Distribution Pattern of Basal Cells Detected by Cytokeratin 34 Beta E12 in Primary Prostatic Duct Adenocarcinoma

Samaratunga, Hemamali; Singh, Mahendra

doi:10.1097/00000478-199704000-00009

Cited by 43 publications

(25 citation statements)

References 14 publications

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“…Obvious cases of ductal adenocarcinoma can have residual basal cells and so high molecular weight cytokeratin may not be of value. 20 Generally, if the ductal structures are confluent or back-to-back, and are expanded, I will make a diagnosis of cancer even in needle biopsy specimens.…”

Section: Prostatic Ductal Adenocarcinomamentioning

confidence: 99%

Unusual subtypes of prostate cancer

2004

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The vast majority of prostatic tumors developing in adult males are adenocarcinomas. For the most part, variations in histology have not received specific designations and, from a practical approach, have had any specific prognostic implications handled through application of the Gleason grading system. Nonetheless, some of the adenocarcinoma variants have specific clinical features and differential diagnoses. Furthermore, there has been some controversy regarding the appropriate application of the Gleason grading scheme in these tumors. In addition, there are carcinomas that are in fact not adenocarcinomas and that should be kept as distinct entities. In this paper, the histologic variants of adenocarcinoma are reviewed with emphasis on clinicopathologic features and the clinical relevance of these subtypes. Other carcinomas that occur in the prostate gland are also discussed again with a focus on the clinicopathologic characteristics.

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Section: Prostatic Ductal Adenocarcinomamentioning

confidence: 99%

Unusual subtypes of prostate cancer

2004

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“…Limited scale data do exist on comparative protein expression in ductal versus acinar adenocarcinoma, 7,12,[14][15][16][17][18][19][20][21][22][23][24][25] but comparative global gene expression profiling has not been performed. The aim of this study was to examine the gene expression profiles of ductal versus acinar adenocarcinoma to assess the molecular relatedness of ductal and acinar adenocarcinomas and to identify potential molecular differences that may explain the different histopathological features and disparate clinical behavior of ductal adenocarcinoma of the prostate.…”

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confidence: 99%

Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate

et al. 2009

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Ductal adenocarcinoma is an uncommon variant of prostatic adenocarcinoma with a generally more aggressive clinical course than usual acinar adenocarcinoma. However, the molecular distinction between ductal and acinar adenocarcinomas is not well characterized. The aim of this investigation was to evaluate the relatedness of ductal versus acinar prostatic adenocarcinoma by comparative gene expression profiling. Archived, deidentified, snap frozen tumor tissue from 5 ductal adenocarcinomas, 3 mixed ductal-acinar adenocarcinomas, and 11 acinar adenocarcinomas cases were analyzed. All cases of acinar and ductal adenocarcinomas were matched by Gleason grade. RNA from whole tissue sections of the 5 ductal and 11 acinar adenocarcinomas cases were subjected to gene expression profiling on Affymetrix U133Plus2 microarrays. Independently, lasercapture microdissection was also performed on the three mixed ductal-acinar cases and five pure acinar cases to isolate homogeneous populations of ductal and acinar carcinoma cells from the same tumor. Seven of these laser-capture microdissected samples (three ductal and four acinar cell populations) were similarly analyzed on U133Plus2 arrays. Analysis of data from whole sections of ductal and acinar carcinomas identified only 25 gene transcripts whose expression was significantly and at least two-fold different between ductal and acinar adenocarcinomas. A similar analysis of microdissected cell populations identified 10 transcripts, including the prolactin receptor, with more significant differences in expression of 5-to 27-fold between ductal and acinar adenocarcinomas cells. Overexpression of prolactin receptor protein in ductal versus acinar adenocarcinoma was confirmed by immunohistochemistry in an independent set of tumors. We conclude that ductal and acinar adenocarcinomas of the prostate are strikingly similar at the level of gene expression. However, several of the genes identified in this study, including the prolactin receptor, represent targets for further investigations on the molecular basis for histomorphological and clinical behavioral differences between acinar and ductal adenocarcinomas.

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“…Papillary ductal adenocarcinoma of the prostate develops within large ducts and commences by intraductal spread. In these cases, residual basal cells can be detected immunohistochemically [55]. Similar problems may occur in development and intraductal spread of cribriform carcinomas.…”

Section: Ductal and Intraductal Prostatic Carcinomamentioning

confidence: 76%

Differential diagnosis of glandular proliferations in the prostate

Helpap

1998

Virchows Archiv

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A variety of small acinar lesions of the prostate can mimic prostate cancer in punch biopsies and in transurethral resection material. The first part of this review deals with differential diagnostic problems of the central and transition zone, including atypical adenomatous hyperplasia of the prostate, atrophic processes, sclerosing adenosis, basal cell hyperplasia, and low-grade adenocarcinoma. The second part deals with differential diagnostic problems in the peripheral zone: prostatic intraepithelial neoplasia, postatrophic hyperplasia, Cowper's glands, seminal vesicles, and ductal and intraductal carcinoma. Finally, atypical and small acinar proliferations are described. Diagnostic perspectives are discussed. proliferations (ASAP) that cannot be integrated into any of the well-established diagnostic entities [1, 16, 22, 41]. The relevant glandular proliferations of the central, transitional and peripheral zones of the prostate are discussed here with reference to the related carcinomas.

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Distribution Pattern of Basal Cells Detected by Cytokeratin 34 Beta E12 in Primary Prostatic Duct Adenocarcinoma

Cited by 43 publications

References 14 publications

Unusual subtypes of prostate cancer

Unusual subtypes of prostate cancer

Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate

Differential diagnosis of glandular proliferations in the prostate

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