Disturbances of Hormonal Circadian Rhythms in Shift Workers

Boivin, Diane B.

doi:10.1007/0-387-23692-9_17

Cited by 6 publications

(8 citation statements)

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“…Circadian rhythms (i.e., endogenously generated biological rhythms of about 24 hours) are observable in many aspects of human physiology and behavior, including neuroendocrine secretion [14], sleep propensity and architecture [10], and subjective and EEG-based estimates of alertness [15]. The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the master circadian pacemaker [16] and coordinates endogenous physiology with the external light-dark environment [17].…”

Section: Hormones and The Sleep-wake And Circadian Cyclesmentioning

confidence: 99%

“…At certain times of day, for example, just before habitual bedtime when the homeostatic drive for sleep is at its peak, and conversely at the end of the sleep episode when it is at its lowest, a strong circadian drive for wakefulness and sleepiness, respectively, counteracts process S. This interaction, referred to as the “opponent process,” results in uninterrupted 8-hour nocturnal sleep and 16-hour waking episodes each day ( Figure 1 ) [ 8 , 13 ]. Circadian rhythms (i.e., endogenously generated biological rhythms of about 24 hours) are observable in many aspects of human physiology and behavior, including neuroendocrine secretion [ 14 ], sleep propensity and architecture [ 10 ], and subjective and EEG-based estimates of alertness [ 15 ]. The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the master circadian pacemaker [ 16 ] and coordinates endogenous physiology with the external light-dark environment [ 17 ].…”

Section: Hormones and The Sleep-wake And Circadian Cyclesmentioning

confidence: 99%

“…A variety of hormones cycle with a 24-hour rhythmicity, though some are more regulated by the endogenously generated circadian system, whereas others are more sensitive to the timing of sleep per se [ 14 ].…”

Section: Hormones and The Sleep-wake And Circadian Cyclesmentioning

confidence: 99%

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Sleep, Hormones, and Circadian Rhythms throughout the Menstrual Cycle in Healthy Women and Women with Premenstrual Dysphoric Disorder

Shechter

Boivin

2010

International Journal of Endocrinology

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131

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A relationship exists between the sleep-wake cycle and hormone secretion, which, in women, is further modulated by the menstrual cycle. This interaction can influence sleep across the menstrual cycle in healthy women and in women with premenstrual dysphoric disorder (PMDD), who experience specific alterations of circadian rhythms during their symptomatic luteal phase along with sleep disturbances during this time. This review will address the variation of sleep at different menstrual phases in healthy and PMDD women, as well as changes in circadian rhythms, with an emphasis on their relationship with female sex hormones. It will conclude with a brief discussion on nonpharmacological treatments of PMDD which use chronotherapeutic methods to realign circadian rhythms as a means of improving sleep and mood in these women.

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Section: Hormones and The Sleep-wake And Circadian Cyclesmentioning

confidence: 99%

Section: Hormones and The Sleep-wake And Circadian Cyclesmentioning

confidence: 99%

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Sleep, Hormones, and Circadian Rhythms throughout the Menstrual Cycle in Healthy Women and Women with Premenstrual Dysphoric Disorder

Shechter

Boivin

2010

International Journal of Endocrinology

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131

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“…Permanent night shift workers exhibit altered melatonin production and sleep patterns [182]. However, a number of studies indicate that many shift-workers retain the typical circadian pattern of melatonin production [183].…”

Section: Implications Of Melatonin's Chronobiotic Actions In Crsdmentioning

confidence: 99%

Melatonin

et al. 2006

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Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light/dark cycle via the suprachiasmatic nucleus. Pinealocytes function as ‘neuroendocrine transducers’ to secrete melatonin during the dark phase of the light/dark cycle and, consequently, melatonin is often called the ‘hormone of darkness’. Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities. Melatonin is exclusively involved in signaling the ‘time of day’ and ‘time of year’ (hence considered to help both clock and calendar functions) to all tissues and is thus considered to be the body's chronological pacemaker or ‘Zeitgeber’. Synthesis of melatonin also occurs in other areas of the body, including the retina, the gastrointestinal tract, skin, bone marrow and in lymphocytes, from which it may influence other physiological functions through paracrine signaling. Melatonin has also been extracted from the seeds and leaves of a number of plants and its concentration in some of this material is several orders of magnitude higher than its night‐time plasma value in humans. Melatonin participates in diverse physiological functions. In addition to its timekeeping functions, melatonin is an effective antioxidant which scavenges free radicals and up‐regulates several antioxidant enzymes. It also has a strong antiapoptotic signaling function, an effect which it exerts even during ischemia. Melatonin's cytoprotective properties have practical implications in the treatment of neurodegenerative diseases. Melatonin also has immune‐enhancing and oncostatic properties. Its ‘chronobiotic’ properties have been shown to have value in treating various circadian rhythm sleep disorders, such as jet lag or shift‐work sleep disorder. Melatonin acting as an ‘internal sleep facilitator’ promotes sleep, and melatonin's sleep‐facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients. A recently introduced melatonin analog, agomelatine, is also efficient for the treatment of major depressive disorder and bipolar affective disorder. Melatonin's role as a ‘photoperiodic molecule’ in seasonal reproduction has been established in photoperiodic species, although its regulatory influence in humans remains under investigation. Taken together, this evidence implicates melatonin in a broad range of effects with a significant regulatory influence over many of the body's physiological functions.

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“…Najważniejszym sygnałem synchronizującym działanie zegara jest światło (1)(2)(3)(4)(5). Praca w nocy i związana z nią ekspozycja na sztuczne światło powoduje hamowanie syntezy i wydzielania melatoniny w nocy i pozostaje w sprzeczności z rytmem okołodobowym (4,6). Uważa się, że zaburzenie rytmu okołodobowego, syntezy melatoniny wraz z niedoborami snu towarzyszące pracy w nocy mogą uczestniczyć w etiologii chorób przewlekłych (7).…”

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Night Work and Health of Nurses and Midviwes - A Review

Burdelak¹,

Pepłońska²

2013

Med Pr

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StreszczeniePraca w nocy prawdopodobnie odgrywa rolę w etiologii chorób przewlekłych poprzez zaburzenie rytmu okołodobowego, obniżenie syntezy melatoniny i niedobory snu. Celem naszej pracy był przegląd badań epidemiologicznych dotyczących związku między pracą w nocy a występowaniem wybranych patologii u pielęgniarek i położnych. Przeglądu dokonano na podstawie publikacji zawartych w bazie Medline, opublikowanych do czerwca 2012 r. Podstawę przeglądu stanowiły artykuły naukowe opisujące wyniki badań przekrojowych (prawie 2/3 wszystkich prac) oraz badań kohortowych (prospektywnych). Zidentyfikowałyśmy ogółem 26 prac oryginalnych, w tym 5 badań epidemiologicznych dotyczących chorób/zaburzeń czynnościowych układu pokarmowego, 3 -zespołu metabolicznego, 2 -cukrzycy typu 2, 9 -chorób układu krążenia i czynników ryzyka chorób układu krążenia, 5 -otyłości/nadwagi, 2 -zaburzeń miesiączkowania i 3 -zaburzeń przebiegu ciąży. Z przeprowadzonej analizy piśmiennictwa wynika, że praca pielęgnia-rek i położnych na zmianach nocnych, w systemie rotacyjnym, najsilniej łączy się ze wzrostem ryzyka otyłości i nadwagi. W każdym z przeanalizowanych przez nas 5 badań dotyczących tego zagadnienia obserwowano omawianą zależność (potwierdzoną istotnością statystyczną wyników), także po uwzględnieniu czynników zakłócających. Sugestywne są także wyniki dotyczące cukrzycy typu 2 i zaburzeń cyklu menstruacyjnego. Dane epidemiologiczne dotyczące pozostałych, omawianych w pracy zaburzeń lub patologii wydają się mniej pewne -podawane wyniki są niespójne lub liczba danych jest zbyt mała, aby można było formułować zdecydowane wnioski. Wskazane jest prowadzenie dalszych badań epidemiologicznych pielęgniarek i położnych pracujących w nocy, w szczególności obserwacji prospektywnych, które pozwolą ustalić, czy potencjalny związek pracy w nocy z omówionymi problemami zdrowotnymi ma charakter przyczynowo-skutkowy. Med. Pr. 2013;64(3):397-418 Słowa kluczowe: pielęgniarki, położne, praca w nocy, zdrowie, choroba AbstractNight shift work has been thought to play a role in the etiology of chronic diseases through a disruption of the circadian rhythm, decreased synthesis of melatonin and sleep deprivation. Our aim was to review the epidemiological studies on the association between night shift work and some pathologies in nurses and midwives. We reviewed publications available in the MEDLINE database and published before June 2012, describing the cross-sectional (almost two thirds of all papers) and cohort studies. In total, we identified 26 original papers, including 5 epidemiological studies addressing diseases or disorders of the digestive system, 3 -metabolic syndrome, 2 -type 2 diabetes, 9 -cardiovascular diseases and CVD risk factors, 5 -obesity/overweight, 2 -menstrual disorders and 3 -poor pregnancy outcomes. The analysis of the literature indicates that night shift work of nurses and midwives is most strongly associated with a higher risk of obesity/overweight. In each of the five studies, which we identified this association was observed (confirme...

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Disturbances of Hormonal Circadian Rhythms in Shift Workers

Cited by 6 publications

References 121 publications

Sleep, Hormones, and Circadian Rhythms throughout the Menstrual Cycle in Healthy Women and Women with Premenstrual Dysphoric Disorder

Sleep, Hormones, and Circadian Rhythms throughout the Menstrual Cycle in Healthy Women and Women with Premenstrual Dysphoric Disorder

Melatonin

Night Work and Health of Nurses and Midviwes - A Review

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