Distribution of urinary selenium and arsenic among pregnant women exposed to arsenic in drinking water

Christian, W; Hopenhayn, Claudia; Centeno, José A.; Todorov, Todor I.

doi:10.1016/j.envres.2005.03.009

Cited by 65 publications

(40 citation statements)

References 30 publications

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“…All of the Andean women had whole-blood selenium concentrations (range: 139-222 mg/L) well above the average concentration (95 mg/L) in seleniumadequate areas (48). Total U-Se concentrations were in the same range as those previously published for women in northern Chile (49). The selenium concentrations in the Bangladeshi cohort were much lower and were similar to those reported for women in India (50).…”

Section: Discussionsupporting

confidence: 74%

Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene

Kuehnelt

Engström

Skröder

et al. 2015

The American Journal of Clinical Nutrition

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Background: Selenium is an essential element, but its metabolism in humans is not well characterized. A few small studies indicate that the trimethylselenonium ion (TMSe) is a common selenium metabolite in humans.Objective: This study aimed to elucidate the human metabolism of selenium to TMSe. Design: Study individuals constituted subsamples of 2 cohorts: 1) pregnant women (n = 228) and their 5-y-old children (n = 205) in rural Bangladesh with poor selenium status [median urinary selenium (U-Se): 6.4 mg/L in mothers, 14 mg/L in children] and 2) women in the Argentinian Andes (n = 83) with adequate selenium status (median U-Se: 24 mg/L). Total U-Se and blood selenium were measured by inductively coupled plasma mass spectrometry (ICPMS), and urinary concentrations of TMSe were measured by high-performance liquid chromatography/vapor generation/ICPMS. A genomewide association study (GWAS) was performed for 1,629,299 (after filtration) single nucleotide polymorphisms (SNPs) in the Bangladeshi women (n = 72) by using Illumina Omni5M, and results were validated by using real-time polymerase chain reaction. Results: TMSe "producers" were prevalent (approximately onethird) among the Bangladeshi women and their children, in whom TMSe constituted w10-70% of U-Se, whereas "nonproducers" had, on average, 0.59% TMSe. The TMSe-producing women had, on average, 2-mg U-Se/L higher concentrations than did the nonproducers. In contrast, only 3 of the 83 Andean women were TMSe producers (6-15% TMSe in the urine); the average percentage among the nonproducers was 0.35%. Comparison of the percentage of urinary TMSe in mothers and children indicated a strong genetic influence. The GWAS identified 3 SNPs in the indolethylamine Nmethyltransferase gene (INMT) that were strongly associated with percentage of TMSe (P , 0.001, false-discovery rate corrected) in both cohorts. Conclusions: There are remarkable population and individual variations in the formation of TMSe, which could largely be explained by SNPs in INMT. The TMSe-producing women had higher U-Se concentrations than did nonproducers, but further elucidation of the metabolic pathways of selenium is essential for the understanding of its role in human health. The MINIMat trial was registered at isrctn.org as ISRCTN16581394.Am J Clin Nutr 2015;102:1406-15.

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Section: Discussionsupporting

confidence: 74%

Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene

Kuehnelt

Engström

Skröder

et al. 2015

The American Journal of Clinical Nutrition

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“…Selenium is the key element of glutathione peroxidase and other selenium proteins, and is essential for counteracting reactive oxygen species, protecting from oxidative stress, and regulating the redox status in cells [2]. This essential mineral also appears to correlate with stimulation of metabolic detoxification and excretion of arsenic [27,28]. Thus, selenium is expected to reduce the toxicity and cancer risk of arsenic [29,30], although high body burden of selenium is toxic.…”

Section: Discussionmentioning

confidence: 99%

Metallomics study using hair mineral analysis and multiple logistic regression analysis: relationship between cancer and minerals

Yasuda¹,

Yoshida²,

Segawa³

et al. 2009

Environ Health Prev Med

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Objectives The objective of this metallomics study is to investigate comprehensively some relationships between cancer risk and minerals, including essential and toxic metals. Methods Twenty-four minerals including essential and toxic metals in scalp hair samples from 124 solid-cancer patients and 86 control subjects were measured with inductively coupled plasma mass spectrometry (ICP-MS), and the association of cancer with minerals was statistically analyzed with multiple logistic regression analysis. Results Multiple logistic regression analysis demonstrated that several minerals are significantly correlated to cancer, positively or inversely. The most cancer-correlated mineral was iodine (I) with the highest correlation coefficient of r = 0.301, followed by arsenic (As; r = 0.267), zinc (Zn; r = 0.261), and sodium (Na; r = 0.190), with p \ 0.01 for each case. In contrast, selenium (Se) was inversely correlated to cancer (r = -0.161, p \ 0.05), followed by vanadium (V) (r = -0.128). Multiple linear regression value was highly significantly correlated with probability of cancer (R 2 = 0.437, p \ 0.0001), and the area under the receiver-operating characteristic (ROC) curve was calculated to be 0.918. In addition, using contingency table analysis and the chi-square test, the precision of discrimination for cancer was estimated to be 0.871 (chi-square = 99.1, p \ 0.0001). Conclusions These findings suggest that some minerals such as arsenic, selenium, and probably iodine, zinc, sodium, and vanadium contribute to regulation of cancer and also that metallomics study using multiple logistic regression analysis is a useful tool for estimating cancer risk.

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“…Thus, As/Cd S Humans More pronounced renal toxicity than exposure to each of the agents alone [198] S Rats Induce lipid peroxidation, glutathione and metallothionein, as well as the redistribution of essential elements [199] As/Zn A Rats Zn counteracts As-induced abnormal blood lipids [96] A Rats Zn prevents arsenic-induced tissue oxidative stress [200] As/P A Human cells As perturbs phospholipid bilayer structures, modifying their thermotropic behaviour [201] A Bacterial systems Bacterium that can grow with As instead of P [101] A Zn decreases Cu concentrations in kidney and liver [232] A Rats Zn competes with Cu [233] A Humans and rats Zn influences Cu-induced lipid peroxidation [234] Cu/Fe A Arthropods and molluscs Fe substitutes Cu in some enzyme families [100] selenium deficiency can decrease the excretion of inorganic and organic arsenic in animal models [108], and may induce the accumulation of As in mice liver [109]. On the other hand, selenium sufficiency increases the excretion of arsenic in pregnant women [110] and mice [108]. In relation to the mechanism of the As/Se interaction, X-rays were used to identify seleno-bis(S-glutathionyl) arsinium ion [(GS) 2 AsSe − ] in the bile of rabbits injected with aqueous selenite and arsenite solutions in a study performed in the year 2000.…”

Section: As/sementioning

confidence: 99%

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

et al. 2012

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The fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number of them that provide very good performance. However, biological systems are exposed to a complex environment in which species of elements can interact in a synergistic/antagonistic fashion. Thus, the metabolism of trace elements cannot be considered in isolation. On the other hand, biological systems are dynamic, so it is necessary to study the trafficking of species of elements between organs, tissues or cell compartments in order to decipher the biochemical processes of the interactions in which they are involved. Although the application of liquid chromatography-inductively coupled plasma-based "metallomics" methods in combination with organic mass spectrometry can provide much-needed insight, new analytical strategies are required to really understand the role of species of elements in biological systems and the mechanisms of their interactions. In the present paper, the interactions of the most widely studied elements in this context (Se, Hg and As) are discussed, as well as other important interactions between different elements.

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Distribution of urinary selenium and arsenic among pregnant women exposed to arsenic in drinking water

Cited by 65 publications

References 30 publications

Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene

Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene

Metallomics study using hair mineral analysis and multiple logistic regression analysis: relationship between cancer and minerals

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

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