Disturbances in bone remodeling during the progress of hamster periodontitis

Makris, Georgios; Saffar, Jean‐Louis

doi:10.1111/j.1600-0765.1985.tb00453.x

Cited by 16 publications

(16 citation statements)

References 8 publications

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“…Notably, this observation suggests the involvement of mechanical forces (may be osteocyte-mediated) in coupling. Makris and Saffar56 reported concomitant increase in reversal surface and decrease in formation surface, thus suggesting uncoupling, during the progress of hamster periodontitis. Parfitt57 reported that in older people, especially those with osteoporosis, a significant proportion of the eroded surface is covered by flat lining cells.…”

Section: Reversal Surfacesmentioning

confidence: 96%

The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation

2014

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The reversal phase couples bone resorption to bone formation by generating an osteogenic environment at remodeling sites. The coupling mechanism remains poorly understood, despite the identification of a number of ‘coupling' osteogenic molecules. A possible reason is the poor attention for the cells leading to osteogenesis during the reversal phase. This review aims at creating awareness of these cells and their activities in adult cancellous bone. It relates cell events (i) on the bone surface, (ii) in the mesenchymal envelope surrounding the bone marrow and appearing as a canopy above remodeling surfaces and (iii) in the bone marrow itself within a 50-μm distance of this canopy. When bone remodeling is initiated, osteoprogenitors at these three different levels are activated, likely as a result of a rearrangement of cell–cell and cell–matrix interactions. Notably, canopies are brought under the osteogenic influence of capillaries and osteoclasts, whereas bone surface cells become exposed to the eroded matrix and other osteoclast products. In several diverse pathophysiological situations, including osteoporosis, a decreased availability of osteoprogenitors from these local reservoirs coincides with decreased osteoblast recruitment and impaired initiation of bone formation, that is, uncoupling. Overall, this review stresses that coupling does not only depend on molecules able to activate osteogenesis, but that it also demands the presence of osteoprogenitors and ordered cell rearrangements at the remodeling site. It points to protection of local osteoprogenitors as a critical strategy to prevent bone loss.

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Section: Reversal Surfacesmentioning

confidence: 96%

The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation

2014

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“…During periodontitis, bone destruction results from an imbalance between bone formation that is inhibited and bone resorption that is increased [ 31 , 32 ]. P. gingivalis infection had a strong impact on bone metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…P. gingivalis factors promote bone resorption [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. In this study, bone resorption was evaluated along the socket of the third molar; the resorption provoked by P. gingivalis infection added to the physiological osteoclastic resorption related to the physiological tooth drift [37] .…”

Section: Discussionmentioning

confidence: 99%

Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice

Coyac

Detzen

Doucet

et al. 2018

Heliyon

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BackgroundPeriodontitis is a set of chronic inflammatory diseases affecting the supporting structures of the teeth, during which a persistent release of lytic enzymes and inflammatory mediators causes a self-perpetuating vicious cycle of tissue destruction and repair. A matrix-based therapy using a heparan sulfate (HS) analogue called ReGeneraTing Agent (RGTA) replaces destroyed HS by binding to available heparin-binding sites of structural molecules, leading to restoration of tissue homeostasis in several inflammatory tissue injuries, including a hamster periodontitis model.MethodsThe ability of RGTA to restore the periodontium was tested in a model of Porphyromonas gingivalis-infected Balb/cByJ mice. After 12 weeks of disease induction, mice were treated weekly with saline or RGTA (1.5 mg/kg) for 8 weeks. Data were analyzed by histomorphometry.ResultsRGTA treatment restored macroscopic bone loss. This was related to (1) a significant reduction in gingival inflammation assessed by a decrease in infiltrated connective tissue, particularly in cells expressing interleukin 1ß, an inflammatory mediator selected as a marker of inflammation; (2) a normalization of bone resorption parameters, i.e. number, activation and activity of osteoclasts, and number of preosteoclasts; (3) a powerful bone formation reaction. The Sharpey's fibers of the periodontal ligament recovered their alkaline phosphatase coating. This was obtained while P. gingivalis infection was maintained throughout the treatment period.ConclusionsRGTA treatment was able to control the chronic inflammation characteristic of periodontitis and blocked destruction of periodontal structures. It ensured tissue regeneration with recovery of the periodontium's anatomy.

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“…Bone remodeling is severely disturbed during the cyclic progression of periodontitis and formative repair episodes are responsible for vigorous bone deposition at the level of endosteal surfaces leading to "corticalization" of the exposed endosteum subjacent to the inflamed gingival and granulation tissues. Resorption in sitespecific areas may be a dominant feature at any given time of the disease and repair episodes may occur at the periphery of a site during the active phases and endosteally during the quiescent phases of the inflammatory process (Makris and Saffar, 1985).…”

Section: Discussionmentioning

confidence: 99%

Paleopathology in Australopithecus africanus: A suggested case of a 3‐million‐year‐old prepubertal periodontitis

Ripamonti

1988

American J Phys Anthropol

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The fossil remains of a juvenile Australopithecus africanus specimen from Sterkfontein Member 4 temporally confined on faunal grounds to 2.5-3.0 million years before the present (Myr B.P.) show pathological alterations of the periodontal alveolar process consistent with a case of prepubertal periodontitis. This diagnosis is based on macroscopic features of alveolar bone loss distribution, pattern of periodontal bone destruction, migration of the affected deciduous molars, and on stereomicroscopic and scanning electron microscopic evidence of alveolar bone destruction. Differential diagnoses and pathological exclusions are discussed in terms of localized patterns of periodontal bone destruction and presumptive survival rate. The reported case appears to be the first detailed description of a recognized disease in early hominid evolution.

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Disturbances in bone remodeling during the progress of hamster periodontitis

Cited by 16 publications

References 8 publications

The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation

The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation

Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice

Paleopathology in Australopithecus africanus: A suggested case of a 3‐million‐year‐old prepubertal periodontitis

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