This article proposes a fixed-time fuzzy disturbance observer–based adaptive integral sliding-mode spacecraft control scheme with consideration of input uncertainties and unknown nonlinearities. First, for the purpose of satisfying the time-varying output constraints and simplifying the computational process, an error transformation function is employed to convert the constrained spacecraft system into an unconstrained one. Second, to ensure superior transient-state performance, an improved sliding manifold integrated with a nonlinear function is designed. Then, for accurately estimating the external disturbances, a fixed-time fuzzy disturbance observer is proposed. Furthermore, the unknown nonlinearities and the input uncertainties are handled by several adaptive laws. The simulation results are presented to verify the superiority and effectiveness of the proposed fixed-time fuzzy disturbance observer–based adaptive integral sliding-mode control scheme.