Disturbances in Regulation of Catecholamine Neuromediation in Alcoholism

Anokhina, I. P.; Kogan, Boris; Drozdov, A. Z.

doi:10.1093/oxfordjournals.alcalc.a044827

Cited by 9 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute alcohol satisfies the alcohol need, and establishes the temporal balance in the catecholamine turnover [111,112] and results, as is evident from the present and our earlier data [45], in the involvement of additional SE-neurons in the subserving of behavior. In the analysis of cingulate cortex data, we used a log-linear analysis to discover the source of additional SE-neurons.…”

Section: The Effect Of Acute Ethanol Treatment On the Involvement Of supporting

confidence: 67%

The Effect of Ethanol on the Neuronal Subserving of Behavior in the Hippocampus

Alexandrov¹,

Grinchenko²,

Shevchenko³

et al. 2013

JBBS

View full text Add to dashboard Cite

We have previously shown that both acute and chronic ethanol treatment depresses neural activity, specifically in the cingulate cortex. Minor influences were found in the motor cortex. The acute effect of ethanol in the hippocampus was intermediate to those in the cingulate and motor cortices. In the present study, we concentrate on the chronic effects of ethanol on the hippocampus. We demonstrate how the neuronal activity underlying food-acquisition behavior is modified after chronic ethanol treatment, and how the hippocampus subserves formation of newly-formed alcohol-acquisition behavior. Neuronal activity in CA1 was more sensitive to chronic ethanol than the Dg area. Acute administration of ethanol had a normalizing effect on the chronically-treated animals: their performance and the hippocampal neural activity approached a normal range. The sets of neurons involved in food-acquisition behavior formed before chronic ethanol treatment, and those involved in alcohol-acquisition behavior formed after treatment significantly overlapped supporting the view that the neuronal mechanisms of pre-existing behavior provide the basis for the formation of new behavior. Additionally, we also discovered alcohol-acquisition selective neurons. Assuming that the formation of new neuronal specializations underlies learning, we believe that alcohol-selective neurons are specialized during the formation of alcohol-acquisition behavior. Our data demonstrate several new findings on the effect of acute and chronic ethanol on hippocampus activity, and how the neuronal activity relates to behavior before and after ethanol treatment.

show abstract

Section: The Effect Of Acute Ethanol Treatment On the Involvement Of supporting

confidence: 67%

The Effect of Ethanol on the Neuronal Subserving of Behavior in the Hippocampus

Alexandrov¹,

Grinchenko²,

Shevchenko³

et al. 2013

JBBS

View full text Add to dashboard Cite

show abstract

“…If the episodes of acute AI are frequent, pathological changes occur in the neurotransmitter systems: the release of norepinephrine into the bloodstream and its degradation cause a compensatory increase in its synthesis [2,3]. Clearance of excessive norepinephrine is stimulated by increased consumption of alcohol.…”

mentioning

confidence: 99%

“…We think that high blood concentration of acetaldehyde indicates the transition from stage II to stage III: Acetaldehyde produces a specific effect on the synaptic membranes in the brain, which causes an increase in the CNS tolerance to alcohol [3,22,31,33]. This is the last stage of alcoholic disease characterized by mental and.physical dependence on alcohol.…”

mentioning

confidence: 99%

Pathogenesis and morphogenesis of alcoholic disease

1996

Bull Exp Biol Med

View full text Add to dashboard Cite

Experimental, autopsy, and clinical findings call for a new clinical entity, namely, alcoholic disease. The disease has three stages: I) repetitive acute alcohol intoxications; II) drunkenness; and III) alcoholism and alcoholism-related complications. The organs determining the pathogenesis and outcome of alcoholic disease are the liver, heart, lungs, and brain. In chronic alcohol intoxication, lesions in these organs develop in a cascade manner according to the principle of a vicious circle. Pathological changes in the internal organs arise against the background of progressive microangiopathy that by itself is an important pathogenic component of the disease. The results obtained show that changes developing in the internal organs during the second stage are reversible or well compensated, whereas those occurring at the third stage are irreversible in a vast majority of cases and often fatal. There are reasons to consider the problem out of the context of the fight against alcoholism, which, in principle, is an irreversible pathological condition, but from the viewpoint of the proposed concept of alcoholic disease.Alcoholism and alcohol-related complications continue to cause increasing concern all over the world, since they pose a high risk of adverse and irreversible changes in human genome and lead to a great number of medical and social problems [14]. In Russia, a governmental system to combat alcoholism has been established. It includes a network of narcological clinics, dispensaries, narcological centers, etc. The preventive measures and treatment of alcoholism are based on guidelines and recommendations developed by psychiatrists and/or narcologists and are implemented under their supervision. The efficacy of these measures is very low: at the global level, the rates of radical cure of alcoholism range from 3% to 8%, these figures refer to men [4,10]. It should be stressed that the term "cure" is understood as it is interpreted by psychiatrists and narcologists who regard suppression of the desire to drink as the top priority.

show abstract

Biological and genetic markers of alcoholism — a psychiatric perspective

Koller¹,

Soyka²

2001

New and Upcoming Markers of Alcohol Consumption

View full text Add to dashboard Cite

Disturbances in Regulation of Catecholamine Neuromediation in Alcoholism

Cited by 9 publications

References 0 publications

The Effect of Ethanol on the Neuronal Subserving of Behavior in the Hippocampus

The Effect of Ethanol on the Neuronal Subserving of Behavior in the Hippocampus

Pathogenesis and morphogenesis of alcoholic disease

Biological and genetic markers of alcoholism — a psychiatric perspective

Contact Info

Product

Resources

About