Distribution of Ventilation in Lung Transplant Recipients: Evaluation by Dynamic 3He-MRI With Lung Motion Correction

Gast, Klaus; Puderbach, Michael; Rodríguez, Ignacio; Eberle, Balthasar; Markstaller, Klaus; Knitz, Frank; Schmiedeskamp, Joerg; Weiler, Norbert; Schreiber, Laura M.; Mayer, E; Thelen, M.; Kauczor, Hans‐Ulrich

doi:10.1097/01.rli.0000065422.24911.74

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…The observed ventilation defects vary from reduced inflow to air trapping as observed in the later phases of the respiratory cycle, which are more markedly visualized in subjects with CT-proven centrilobular emphysema (94)(95)(96).…”

Section: Hyperpolarized Noble Gas Imagingmentioning

confidence: 95%

Imaging phenotypes of chronic obstructive pulmonary disease

Ley‐Zaporozhan¹,

Beek²

2010

Magnetic Resonance Imaging

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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways and/or the parenchyma with different severity during the course of the disease. These different aspects of COPD can be addressed by imaging using a combination of morphological and functional techniques. Computed tomography (CT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about ventilation and perfusion, mainly provided by magnetic resonance imaging (MRI). The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization, and dedicated therapy monitoring of the disease.

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Section: Hyperpolarized Noble Gas Imagingmentioning

confidence: 95%

Imaging phenotypes of chronic obstructive pulmonary disease

Ley‐Zaporozhan¹,

Beek²

2010

Magnetic Resonance Imaging

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“…The extent of ventilation defects in lung transplant recipients correlated well with observed declines in pulmonary function in patients with known or suspected allograft rejection [24] and with the clinical grade of BOS [22]. In dynamic ventilation 3 He-MRI, differences between normal lung grafts and native diseased lungs were detected, whereas chronic graft rejection could not be detected by the current state of that technique [25]; however, improvements in sequence design and measurement parameters are ongoing [17,26].…”

Section: Discussionmentioning

confidence: 92%

3He-MRI in follow-up of lung transplant recipients

Gast¹,

Zaporozhan²,

Ley³

et al. 2003

Eur Radiol

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The aim of this study was to evaluate the possible contribution of (3)He-MRI to detect obliterative bronchiolitis (OB) in the follow-up of lung transplant recipients. Nine single- and double-lung transplanted patients were studied by an initial and a follow-up (3)He-MRI study. Images were evaluated subjectively by estimation of ventilation defect area and quantitatively by individually adapted threshold segmentation and subsequent calculation of ventilated lung volume. Bronchiolitis obliterans syndrome (BOS) was diagnosed using pulmonary function tests. At (3)He-MRI, OB was suspected if ventilated lung volume had decreased by 10% or more at the follow-up MRI study compared with the initial study. General accordance between pulmonary function testing and (3)He-MRI was good, although subjective evaluation of (3)He-MRI underestimated improvement in ventilation as obtained by pulmonary function tests. The (3)He-MRI indicated OB in 6 cases. According to pulmonary function tests, BOS was diagnosed in 5 cases. All diagnoses of BOS were also detected by (3)He-MRI. In 2 of these 5 cases, (3)He-MRI indicated OB earlier than pulmonary function tests. The results support the hypothesis that (3)He-MRI may be sensitive for early detection of OB and emphasize the need for larger prospective follow-up studies.

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“…3 Helium MRI with high temporal resolution shows the dynamic distribution of ventilation during continuous breathing after inhalation of a single breath of 3 Helium gas being capable to demonstrate airflow abnormalities [63,64]. Homogeneous and fast distribution is regarded as normal, whereas COPD/emphysema patients show irregular and delayed patterns with redistribution and airtrapping [64][65][66].…”

Section: Mrimentioning

confidence: 98%

Morphological and functional imaging in COPD with CT and MRI: present and future

2007

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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways (i.e. chronic bronchitis, airway collapse), the parenchyma (i.e. hyperinflation, air trapping and emphysematous destruction) as well as the vasculature (i.e. hypoxic vasoconstriction, rarefication and pulmonary arterial hypertension) with different severity during the course of the disease. These different aspects of COPD can be best addressed by imaging using a combination of morphological and functional techniques. Three-dimensional high-resolution computed tomography (3D-HRCT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about perfusion, regional lung mechanics, and ventilation mainly provided by MRI. The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization and dedicated therapy monitoring of COPD as presented in this review.

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Distribution of Ventilation in Lung Transplant Recipients: Evaluation by Dynamic 3He-MRI With Lung Motion Correction

Cited by 17 publications

References 18 publications

Imaging phenotypes of chronic obstructive pulmonary disease

Imaging phenotypes of chronic obstructive pulmonary disease

3He-MRI in follow-up of lung transplant recipients

Morphological and functional imaging in COPD with CT and MRI: present and future

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