Disturbance of neuroendocrine regulation of sexual behavior of male rats with streptozotocin diabetes

Abstract

Sexual behavior is a constituent of the reproductive function of the organism. In sexually mature individuals the synchronization of the level of sexual activity with the reaction of the hypothalamo-hypophyseo-gonadal system to the relevant environmental stimuli is a necessary condition for the preservation of the species. In this context, the study of the neuroendocrine mechanisms shaping a specific level of activity of sexual behavior is an important problem for investigators. The dependence of the level of sexual activity on the integrity of certain CNS structures (first of all, the olfactory bulbs, amygdala, hypothalamus, and hypophysis) has been established. It has been demonstrated that label sex steroids accumulate selectively, and the regulation of the function of the gonads on the negative feedback principle is also accomplished in these regions precisely. In addition to the participation of the sex steroids in the formation of a specific level of sexual activity, an important role has been established at the present time for luliberin (LHRH) producing system and the neurotransmitters. The stability of the functioning of the reproductive system depends on a multiplicity of factors of the internal and external milieu. Serious disturbances in its function are associated with the alteration in carbohydrate homeostasis underlying a disease such as diabetes mellitus. This is manifested in a reduction in the weight of the accessory sex glands, steroidogenic activity and spermatogenesis, in a change in the secretion of gonadotropins, as well as in a diminution of fertility and sexual behavior.(ABSTRACT TRUNCATED AT 250 WORDS)

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

“…In agreement with observations showing dysfunction in reproductive axis associated with diabetes [37][38][39][40][41][42][43][44][45], we here demonstrate that T plasma levels are also significantly decreased in STZ-treated rats. Moreover, our data indicate that diabetes causes alterations in the levels of steroids in sciatic nerves that do not completely reflect the changes observed in plasma.…”

Differences in mouse models of diabetes mellitus in studies of male reproduction

“…, 1978). However, few investigations have been conducted into the consequences of STZ diabetes on spermatogenesis or sperm function (El’tseva et al. , 1993; Ballester et al.…”

Immunolesions of Glucoresponsive Projections to the Arcuate Nucleus Alter Glucoprivic-Induced Alterations in Food Intake, Luteinizing Hormone Secretion, and GALP mRNA, but Not Sex Behavior in Adult Male Rats

“…A reduction in leptin and/or insulin levels has also been shown to result in a reduction in circulating LH levels and in sex behavior [34,35,36,37,38]. Treatment with 2DG elicited a slight, but significant decrease in circulating insulin levels – perhaps in an effort to maintain glucose levels in response to the perceived hypoglycemic conditions.…”