Disturbances of the coagulatory system in patients with severe cerebral trauma. I

Auer, L. M.

doi:10.1007/bf01809225

Cited by 44 publications

(11 citation statements)

References 20 publications

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“…Some degree of coagulopathy has been reported in 15 to 35% of all TBIs 11,18,35 and in more than 60% of patients with severe TBI. 3,7,15 It has been estimated that 15 to 40% of patients with severe TBI have full-blown DIC. 6,15,26,35 These changes in blood coagulation probably reflect the cerebral IC process; studying them may allow us to assess the degree of IC and to monitor its treatment.…”

Section: Discussionmentioning

confidence: 99%

Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury

Stein

Chen²,

Sinson³

et al. 2002

Journal of Neurosurgery

158

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Section: Discussionmentioning

confidence: 99%

Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury

Stein

Chen²,

Sinson³

et al. 2002

Journal of Neurosurgery

158

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“…who also reported the prolongation of TT following head injury;[19] although, Auer L in his study on thirty patients did not find any significant changes in thrombin time. [20]…”

Section: Discussionmentioning

confidence: 99%

“…These findings support the results of Kumara et al . [24] and other,[2023] who have reported that coagulopathy is predictor for poor outcome.…”

Section: Discussionmentioning

confidence: 99%

Coagulopathy as prognostic marker in acute traumatic brain injury

Chhabra

Sharma

Subramanian

et al. 2013

J Emerg Trauma Shock

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Context:Coagulopathy frequently occurs following traumatic brain injury (TBI) and usually occurs 6-72 hour post-trauma. The incidence and the probable risk factors for development of coagulopathy and poor outcome following TBI are largely unknown and vary considerably.Aims:To assess the incidence and probable risk factors for development of coagulopathy and to identify the risk factors for poor outcome in terms of median survival time following TBI.Materials and Methods:In this prospective study over two years, patients of isolated moderate and severe traumatic brain injury (GCS≤12) admitted to trauma center had coagulation profile (PT, APTT, thrombin time, fibrinogen and D-dimer), arterial lactate and ABG analysis done on day of admission and on day three. Coagulopathy was defined as prothrombin time (PT) or/and activated partial thromboplastin time (APTT) more than 1.5 times the normal control. Incidence of in-hospital mortality was assessed in all cases.Statistical Analysis:A stepwise logistic regression analysis was performed to identify risk factors for coagulopathy and mortality in these patients.Results:A total of 208 patients were enrolled in the study. The mean age was 32 ± 12 years and mean GCS was 7.1 ± 2.8. Coagulopathy was present in 46% (n = 96) of patients. Risk factors for development of coagulopathy were found out to be severity of head injury (OR: 2.81), elevated D-dimer (OR: 3.43), low hemoglobin (OR: 3.13), and effaced cisterns in the CT scan (OR: 2.72). Presence of coagulopathy (OR: 2.97) and severity of head injury (OR: 5.70) strongly predicted poor outcome, and were associated with a decreased median survival time.Conclusions:There is a high incidence of coagulopathy following TBI. The presence of coagulopathy as well as of severity of TBI are strong predictors of in-hospital mortality in these patients.

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“…Patients were then that occur in some patients with isolated head trauma. [11][12][13][14][15][16][17][18][19][20][21][22] transferred to the intensive care unit and from there to the Decreased levels of antithrombin (AT), fibrinogen and protein C neurosurgery ward.…”

Section: Discussionmentioning

confidence: 99%