Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development

Gunther, W. C.; Skaftnesmo, Kai-Ove; Arnold, H.; Bjerkvig, Rolf; Terzis, A. J. A.

doi:10.1016/j.acthis.2004.07.009

Cited by 22 publications

(16 citation statements)

References 26 publications

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“…Our unpublished data show that Adamts4 is extremely sparsely expressed during mouse embryonic development, and is therefore unlikely to significantly compensate for loss of Adamts5 . Adamts1 is however, very strongly expressed in an overlapping pattern with ADAMTS5 at several sites, such as in vascular smooth muscle cells of arteries, endocardium, the choroid plexus, dorsal root ganglia, bone and interdigital mesenchyme (Gunther et al, 2005; Kern et al, 2007; Thai and Iruela-Arispe, 2002), suggesting it may degrade versican cooperatively with Adamts5 at these sites. Functions for Adamts1 have been established in the regulation of angiogenesis, fertility, urinary tract development and in regulatory interactions between endocardium and myocardium that are critical for cardiac development (Brown et al, 2006; Kern et al, 2007; Krampert et al, 2005; Mittaz et al, 2005; Mittaz et al, 2004; Shindo et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

McCulloch

Goff

Bhatt

et al. 2009

Gene Expression Patterns

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The secreted metalloprotease ADAMTS5 is implicated in destruction of the cartilage proteoglycan aggrecan in arthritis, but its physiological functions are unknown. Its expression profile during embryogenesis and in adult tissues is therefore of considerable interest. β-galactosidase (β-gal) histochemistry, enabled by a LacZ cassette inserted in the Adamts5 locus, and validated by in situ hybridization with an Adamts5 cRNA probe and ADAMTS5 immunohistochemistry, was used to profile Adamts5 expression during mouse embryogenesis and in adult mouse tissues. Embryonic expression was scarce prior to 11.5 days of gestation (E11.5) and noted only in the floor plate of the developing brain at E9.5. After E 11.5 there was continued expression in brain, especially in the choroid plexus, peripheral nerves, dorsal root ganglia, cranial nerve ganglia, spinal and cranial nerves, and neural plexuses of the gut. In addition to nerves, developing limbs have Adamts5 expression in skeletal muscle (from E13.5), tendons (from E16.5), and inter-digital mesenchyme of the developing autopod (E13.5–15.5). In adult tissues, there is constitutive Adamts5 expression in arterial smooth muscle cells, mesothelium lining the peritoneal, pericardial and pleural cavities, smooth muscle cells in bronchii and pancreatic ducts, glomerular mesangial cells in the kidney, dorsal root ganglia, and in Schwann cells of the peripheral and autonomic nervous system. Expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate. These observations suggest the major contexts in which developmental and physiological roles could be sought for this protease.

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Section: Resultsmentioning

confidence: 99%

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

McCulloch

Goff

Bhatt

et al. 2009

Gene Expression Patterns

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“…An analysis of the tissue distributions showed detectable levels of ADAMTS1 transcripts in the rat developing brain, with a steep down‐regulation at the end of gestation, and much lower levels in the adult (20, 21). Interestingly, the brain regions exhibiting ADAMTS1 and ADAMTS8 expression do not appear to overlap in humans (1).…”

Section: Discussionmentioning

confidence: 98%

The quantification of ADAMTS expression in an animal model of cerebral ischemia using real‐time PCR

Tian

Zhang

Xiao

et al. 2006

Acta Anaesthesiol Scand

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“…TNFSF10 might play an important role in skeletal myoblast differentiation [32]. Rat experiments observed that ADAMTS1 was highly expressed in skeletal muscle [33], and muscular development appeared to rely on ADAMTS1 [34]. Replication studies are needed to validate the associations between the 17 genes and lean body mass detected in this study.…”

Section: Discussionmentioning

confidence: 73%

Multilocus Association Testing of Quantitative Traits Based on Partial Least-Squares Analysis

2011

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Because of combining the genetic information of multiple loci, multilocus association studies (MLAS) are expected to be more powerful than single locus association studies (SLAS) in disease genes mapping. However, some researchers found that MLAS had similar or reduced power relative to SLAS, which was partly attributed to the increased degrees of freedom (dfs) in MLAS. Based on partial least-squares (PLS) analysis, we develop a MLAS approach, while avoiding large dfs in MLAS. In this approach, genotypes are first decomposed into the PLS components that not only capture majority of the genetic information of multiple loci, but also are relevant for target traits. The extracted PLS components are then regressed on target traits to detect association under multilinear regression. Simulation study based on real data from the HapMap project were used to assess the performance of our PLS-based MLAS as well as other popular multilinear regression-based MLAS approaches under various scenarios, considering genetic effects and linkage disequilibrium structure of candidate genetic regions. Using PLS-based MLAS approach, we conducted a genome-wide MLAS of lean body mass, and compared it with our previous genome-wide SLAS of lean body mass. Simulations and real data analyses results support the improved power of our PLS-based MLAS in disease genes mapping relative to other three MLAS approaches investigated in this study. We aim to provide an effective and powerful MLAS approach, which may help to overcome the limitations of SLAS in disease genes mapping.

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Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development

Cited by 22 publications

References 26 publications

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

The quantification of ADAMTS expression in an animal model of cerebral ischemia using real‐time PCR

Multilocus Association Testing of Quantitative Traits Based on Partial Least-Squares Analysis

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