Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapyA preliminary report

Alpaslan, Gökhan; Alpaslan, Cansu; Gögen, Hakan; Oğuz, Aynur; Çetiner, Sedat; Karadeniz, Ceyda

doi:10.1016/s1079-2104(99)70215-5

Cited by 67 publications

(76 citation statements)

References 12 publications

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“…Reports on the correlation between caries prevalence and chemotherapy exposure in other studies have been inconsistent. 24,55 It is possible that participants attending our long-term follow-up clinic, particularly those who received cyclophosphamide and/or HPCT, were generally a more carefully monitored group of patients due to their increased risk of developing other conditions. Therefore, this group of patients were more likely to receive appropriate dental education and early intervention, thus minimizing the risk of dental caries.…”

Section: Discussionmentioning

confidence: 99%

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

Hsieh

Hibbert

Shaw

et al. 2010

Cancer

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BACKGROUND:The aim of this study was to examine the effect of antineoplastic therapy on dental development and saliva function in recipients of childhood antineoplastic therapy. METHODS: Patients attending the long-term follow-up clinic at Children's Hospital at Westmead, NSW, Australia, were included if they had received treatment prior to 16 years of age and were in remission for more than 5 years. A dental examination and saliva test were performed for each participant. Holtta's Defect Index (HDI) was used to assess tooth aplasia, microdontia, and root-crown ratio on an orthopantomogram (OPG). Multivariable-adjusted regression analyses were used to estimate the association of patient characteristics and treatment modalities with dental outcomes. RESULTS: One hundred six participants (61% male) were recruited (response rate ¼ 88%). The mean HDI score was 24.7 AE 17.8. A cumulative dose of cyclophosphamide >7500 mg/m 2 increased the HDI score by 13.06 (P ¼ .01). Recipients of cyclophosphamide also had significantly increased odds of exhibiting very low saliva flow (<0.7 mL/min) (odds ratio ¼ 12.43; 95% confidence interval, 2.08-74.35; P ¼ .006). CONCLUSIONS: Children and adolescents who received high doses of cyclophosphamide were at increased risk of dental disturbances. Cyclophosphamide recipients were also at greater risk of exhibiting very low saliva flow. This study applied the HDI to patients receiving all forms of antineoplastic treatment and highlights the dose-dependent relation between cumulative dose of cyclophosphamide and dental disturbances.

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Section: Discussionmentioning

confidence: 99%

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

Hsieh

Hibbert

Shaw

et al. 2010

Cancer

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“…Chemotherapeutic agents can cause enamel and dentin hypoplasia, conical roots, short apices, premature apex formation [6,7,[11][12][13][14][15], anomalous teeth [16], and cysts [12,17], as observed in the present case. Cyclophosphamide is considered to be cytostatic, acting on DNA and inhibiting cell division [7].…”

Section: Discussionmentioning

confidence: 66%

“…Anomalies of dental and facial development may be correlated with cancer treatment due to the lack of specificity of antineoplastic therapies such as chemotherapy and radiotherapy [6,7], which do not differentiate between neoplastic cells and active healthy cells [6,8].…”

Section: Introductionmentioning

confidence: 99%

Cystic Odontoma in Patient with Hodgkin's Lymphoma

Kaminagakura

Costa

Strieder

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Cystic odontoma is a rare entity, which is characterized by the association of a cyst with complex/compound odontoma. The aim of this study was to report the case of a 5-year-old male patient diagnosed previously with Hodgkin's lymphoma and treated successfully with chemotherapy and radiotherapy, who developed a mandibular odontogenic lesion. Physical examination revealed a swelling on the right side of the mandible. Radiographically, a well-defined radiolucent area surrounded by radiopaque material was observed. An incisional biopsy was performed and microscopic analysis showed a cystic lesion consisting of an atrophic epithelium comprising 2-3 cell layers and the absence of inflammation in the cystic capsule. The cyst was decompressed and the lesion was removed after 3 months of follow-up. Microscopic analysis of the surgical specimen showed a cystic hyperplastic epithelium surrounded by an intense chronic inflammatory cell infiltrate, which was in close contact with mineralized tissue resembling dentin and cementum. The final diagnosis was cystic odontoma. Since chemotherapy can affect the growth and development of infant teeth, a relationship between chemotherapy-associated adverse events and cystic odontoma is suggested in the present case.

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“…Alpaslan ve arkadaşlarının 38 kanser tedavisi ile diş-lerde anomali görülme sıklığını araştırdıkları çalışmada, çalışma grubunda yaşları 4 ile 15 arasında değişen 30 Hodgkin ve Non Hodgkin lenfomalı çocuk hasta ile kontrol grubunda 20 sağlıklı çocuk incelenmiştir. Çalışma grubunda kanser terapisi ile mine hipoplazisi ve diş renkleşmesi arasında istatistiksel açıdan anlamlı bir ilişki olduğu bildirilmiştir.…”

Section: Tablo 4 Oral Mukozit Için öNerilen Topikal Ajanlarunclassified

Kemoterapi alan çocuklarda diş hekimliği yaklaşımı

Özmekik¹,

Ulukapi²

2014

Acta Odontol Turc

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ÖZET [Abstract in English is at the end of the manuscript] GİRİŞGünümüzde pediatrik hastalar kanser popülasyonunun önemli bir bölümünü oluşturmaktadır. Her yıl dünyada 160.000'den fazla çocuk kansere yakalanmaktadır. Birçok ülkede kanser kayıtları olmadığından, doğru sayı çok iyi bilinmemektedir. Kanser tanı ve tedavisindeki önemli gelişmelere rağmen gelişmiş ülkelerdeki kanserli çocukların %80'i iyileşirken, gelişmekte olan ülkelerde %50'sinden daha azını kurtarmak mümkün olmaktadır 1 . Ülkemizde ise her yıl 2.500-3.000 kadar çocukluk çağı kanseri beklenmektedir. Çocuklarda kanser erişkinlere kıyasla daha nadir olup, tüm kanserlerin %0.5'i 15 yaşından küçük çocuklarda görülmektedir. Bununla birlikte, tedavi başarısının yüksekliği ve çocukların önündeki beklenen yaşam süresinin uzunluğu, erken ve etkin tedaviyi, en iyi hizmete erişimi, yaşam kalitesini, psikososyal yaklaşımı daha da önemli hale getirmektedir.

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Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapyA preliminary report

Cited by 67 publications

References 12 publications

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

Cystic Odontoma in Patient with Hodgkin's Lymphoma

Kemoterapi alan çocuklarda diş hekimliği yaklaşımı

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