Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset

Schorscher-Petcu, Ara; Dupré, Anouk; Tribollet, Eliane

doi:10.1016/j.neulet.2009.06.016

Cited by 87 publications

(94 citation statements)

References 44 publications

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“…3 Rodents, which primarily use olfactory inputs for social recognition and social memory, present as a common feature a high level of OTR expression in the olfactory system, which is the primary modality of social investigation and interaction. Finally, in primates, OTR are found in the nucleus basalis of Meynert and the superior colliculus in the four primate species analyzed so far [marmoset (35), coppery titi monkey (37), rhesus macaque (29), and human (38)]. The presence of OTRs in regions that modulate visual attention supports the hypothesis that, in primates, OTRs act at the most relevant sensory modalities to regulate social approach and behavior (29) (Figure 4).…”

Section: Ot Receptor Trajectories In Evolutionsupporting

confidence: 61%

“…As can be seen, the spatial pattern of OTR expression greatly impacts on specific behaviors, as was first shown in the pioneering work (28) in four classes of vertebrates. Autoradiography, in situ hybridization, and immunohistochemistry studies presented in the literature are schematically summarized here; references include for teleosts (88); for songbirds (32,33); for rodents (15,89); and for primates (29,35,37,38). Areas of the mesolimbic social decision making network include: nucleus accumbens (NAcc); ventral pallidum (VP); lateral septum (LS); preoptic area (POA); ventromedial nucleus of hypothalamus (VMH); basolateral amygdala (blAMY); medial amygdala, (meAMY); bed nucleus of the stria terminalis (BNST); anterior hypothalamus (AH); hippocampus (HIP); ventral tegmental area (VTA); periaqueductal gray (PAG); and striatum (Str).…”

Section: Ot Receptor Trajectories In Evolutionmentioning

confidence: 99%

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Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

Grinevich

Knobloch‐Bollmann

Eliava

et al. 2016

Biological Psychiatry

248

185

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Oxytocin (OT) is a neuropeptide, which can be seen to be one of the molecules of the decade due to its profound prosocial effects in nonvertebrate and vertebrate species, including humans. Although OT can be detected in various physiological fluids (blood, saliva, urine, cerebrospinal fluid) and brain tissue, it is unclear whether peripheral and central OT releases match and synergize. Moreover, the pathways of OT delivery to brain regions involved in specific behaviors are far from clear. Here, we discuss the evolutionarily and ontogenetically determined pathways of OT delivery and OT signaling, which orchestrate activity of the mesolimbic social decision-making network. Furthermore, we speculate that both the alteration in OT delivery and OT receptor expression may cause behavioral abnormalities in patients afflicted with psychosocial diseases.

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Section: Ot Receptor Trajectories In Evolutionsupporting

confidence: 61%

Section: Ot Receptor Trajectories In Evolutionmentioning

confidence: 99%

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

Grinevich

Knobloch‐Bollmann

Eliava

et al. 2016

Biological Psychiatry

248

185

View full text Add to dashboard Cite

show abstract

“…AVP receptor distributions in monogamous marmosets (91,92) and titi monkeys (93), as well as in polygnous rhesus macaques (94), parallel those observed in monogamous and promiscuous voles, respectively, confirming that this reward pathway functions similarly in primates. Although receptor distributions such as those now available for some monkey species are not yet available for humans, there are marked parallels in other related cerebral phenomena revealed by functional magnetic resonance imaging (see also below).…”

Section: Owen Lovejoysupporting

confidence: 56%

Reexamining Human Origins in Light of Ardipithecus ramidus

Lovejoy

2009

Science

290

205

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Referential models based on extant African apes have dominated reconstructions of early human evolution since Darwin’s time. These models visualize fundamental human behaviors as intensifications of behaviors observed in living chimpanzees and/or gorillas (for instance, upright feeding, male dominance displays, tool use, culture, hunting, and warfare). Ardipithecus essentially falsifies such models, because extant apes are highly derived relative to our last common ancestors. Moreover, uniquely derived hominid characters, especially those of locomotion and canine reduction, appear to have emerged shortly after the hominid/chimpanzee divergence. Hence, Ardipithecus provides a new window through which to view our clade’s earliest evolution and its ecological context. Early hominids and extant apes are remarkably divergent in many cardinal characters. We can no longer rely on homologies with African apes for accounts of our origins and must turn instead to general evolutionary theory. A proposed adaptive suite for the emergence of Ardipithecus from the last common ancestor that we shared with chimpanzees accounts for these principal ape/human differences, as well as the marked demographic success and cognitive efflorescence of later Plio-Pleistocene hominids.

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“…As the C allele was found to be associated with lower CD38 expression in lymphoblastoid cells in ASD patients (Lerer et al, 2010) and lower CD38 expression to result in reduced OT secretion (Jin et al, 2007) it is not clear how reduced OT secretion results in higher fusiform activation. So far, in humans and primates there is no evidence that the fusiform gyrus could be a potential direct target of OT in terms of existing OT receptors (Loup et al, 1991;Schorscher-Petcu et al, 2009). Therefore, it could be speculated that OT probably affects fusiform activation via so far unknown mechanisms, perhaps via interacting with other neurotransmitter systems like eg the dopamine system.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Common Variant in the CD38 Gene on Social Processing in an Oxytocin Challenge Study: Possible Links to Autism

Sauer

Montag

Wörner

et al. 2012

Neuropsychopharmacol

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The intranasal application of oxytocin (OT) has been shown to influence behavioral and neural correlates of social processing. These effects are probably mediated by genetic variations within the OT system. One potential candidate could be the CD38 gene, which codes for a transmembrane protein engaged in OT secretion processes. A common variation in this gene (rs3796863) was recently found to be associated with autism spectrum disorders (ASD). Using an imaging genetics approach, we studied differential effects of an intranasal OT application on neural processing of social stimuli in 55 healthy young men depending on their CD38 gene variant in a double-blind placebo-controlled crossover design. Genotype had a significant influence on both behavioral and neuronal measures of social processing. Homozygotic risk allele carriers showed slower reaction times (RT) and higher activation of left fusiform gyrus during visual processing of social stimuli. Under OT activation differences between genotypes were more evident (though not statistically significantly increased) and RT were accelerated in homozygotic risk allele carriers. According to our data, rs3796863 mainly influences fusiform gyrus activation, an area which has been widely discussed in ASD research. OT seems to modulate this effect by enhancing activation differences between allele groups, which suggests an interaction between genetic makeup and OT availability on fusiform gyrus activation. These results support recent approaches to apply OT as a pharmacological treatment of ASD symptoms.

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Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset

Cited by 87 publications

References 44 publications

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

Reexamining Human Origins in Light of Ardipithecus ramidus

Effects of a Common Variant in the CD38 Gene on Social Processing in an Oxytocin Challenge Study: Possible Links to Autism

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