Distribution of TRPC4 in developing and adult murine brain

Zechel, Sabrina; Werner, Sandra; Halbach, Oliver von Bohlen und

doi:10.1007/s00441-007-0388-4

Cited by 36 publications

(19 citation statements)

References 27 publications

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“…Three of the other "repressors" that we identified are more usually associated with neurons: TRPC4 is a potential cation channel expressed in the developing (murine) brain (44), and Dscaml1 may, based on its expression pattern, be involved in formation and maintenance of neural networks (1). Nlgn3 is a neuron-specific adhesion molecule, mutations in which are associated with autism-spectrum disorders and mental retardation (7), diseases which have also been associated with abnormal myelination (10).…”

Section: Discussionmentioning

confidence: 99%

Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits

Gobert

Joubert

Curchod

et al. 2009

Molecular and Cellular Biology

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Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a critical role in oligodendrocyte differentiation, we performed time-dependent, genomewide gene expression studies of mouse Oli-neu cells as they differentiate into process-forming and myelin basic protein-producing cells, following treatment with three different agents. Our data indicate that different inducers activate distinct pathways that ultimately converge into the completely differentiated state, where regulated gene sets overlap maximally. In order to also gain insight into the functional role of genes that are regulated in this process, we silenced 88 of these genes using small interfering RNA and identified multiple repressors of spontaneous differentiation of Oli-neu, most of which were confirmed in rat primary oligodendrocyte precursors cells. Among these repressors were CNP, a well-known myelin constituent, and three phosphatases, each known to negatively control mitogen-activated protein kinase cascades. We show that a novel inhibitor for one of the identified genes, dual-specificity phosphatase DUSP10/MKP5, was also capable of inducing oligodendrocyte differentiation in primary oligodendrocyte precursors. Oligodendrocytic differentiation feedback loops may therefore yield pharmacological targets to treat disease related to dysfunctional myelin deposition.

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Section: Discussionmentioning

confidence: 99%

Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits

Gobert

Joubert

Curchod

et al. 2009

Molecular and Cellular Biology

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“…TRPC3 expression is most prominent in the cerebellum [26,28,29]. TRPC4 is highly expressed in the lateral septum and the CA1 region of the hippocampus [30,31,32,33]. TRPC5 is highly expressed in the CA1-CA3 region of the hippocampus and the amygdala [34,35].…”

Section: Expression Structure and Pharmacology Of Trpc Channelsmentioning

confidence: 99%

The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

Zheng

Phelan

2014

Cells

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Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an increase in intracellular free Ca2+ concentration. Thus, activation of TRPC channels could be a common downstream event of many signaling pathways that contribute to seizure and excitotoxicity, such as N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ influx, or metabotropic glutamate receptor activation. Recent studies with genetic ablation of various TRPC family members have demonstrated that TRPC channels, in particular heteromeric TRPC1/4 channels and homomeric TRPC5 channels, play a critical role in both pilocarpine-induced acute seizures and neuronal cell death. However, exact underlying mechanisms remain to be fully elucidated, and selective TRPC modulators and antibodies with better specificity are urgently needed for future research.

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“…In contrast to peripheral olfactory sensory neurons, far less is known about TRP channels in the rodent OB. mRNAs for several members of the TRPC family have been detected in OB tissue and unidentified OB neurons [16,17,20,22,35]. Cation currents with TRP-like electrophysiological and pharmacological properties have also been reported in several OB neuron types [7,24,25].…”

Section: Introductionmentioning

confidence: 99%

Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb

Dong

Davis

Ding

et al. 2012

Neuroscience Letters

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Transient receptor potential (TRP) channels are a large family of cation channels. The 28 TRP channel subtypes in rodent are divided into 6 subfamilies: TRPC1-7, TRPV1-6, TRPM1-8, TRPP2/3/5, TRPML1-3 and TRPA1. TRP channels are involved in peripheral olfactory transduction. Several TRPC channels are expressed in unidentified neurons in the main olfactory bulb (OB), but the expression of most TRP channels in the OB has not been investigated. The present study employed RT-PCR as an initial survey of the expression of channel mRNAs in the mouse OB and in 3 cell types: external tufted, mitral and granule cells. All TRP channel mRNAs except TRPV5 were detected in OB tissue. Single cell RT-PCR revealed that external tufted, mitral and granule cell populations expressed in aggregate 14 TRP channel mRNAs encompassing members of all 6 subfamilies. These different OB neuron populations expressed 7 to 12 channel mRNAs. Common channel expression was more similar among external tufted and mitral cells than among these cells and granule cells. These results indicate that a large number of TRP channel subtypes are expressed in OB neurons, providing the molecular bases for these channels to regulate OB neuron activity and central olfactory processing.

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Distribution of TRPC4 in developing and adult murine brain

Cited by 36 publications

References 27 publications

Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits

Convergent Functional Genomics of Oligodendrocyte Differentiation Identifies Multiple Autoinhibitory Signaling Circuits

The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb

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