Distribution of Type I, III, IV and V Collagen in Normal and Atherosclerotic Human Arterial Wall: Immunomorphological Characteristics

Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies.

“…In this respect our findings corroborate previous immunofluorescence studies. 12 " 15 Mayne 10 and Shekhonin et al 13 have assumed that type I and III collagens, which are the most important collagens involved in platelet aggregation, play a critical role in the formation and progress of the disease. The increase of the type I to type III collagen ratio that has been detected biochemically 29 -31 is closely associated with intimal sclerosis and lesion progression.…”

“…This feature was also described in previous immunofluorescence studies. 13 -15 ' 50 Ross et al 51 showed that multilayered basement membranes were formed around the flat smooth muscle cells in the atheromatous plaque, especially in the fibrous cap. Therefore, the present findings on the distribution of type IV collagen seem to suggest a relation between the morphological change of smooth muscle cells and the formation of basement membranes.…”

Prevention and regression of hypertension: role of renal microvascular protection

“…47 In humans, types I and III have been detected in the intima media and adventitia. 48 In the large arteries, elastin can comprise up to 50% of its dry weight, 49 however, in the resistance arteries, elastin is much less abundant and is localized mainly in the internal and external elastic lamina. The fibrous proteins collagen and elastin are embedded in a gel-like ground substance composed of proteoglycans/glycosaminoglycans.…”

Delamination properties of the human thoracic arterial wall with early stage of atherosclerosis lesions

“…The intimal layer is built mostly of connective tissue (Shekhonin et al, 1985), and in young and healthy people it is not involved in the transfer of mechanical stress. In the physiological range of blood pressure.…”

“…The collagen fibres in this layer are arranged circumferentially (Schriefl et al, 2012). In the case of arterial hypertension, the process of transfer of stress also involves the adventitia (collagen fibres) (Shekhonin et al, 1985), which protects the vessel against overstretching and rupture (Holzapfel 2008;Schulze-Bauer et al, 2001). In the adventitia, collagen fibres are dispersed, and only individual fibres are arranged circumferentially (Schriefl et al, 2012).…”