Mass Spectrometry in Drug Metabolism and Disposition 2011
DOI: 10.1002/9780470929278.ch14
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Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging

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Cited by 2 publications
(7 citation statements)
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“…The specific MALDI matrix used is chosen and optimized for sensitive and specific detection of the analyte in either positive or negative ion mode mass spectrometry and to limit interference from matrix peaks. MS/MS imaging for single-reaction monitoring 22 or multiple-reaction monitoring (MRM), 45 and ion mobility, 46 increase the specificity of detection in the presence of chemical noise and isobaric to near-isobaric peaks from other compounds. An example is shown in Figure 3, where the distribution of sinalbin on Noccaea caerulescens tissue was only accomplished using SRM imaging.…”
Section: Pharmaceuticals and Metabolitesmentioning
confidence: 99%
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“…The specific MALDI matrix used is chosen and optimized for sensitive and specific detection of the analyte in either positive or negative ion mode mass spectrometry and to limit interference from matrix peaks. MS/MS imaging for single-reaction monitoring 22 or multiple-reaction monitoring (MRM), 45 and ion mobility, 46 increase the specificity of detection in the presence of chemical noise and isobaric to near-isobaric peaks from other compounds. An example is shown in Figure 3, where the distribution of sinalbin on Noccaea caerulescens tissue was only accomplished using SRM imaging.…”
Section: Pharmaceuticals and Metabolitesmentioning
confidence: 99%
“…22,45,47 For example, MRM imaging was employed to investigate moxifloxacin dosing in a rabbit model of lung tuberculosis. 45 Levofloxacin was homogeneously sprayed onto the tissue as a reference standard for image normalization.…”
Section: Pharmaceuticals and Metabolitesmentioning
confidence: 99%
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