Distributions of human leukocyte antigen–A, –B, and –DRB1 alleles and haplotypes based on 46,915 Taiwanese donors

The distribution of human leukocyte antigen-A, -B, and -DRB1 alleles and haplotypes based on high-resolution genotyping of 167 families from Jiangsu Province, China

“…Similarly, A*02:07 was more common than A*02:01 in the Taiwanese population [8]. In high resolution, A*11:01 was the most frequent allele in Jiangsu, again consistent with findings from northern and southern Chinese populations [4,6].…”

“…The most frequent DRB1 allele in Jiangsu was DRB1*09:01, as it was in northern Chinese, southern Chinese, and Taiwanese [4,6,8], whereas DRB1*09:01 was not reported in a population from Western Javanese [7]. The DRB1*07:01 allele was the second most frequent allele in Jiangsu with a frequency of 13.24%, again consistent with the northern Chinese allele distribution [4], whereas this allele was rare in southern and southwest Chinese [5,6].…”

“…These data were obtained from previous studies, including northern Han Chinese [4], southwestern Han Chinese (Yunnan FYDH) [5], southern Han Chinese [6], Indonesia [7], and Taiwanese Han [8]. In addition, all allele frequencies for HLA-A, -B, and -DRB1 loci for other populations in China and western Javanese Indonesia were obtained from northern Han Chinese [4], southwestern Han Chinese (Yunnan FYDH) [5], southern Han Chinese [6], western Javanese Indonesia [7], Taiwanese Han [8], Beijing Han [9], and Xizang Monba [10]. Genetic distances among the 8 populations were calculated based on HLA-A, -B, and -DRB1 allele frequencies, and a neighbor-joining tree was constructed using Phylip 3.69 (University of Washington, Washington).…”

Polymorphism and uniqueness of Taiwanese in HLA and beyond

“…This assumption was based on our observation that the sequence of A*11:90 is identical to A*11:01:01 in exons 2 and 3 except the segment of the sequence from nt 487 to nt 497, which is identical to A*80:01. The HLA-A, -B and -DRB1 haplotype in association with A*11:90 may be reasonably deduced as A*11:90-B*40:02-DRB1*11:01 taking into the account that the HLA typing of the cell HC22801 listed on the IMGT ⁄ HLA database (http://www.ebi.ac.uk/ imgt/hla/ethnicity.html [9]) which also carries the allele A*11:90. [8,10].…”

Genetic predictors of Stevens–Johnson syndrome and toxic epidermal necrolysis induced by aromatic antiepileptic drugs among the Chinese Han population

“…In the present study, we further confirmed this: five of the 15 patients positive for HLA-B*15:02 also carried A*11:01 and DRB1*12:02 in the SJS/TEN group, and two out of the four patients positive for HLA-B*15:02 carried A*11:01 and DRB1*12:02 simultaneously in the tolerant control group (see Supplementary Table 1 and 2). The haplotype frequency of A*11:01, B*15:02, and DRB1*12:02 was reported to be 0.57% in the Han population of Northern China and 1.5% in Taiwanese [21,22].…”