Disturbances in psychological functions of workers occupationally exposed to styrene.

Lindström, Karl; Härkönen, Hannu; Hernberg, Sven

doi:10.5271/sjweh.2811

Cited by 80 publications

(29 citation statements)

References 7 publications

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“…The physiologicC'1 tests also revealed slight cerebral dysfunctions, and among them visuomotor inaccuracy was related to high mandelic acid concentration (10). Since the visual cortex is situated in the occipital region and the EEG abnormalities found were relatively frequent in the posterior regions.…”

Section: Mandelic Acid Concentrationmentioning

confidence: 98%

Neurophysiological findings among workers occupationally exposed to styrene.

Seppäläinen¹,

Härkönen²

1976

Scand J Work Environ Health

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findings among workers occupationally exposed to styrene. Scand. j. work environ. & heaUh 3: (1976) 140-146. Ninety-six male workers oc'cupationally exposed to styrene in 24 plants producing reinforced polyester plastic products were studied neurophysiologically. The mean age of the subjects was 29.6 ± 7.4 years, and the duration of the exposure varied from 6 months to 14 years (mean 5.0 years). Mandelic acid concentration in the urine (mean of five values determined during five consecutive weeks) was used as the measure of exposure. The individual means of the mandelic acid concentrations varied from 7 to 4,715 mg/dm 3 (median 808 mg/dm 3 ). Neurotoxic effects of styrene exposure upon the central nervous system were revealed by abnormalities in the EEG. The overall prevalence of abnormal EEGs was· 24 Ofo (23 out of 96), which is higher than that found among a normal population (p < 0.05). Abnormal EEGs were found in one-third of the subjects with relevant styrene exposure (mandelic acid concentration over 700 mg/dm 3 ), while low-level styrene exposure did not increase the prevalence of normal EEGs above that found in a normal population. Nerve conduction velocity measurements performed on 40 subjects did not reveal any definite relationship between neuropathy and styrene exposure. The EEG examination is useful in the investigation of the neurotoxic effects of styrene. Whenever a possibility exists of excessive styrene exposure or beginning poisoning, the workers should be submitted to an EEG examination.

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Section: Mandelic Acid Concentrationmentioning

confidence: 98%

Neurophysiological findings among workers occupationally exposed to styrene.

Seppäläinen¹,

Härkönen²

1976

Scand J Work Environ Health

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“…Epidemiologic investigations of occupationally exposed workers do, however, clearly indioate that long-term exposure to solvent vapors can cause a decrement in behavioral performance capability (29,33,37,38,39,44,52,53).…”

Section: Psychological Examinationmentioning

confidence: 99%

Exposure to organic solvents. A cross-sectional epidemiologic investigation on occupationally exposed care and industrial spray painters with special reference to the nervous system.

Elofsson¹,

Gamberale²,

Hindmarsh³

et al. 1980

Scand J Work Environ Health

249

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“…In addition, abnormal electrocephalographic recordings (10)(11)(12), a decrease in nerve conduction velocity (SO), a reduction in psychomotor speed (13)(14)(15)(16), auditory problems (17), and a high prevalence of acquired color vision loss (18)(19)(20) have been observed among styrene-exposed workers.…”

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confidence: 99%

Visual dysfunction among styrene exposed workers

Campagna¹,

Mergler²,

Huel³

et al. 1995

Scand J Work Environ Health

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dysfunction among styreneexposed workers. Scand J Work Environ Health 1995;21:382-90. Objectives The present study was undertaken to examine the relation between visual functions and occupational exposure to styrene. Methods A total of 128 workers (85% of the total population), from three glass-reinforced plastics plants in Canada, agreed to participate in the study. Environmental and biological measures were made on the day(s) prior to the assessment of near visual acuity (National Optical Visual Chart), chromatic discrimination (Lanthony D-15 desaturated panel), and near contrast sensitivity (Vistech 6000). The analyses were performed on 81 workers with near visual acuity of at least 1 min of arc at 0.5 m. Results The subjects were relatively young [29 (SD 8) years], with little seniority [5 (SD 4) years]. Styrene exposure for 8 h ranged from 6 to 937 (first quartile 21 mg . m-' , third quartile 303 mg . m-'), depending on the job site. The end-shift concentrations of urinary mandelic acid ranged from nondetectable to 1.90 mmol . mmol creatinine-l. Significant positive relations were found between the internal and external styrene exposure measurements and color vision loss adjusted for age, alcohol consumption, and seniority in a multiple regression analysis. The multiple regression analysis also showed that the end-shift concentration of urinary mandelic acid was inversely related to contrast sensitivity at 6 and 12 cycles . degree-'. Logistic multiple regression models indicated that the end-shift concentration of urinary mandelic acid was related to the prevalences of blurred vision, tearing, and eye irritation. C O~C~U S~O~S These findings suggest that there is a positive relation between styrene exposure and early color and contrast vision dysfunction.

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Disturbances in psychological functions of workers occupationally exposed to styrene.

Cited by 80 publications

References 7 publications

Neurophysiological findings among workers occupationally exposed to styrene.

Neurophysiological findings among workers occupationally exposed to styrene.

Exposure to organic solvents. A cross-sectional epidemiologic investigation on occupationally exposed care and industrial spray painters with special reference to the nervous system.

Visual dysfunction among styrene exposed workers

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