completely absent to extremely low among individuals from Venezuela, central and western Africa, Japanese, Filipino, Korean, Chinese, Brazilian, Indians, and African-Americans (De Pinho Lott Carvalhaes et al, 2004;Kaur et al, 2007;Sharda et al, 2008;Su et al, 2000;Wang et al, 2000;Zhang et al, 2002). In Arabic countries, the frequency of the CCR5Δ32 polymorphism is very low in these populations.…”

Section: Discussionmentioning

confidence: 89%

Determination of the CCR5∆32 frequency in Emiratis and Tunisians and the screening of the CCR5 gene for novel alleles in Emiratis

Al-Jaberi

Ben-Salem

Messedi

et al. 2013

Gene

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“…Although both heterozygous and homozygous individuals have slower progression or resistance to HIV infections [2, 3], even homozygous CCR5Δ32 individuals can still be infected by certain HIV strains [4]. Individuals carrying the CCR5Δ32 allele are in general healthy; however, this allele exists in very low frequency in non-European populations, and no homozygous mutant has been identified in Chinese populations [5, 6]. Therefore, it is very difficult to predict the risk of introducing the CCR5Δ32 allele or other CCR5 mutant alleles into a Chinese genetic background.…”

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confidence: 99%

Gene-edited babies: What went wrong and what could go wrong

Wang

Yang

2019

PLoS Biol

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During the second World Summit of Human Gene Editing, Jiankui He presented the gene-editing project that led to the birth of two baby girls with man-made C-C chemokine receptor type 5 ( CCR5 ) mutations. This extremely irresponsible behavior violated the ethical consensus of scientists all over the world. His presentation revealed a troubling lack not only of basic medical ethics but also of the requisite understanding of genetics and gene editing. Here, we review the rationale and design of his experiment along with the presented data, and provide our scientific criticism of this misconduct.

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Distribution of the CCR5 Gene 32-basepair Deletion in 11 Chinese Populations

Cited by 7 publications

References 4 publications

CCR2 allele polymorphisms in 15 Chinese ethnic populations

CCR2 allele polymorphisms in 15 Chinese ethnic populations

Determination of the CCR5∆32 frequency in Emiratis and Tunisians and the screening of the CCR5 gene for novel alleles in Emiratis

Gene-edited babies: What went wrong and what could go wrong

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