This paper studies properties of an estimator of mean-variance portfolio weights in a market model with multiple risky assets and a riskless asset. Theoretical formulas for the mean square error are derived in the case when asset excess returns are multivariate normally distributed and serially independent. The sensitivity of the portfolio estimator to errors arising from the estimation of the covariance matrix and the mean vector is quantified. It turns out that the relative contribution of the covariance matrix error depends mainly on the Sharpe ratio of the market portfolio and the sampling frequency of historical data. Theoretical studies are complemented by an investigation of the distribution of portfolio estimator for empirical datasets. An appropriately crafted bootstrapping method is employed to compute the empirical mean square error. Empirical and theoretical estimates are in good agreement, with the empirical values being, in general, higher. (JEL: C13, C52, G11) Keywords: Investment analysis, asset allocation, mean-variance portfolio, estimation error, bootstrapThe mean-variance framework, introduced by Markowitz (1952), opened a new era in asset management. The selection of optimal portfolio was formulated as seeking a balance between the risk, measured by the variance of the portfolio return, and the gain, measured by the expectation of the return. A mean-variance * Corresponding author, tel. +44 113 34 35180, fax. +44 113 34 35090