Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

Rodríguez-Castelán, Julia; Anaya-Hernández, Arely; Méndez-Tepepa, Maribel; Martı́nez–Gómez, Margarita; Castelán, Francisco; Cuevas-Romero, Estela

doi:10.1080/07435800.2016.1182185

Cited by 22 publications

(14 citation statements)

References 53 publications

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“…The expression of TRα1‐2, TRβ, and TSHR in the distal urethra and the presence of specific TRH bindings sites at sacral level of spinal cord, including the Onuf's nucleus, support that thyroid actions clearly affect the neural circuits involved in the urethral closure of rabbits . In agreement, we have demonstrated herein that hypothyroidism affects urethral pressure, reducing its maximal pressure and increasing over 10‐fold the urethral resistance, among other outcomes.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism impairs somatovisceral reflexes involved in micturition of female rabbits

Sánchez-García

López-Juárez

Rodríguez-Castelán

et al. 2018

Neurourology and Urodynamics

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Section: Discussionmentioning

confidence: 99%

Hypothyroidism impairs somatovisceral reflexes involved in micturition of female rabbits

Sánchez-García

López-Juárez

Rodríguez-Castelán

et al. 2018

Neurourology and Urodynamics

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“…Considering that granulose and theca cells of primary, secondary, and tertiary follicles, as well as the stroma of the rabbit, express thyroid hormone receptors (TRs) and TSH receptors (TSHR) [33], a direct effect of thyroid hormones and TSH on this tissue could be assumed. In contrast to those studies in humans and animals in which hypothyroidism promotes the formation of cystic follicles [34, 35], we did not find more cystic follicles in hypothyroid rabbits.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits

Rodríguez-Castelán

Méndez-Tepepa

Carrillo-Portillo

et al. 2017

BioMed Research International

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Ovarian failure is related to dyslipidemias and inflammation, as well as to hypertrophy and dysfunction of the visceral adipose tissue (VAT). Although hypothyroidism has been associated with obesity, dyslipidemias, and inflammation in humans and animals, its influence on the characteristics of ovarian follicles in adulthood is scarcely known. Control and hypothyroid rabbits were used to analyze the ovarian follicles, expression of aromatase in the ovary, serum concentration of lipids, leptin, and uric acid, size of adipocytes, and infiltration of macrophages in the periovarian VAT. Hypothyroidism did not affect the percentage of functional or atretic follicles. However, it reduced the size of primary, secondary, and tertiary follicles considered as large and the expression of aromatase in the ovary. This effect was associated with high serum concentrations of total cholesterol and low-density lipoprotein cholesterol (LDL-C). In addition, hypothyroidism induced hypertrophy of adipocytes and a major infiltration of CD68+ macrophages into the periovarian VAT. Our results suggest that the reduced size of ovarian follicles promoted by hypothyroidism could be associated with dyslipidemias, hypertrophy, and inflammation of the periovarian VAT. Present findings may be useful to understand the influence of hypothyroidism in the ovary function in adulthood.

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“…The prostate is an accessory gland of the reproductive system, whose function is to produce an alkaline secretion that promotes the nutrition and survival of spermatozoa . Several studies have reported the presence of a prostate in women and female rodents . In gerbils, the female prostate presents structural homology with the ventral male prostate, making this a valuable model for comparative prostate studies…”

Section: Introductionmentioning

confidence: 99%

Short‐term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

Campos

Silva

Lima

et al. 2019

Int J Experimental Path

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Summary Chrysin (5,7‐dihydroxyflavone) is a bioactive compound found in different fruits, vegetables, honey and propolis. This flavone has been suggested for the treatment of reproductive dysfunction, mainly because of its antioxidant and hormonal properties. However, the effects of this polyphenol on the prostate are still poorly understood. The purpose of this study was to evaluate the effects of short‐term chrysin exposure on the ventral male and female prostates of adult gerbils. To evaluate the androgenic potential of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin (50 mg/kg/day, orally) or testosterone cypionate (1 mg/kg/week, subcutaneously) for 3, 7 and 21 days. Prostates were dissected for morphological, stereological and immunohistochemical analyses. Serum levels of testosterone and 17β‐estradiol were measured by ELISA. Serum testosterone levels were not increased by chrysin supplementation in males or females. However, only females treated with chrysin for 21 days showed an increase in estradiol levels. Increased androgen receptor immunoreactivity, higher proliferation rates and glandular hyperplasia were observed in male and female prostates for all chrysin treatment times. Additionally, increased oestrogen receptor alpha immunoreactivity was observed in all chrysin‐treated females. Although chrysin and testosterone promoted similar morphological changes in the gerbil prostate, chrysin supplementation was less deleterious to prostate health, since it resulted in lower incidence of hyperplasia and an absence of neoplastic foci.

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Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits

Abstract: The wide presence of TRs and TSHR in female reproductive organs suggests varied effects of thyroid hormones and thyrotropin in reproduction.

Cited by 22 publications

References 53 publications

Hypothyroidism impairs somatovisceral reflexes involved in micturition of female rabbits

Hypothyroidism impairs somatovisceral reflexes involved in micturition of female rabbits

Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits

Short‐term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

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